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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-NOV-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_RS01285 [old locus tag: SPP_0258 ]
  • pan locus tag?: PNEUPAN000958000
  • symbol: SPP_RS01285
  • pan gene symbol?: udk_1
  • synonym:
  • product: uridine kinase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_RS01285 [old locus tag: SPP_0258 ]
  • symbol: SPP_RS01285
  • product: uridine kinase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 221112..221729
  • length: 618
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAGAAAAAAGGCTTAGTAGACCAACTAGTCTCAGAGATCGAGACGGGGAAAGTCAGG
    ACACTGGGAATATACGGTCATGGAGCTTCAGGTAAATCAACCTTTGCACAGGAATTGTCC
    CAAGCTTTAGATTCTACTACAGTAAATTTGCTAGAAACAGATCCCTATATCACCTCCGGA
    CGCTATTTGGTAGTACCCAAGGACGCGCCGAATCAAAAGGTGACAGCCAGTCTGCCAGTG
    GCGTATGAACTGGAGAGTTTGCAGAGAGATATCTTTGCCTTGCAGGCGGGTATGGATGTC
    TTGACAATTGAAGAACCTTGGAAGGCTAGTGAAGTCTTGTCTGGAGCCAAACCAATTTTG
    ATTGTCGAAGGGATGTCTGTTGGTTTTCTACCCAAGGAACTCTTTGAAAAAACCATCTGT
    TTCTACACGGATGAGGAGACCGAATTAAAGCGACGCCTTGCTAGAGATACGACTGTGAGA
    AATCGCGATGCATCCTTTATATTGGCTAGCCATCAGATGAGACGGGAGCAGTATCTGCGA
    TACTATAAAGAAACTGAGTCTAAGGCGGATATCTTAGTGGACCAATCAGAAGATAAATTT
    GATGTCAAGAGGACTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    618

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_RS01285 [old locus tag: SPP_0258 ]
  • symbol: SPP_RS01285
  • description: uridine kinase family protein
  • length: 205
  • theoretical pI: 5.18851
  • theoretical MW: 23146.2
  • GRAVY: -0.392195

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.1.48?  ExPASy
    Uridine kinase ATP + uridine = ADP + UMP
  • ⊞TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 45.3)
    and 10 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 13.7)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 13.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair phage/plasmid primase, P4 family, C-terminal domain (TIGR01613; HMM-score: 13.3)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage/plasmid primase, P4 family, C-terminal domain (TIGR01613; HMM-score: 13.3)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogenase iron protein (TIGR01287; EC 1.18.6.1; HMM-score: 12.7)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 11.9)
    arsenical pump-driving ATPase (TIGR04291; EC 3.6.1.-; HMM-score: 11.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 11.3)
    Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 11.3)
    Metabolism Energy metabolism Photosynthesis chlorophyllide reductase iron protein subunit X (TIGR02016; HMM-score: 10.8)
  • TheSEED: see SPP_0258
  • ⊞PFAM:
    P-loop_NTPase (CL0023) PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 45.7)
    and 13 more
    AAA_18; AAA domain (PF13238; HMM-score: 22.6)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 19)
    AAA_33; AAA domain (PF13671; HMM-score: 18.9)
    AAA_17; AAA domain (PF13207; HMM-score: 17.5)
    CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 15.9)
    Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 13.4)
    Fer4_NifH; 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family (PF00142; HMM-score: 13.2)
    no clan defined Sortase; Sortase domain (PF04203; HMM-score: 13.1)
    P-loop_NTPase (CL0023) KTI12; Chromatin associated protein KTI12 (PF08433; HMM-score: 12.8)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 12.7)
    MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 11.8)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 11.7)
    AB_hydrolase (CL0028) Chlorophyllase; Chlorophyllase (PF07224; HMM-score: 10.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.057639
    • TAT(Tat/SPI): 0.012098
    • LIPO(Sec/SPII): 0.005048
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000726544 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKKGLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELSQALDSTTVNLLETDPYITSGRYLVVPKDAPNQKVTASLPVAYELESLQRDIFALQAGMDVLTIEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRLARDTTVRNRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • data available for D39

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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