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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS08260 [old locus tag: SPH_1701 ]
  • pan locus tag?: PNEUPAN002972000
  • symbol: SPH_RS08260
  • pan gene symbol?: murT
  • synonym:
  • product: Mur ligase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS08260 [old locus tag: SPH_1701 ]
  • symbol: SPH_RS08260
  • product: Mur ligase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1569909..1571252
  • length: 1344
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1569909..1571252) NCBI
  • BioCyc: SPH_RS08260 BioCyc
  • MicrobesOnline: see SPH_1701
  • PneumoBrowse for strain D39V: SPV_1416 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACTTAAAAACTACTTTGGGCCTTCTTGCTGGGCGTTCTTCCCACTTCATTTTAAGC
    CGTCTTGGCCGTGGAAGTACGCTCCCAGGTAAAGTCGCCCTTCAATTTGATAAAGATATT
    TTACAAAACCTAGCTAAGAACTACGAGATTGTCGTTGTCACTGGAACAAATGGAAAAACC
    CTGACAACTGCCCTCACTGTCGGCATTTTAAAAGAGGTCTATGGTCAAGTTCTAACCAAT
    CCAAGCGGTGCCAACATGATTACAGGGATTGCAACAACCTTCCTAACAGCCAAATCTTCT
    AAAACTGGAAAAAATATTGCCGTCCTCGAAATTGACGAAGCCAGTCTATCTCGTATCTGT
    GACTATATCCAGCCTAGTCTTTTTGTCATTACTAATATCTTCCGTGACCAGATGGACCGT
    TTCGGTGAAATCTATACTACCTATAACATGATATTGGATGCCATTCGGAAAGTTCCAACT
    GCTACTGTTCTCCTTAACGGAGACAGTCCACTTTTCTACAAGCCAACTATTCCAAACCCT
    ATAGAGTATTTTGGTTTTGACTTGGAAAAAGGACCAGCCCAACTGGCTCACTACAATACC
    GAAGGGATTCTCTGTCCTGACTGCCAAGGCATCCTCAAATATGAGCATAATACCTATGCA
    AACTTGGGTACCTATATCTGTGAAGGTTGTGGATGTAAACGTCCTGATCTCGACTATCGT
    TTGACAAAACTGGTTGAGTTGACCAACAATCGCTCTCGCTTTGTCATAGACGGCCAAGAA
    TACGGTATCCAAATCGGCGGGCTCTATAATATCTATAACGCCCTAGCTGCTGTGGCCATC
    GCCCGTTTCCTAGGTGCCGATTTGCAACTCATCAAACAGGGATTTGACAAGAGCCGTGCT
    GTCTTTGGACGCCAAGAAACCTTTCATATCGGTGACAAGGAATGTACCCTTGTCTTGATT
    AAAAATCCAGTCGGTGCAACCCAAGCTATCGAAATGATCAAACTAGCACCTTATCCATTT
    AGCCTATCTGTCCTCCTTAATGCCAACTATGCAGATGGAATTGACACTAGCTGGATCTGG
    GATGCAGACTTTGAACAAATCACTGACATGGACATTCCTGAAATCAACGCTGGCGGTGTT
    CGTCATTCTGAAATCGCTCGTCGCCTCCGAGTGACTGGCTATCCAGCTGAGAAAATCACT
    GAAACGAGTAATCTGGAGCAAGTTCTCAAGACCATTGAGAATCAAGACTGCAAGCATGCC
    TATATTCTGGCAACTTATACTGCCATGCTGGAATTTCGTGAACTGCTGGCTAGTCGTCAG
    ATTGTTAGAAAGGAGATGAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1344

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS08260 [old locus tag: SPH_1701 ]
  • symbol: SPH_RS08260
  • description: Mur ligase family protein
  • length: 447
  • theoretical pI: 6.51606
  • theoretical MW: 49672.8
  • GRAVY: -0.0621924

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (TIGR01143; EC 6.3.2.10; HMM-score: 60.5)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate--L-alanine ligase (TIGR01082; EC 6.3.2.8; HMM-score: 59.1)
    and 6 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoylalanine--D-glutamate ligase (TIGR01087; EC 6.3.2.9; HMM-score: 37)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramyl-tripeptide synthetase (TIGR01085; HMM-score: 35.9)
    Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 22.4)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (TIGR01081; HMM-score: 19.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs bacillithiol biosynthesis cysteine-adding enzyme BshC (TIGR03998; HMM-score: 16.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid bifunctional protein FolC (TIGR01499; EC 6.3.2.-; HMM-score: 12.8)
  • TheSEED: see SPH_1701
  • ⊞PFAM:
    no clan defined MurT_C; MurT ligase C-terminal (PF08353; HMM-score: 113.2)
    and 3 more
    P-loop_NTPase (CL0023) Mur_ligase_M; Mur ligase middle domain (PF08245; HMM-score: 55.8)
    HUP (CL0039) BshC; Bacillithiol biosynthesis BshC (PF10079; HMM-score: 12.1)
    Zn_Beta_Ribbon (CL0167) TF_Zn_Ribbon; TFIIB zinc-binding (PF08271; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.039851
    • TAT(Tat/SPI): 0.003953
    • LIPO(Sec/SPII): 0.006386
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNLAKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKTGKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILDAIRKVPTATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNTYANLGTYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALAAVAIARFLGADLQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIKLAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVTGYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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