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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS03885 [old locus tag: MDRSPN_00729 ]
  • pan locus tag?: PNEUPAN002681000
  • symbol: MDRSPN_RS03885
  • pan gene symbol?: ABC-N/P_1
  • synonym:
  • product: ABC transporter ATP-binding protein/permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS03885 [old locus tag: MDRSPN_00729 ]
  • symbol: MDRSPN_RS03885
  • product: ABC transporter ATP-binding protein/permease
  • replicon: chromosome
  • strand: +
  • coordinates: 740176..741924
  • length: 1749
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (740176..741924) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1191 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    ATGAAACGACAAACTGTAAACCAGACGCTCAAACGTTTAGTCGTAGATTTAGCAAACCAT
    CCCTTCCTCCTTTTCCTAGCCTTTCTAGGAACTATTGCCCAAGTTGGCTTATCAATTTAC
    CTACCTATTCTGATTGGGCAGGTCATTGACCAAGTCCTAGTGGCTGGTTCATCACCAGTT
    TTTTGGCAGATTTTTCTCCAGATGCTCTTGGTGGTAATAGGAAATACTCTGGTACAATGG
    GCCAATCCTCTCCTCTATAATCGTCTAATCTTCTCTTATACCAGAGATTTACGAGAGCGA
    ATCATCCATAAACTCCATCGGTTACCGATTGCTTTTGCGGATCGGCAAGGCAATGGAGAG
    ATGGTCAGTCGTGTAACCACGGATATCGAACAGTTGGCAGCTGGCTTGACCATGATTTTT
    AACCAATTTTTCATTGGTGTTTTGATGATTTTGGTTAGTATTCTAGCCATGCTCCAAATT
    CATCTCCTCATGACTCTCTTAGTCTTGCTGTTGACGCCACTGTCCATGGTGATTTCACGC
    TTTATTGCCAAGAGATCCTATCATCTCTTCCAGAAGCAAACAGAGACGAGGGGAATTCAG
    ACTCAGTTGATTGAAGAATCGCTTAGCCAGCAGACTATAATCCAGTCCTTCAATGCTCAA
    ACAGAATTTATCCAAAGATTGCGTGAGGCTCATGACAACTACTCAGGCTATTCTCAGTCA
    GCCATCTTTTATTCTTCAACGGTCAATCCTTCGACTCGCTTTGTAAATGCACTCATTTAT
    GCCCTTTTAGCTGGAGTAGGAGCTTATCGTATCATGATGGGTTCAACCTTGACCGTCGGT
    CGTTTAGTGACTTTTTTGAACTATGTTCAGCAATACACCAAGCCCTTTAACGATATTTCT
    TCAGTGCTAGCTGAGTTGCAAAGTGCTCTGGCTTGCGTAGAGCGTATCTATGGAGTCTTA
    GATAGCCCTGAAGTGGCTGAAACAGGTAAGGAAGTCTTGACCAGTGACCAAGTTAAGGGA
    GCTATTTCCTTTAAACATGTCTCTTTTGGCTACCATCCTGAAAAAATTTTGATTAAGGAC
    TTGTCTATCGATATTCCAGCTGGTAGTAAGGTAGCCATCGTTGGTCCGACAGGTGCTGGA
    AAATCAACTCTTATCAATCTCCTTATGCGTTTTTATCCCATTAGCTCGGGAGATATCTTG
    CTGGATGGGCAATCCATTTATGATTATACACGAGCATCATTGAGACAGCAGTTTGGCATG
    GTGCTTCAAGAAACCTGGCTCACACAAGGGACCATTCATGATAATATTGCCTTTGGCAAT
    CCTGAAGCCAGTCGAGAGCAAGTAATTGCTGCTGCCAAAGCAGCTAATGCAGACTTTTTC
    ATCCAACAGTTGCCACAGGGATACGATACCAAGTTGGAAAATGCTGGAGAATCTCTCTCT
    GTCGGCAAAGCTCAGCTCTTGACCATAGCCCGAGTCTTTCTGGCTATTCCAAAGATTCTT
    ATCTTAGACGAGGCAACTTCTTCCATTGATACACGGACAGAAGTGCTGGTACAGGATGCC
    TTTGTAAAACTCATGAAGGGCCGCACAAGTTTCATCATTGCTCACCGTTTGTCAACCATT
    CAGGATGCGGATTTAATTCTTGTCTTAGTAGATGGTGATATTGTTGAATATGGTAACCAT
    CAAGAACTCATGGATAGAAAGGGTAAGTATTACCAAATGCAAAAAGCTGCGGCTTTTAGT
    TCTGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1749

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS03885 [old locus tag: MDRSPN_00729 ]
  • symbol: MDRSPN_RS03885
  • description: ABC transporter ATP-binding protein/permease
  • length: 582
  • theoretical pI: 7.85319
  • theoretical MW: 64887
  • GRAVY: 0.247079

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 391.4)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 391.4)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 376.7)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 351.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 330.9)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 313.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 313.5)
    and 71 more
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 299)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 299)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 283.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 283.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 281.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 260.8)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 260.8)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 260.8)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 258)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 217.2)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 207.9)
    Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 188.2)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 115.4)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 114.2)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 103.4)
    Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 98.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 91.4)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 89.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 88.6)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 82.3)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 80.4)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 80.4)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 77.9)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 74.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 74.1)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 73.3)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 72.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 72)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 72)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 71.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 69.7)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 69.7)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 69.5)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 68.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 67.7)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 66)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 65.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 65)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 63.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 63.2)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 61.3)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 60.6)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 60.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 58.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 58.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 58)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 55.4)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 55.2)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 55.2)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 53.8)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 53.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 52.7)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 51)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 49.4)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 49.4)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 46.5)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 43.5)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 43.1)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 42.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 41.7)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 40.1)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 32.5)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 30)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 21)
    Genetic information processing Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 16.5)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 15.2)
    type IV secretion/conjugal transfer ATPase, VirB4 family (TIGR00929; HMM-score: 14.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA modification GTPase TrmE (TIGR00450; EC 3.6.-.-; HMM-score: 14.5)
    Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 13.7)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 13.2)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 12.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 146.4)
    and 18 more
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 106.1)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 23.5)
    AAA_22; AAA domain (PF13401; HMM-score: 20.3)
    AAA_23; AAA domain (PF13476; HMM-score: 19.1)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 18.1)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 18.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 17.4)
    DUF87; Helicase HerA, central domain (PF01935; HMM-score: 15.3)
    ABC_ATPase; ATPase of the ABC class (PF09818; HMM-score: 15.2)
    DO-GTPase2; Double-GTPase 2 (PF19993; HMM-score: 14.4)
    AAA_18; AAA domain (PF13238; HMM-score: 14)
    Dynamin_N; Dynamin family (PF00350; HMM-score: 13.9)
    AAA_25; AAA domain (PF13481; HMM-score: 13.5)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 13.2)
    no clan defined DUF3683; Protein of unknown function (DUF3683) (PF12447; HMM-score: 12.9)
    P-loop_NTPase (CL0023) AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 12.6)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 11.6)
    ABC_membrane (CL0241) ABC_membrane_3; ABC transporter transmembrane region (PF13748; HMM-score: 10.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.014328
    • TAT(Tat/SPI): 0.000262
    • LIPO(Sec/SPII): 0.008043
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_120164198 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKRQTVNQTLKRLVVDLANHPFLLFLAFLGTIAQVGLSIYLPILIGQVIDQVLVAGSSPVFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRDLRERIIHKLHRLPIAFADRQGNGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQIHLLMTLLVLLLTPLSMVISRFIAKRSYHLFQKQTETRGIQTQLIEESLSQQTIIQSFNAQTEFIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGSTLTVGRLVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLTSDQVKGAISFKHVSFGYHPEKILIKDLSIDIPAGSKVAIVGPTGAGKSTLINLLMRFYPISSGDILLDGQSIYDYTRASLRQQFGMVLQETWLTQGTIHDNIAFGNPEASREQVIAAAKAANADFFIQQLPQGYDTKLENAGESLSVGKAQLLTIARVFLAIPKILILDEATSSIDTRTEVLVQDAFVKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMDRKGKYYQMQKAAAFSSE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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