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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-OCT-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_00291 [new locus tag: MDRSPN_RS01555 ]
  • pan locus tag?: PNEUPAN001109000
  • symbol: kdgA
  • pan gene symbol?: eda
  • synonym:
  • product: bifunctional 2-keto-4-hydroxyglutarate aldolase/2-keto-3-deoxy-6-phosphogluconate aldolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_00291 [new locus tag: MDRSPN_RS01555 ]
  • symbol: kdgA
  • product: bifunctional 2-keto-4-hydroxyglutarate aldolase/2-keto-3-deoxy-6-phosphogluconate aldolase
  • replicon: chromosome
  • strand: -
  • coordinates: 282507..283136
  • length: 630
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AP018391 (282507..283136) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0289 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGACCAAATCAGATACGATTATTGAACTAAAAAAACAAAAAATTGTCGCTGTTATTCGA
    GGAAATACAAAGGAAGAAGGACTGCAAGCCTCGATTGCTTGTATCAAGGGCGGTATCAAA
    GCTATTGAAATCGCCTATACCAATCAGTATGCAGGGCAAATCATCAAGCAACTTGTAGAC
    TTGTATCAGGACGATCAAAGTGTTTGTATCGGTGCAGGTACTGTGATTGATGCCGTAACT
    GCTAGAGATGCTATTCTAGCCGGAGCAAATTACGTTGTTTCTCCATCTTTCCATGCTGAA
    ACTGCAAAAATGTGCAATCTCTACAGCACACCGTACATTCCAGGCTGTATTACTCTCACA
    GAGATAACGACTGCACTTGAAGCCGGTAGTGAAATCATTAAACTCTTCCCAGGTAGTGCT
    CTCAGTCCAGCATATATCTCTGCAGTCAAGGCACCGATCCCACAAGTTTCCGTAATGGTA
    ACCGGAGGAGTCGGCCTAAACAACATTCCTCAATGGTTCGCTGCTGGTGCAGACGCCGTT
    GGAATTGGTGGCGAACTCAATAAACTCGCTTCCCAAGGCGACTTTGACCGCATCAGCGAG
    ATTGCCCAACAGTATGTTACACTCAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    630

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_00291 [new locus tag: MDRSPN_RS01555 ]
  • symbol: KdgA
  • description: bifunctional 2-keto-4-hydroxyglutarate aldolase/2-keto-3-deoxy-6-phosphogluconate aldolase
  • length: 209
  • theoretical pI: 4.94715
  • theoretical MW: 22024.2
  • GRAVY: 0.236842

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TIGR01182; EC 4.1.2.14,4.1.3.16; HMM-score: 161)
    Metabolism Energy metabolism Entner-Doudoroff 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TIGR01182; EC 4.1.2.14,4.1.3.16; HMM-score: 161)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotate dehydrogenase (fumarate) (TIGR01036; EC 1.3.98.1; HMM-score: 14.8)
    Metabolism Energy metabolism Pentose phosphate pathway ribulose-phosphate 3-epimerase (TIGR01163; EC 5.1.3.1; HMM-score: 13.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine-phosphate diphosphorylase (TIGR00693; EC 2.5.1.3; HMM-score: 13.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate-nucleotide diphosphorylase (carboxylating) (TIGR00078; EC 2.4.2.19; HMM-score: 12.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    TIM_barrel (CL0036) Aldolase; KDPG and KHG aldolase (PF01081; HMM-score: 130.8)
    and 3 more
    QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 16.1)
    Ribul_P_3_epim; Ribulose-phosphate 3 epimerase family (PF00834; HMM-score: 14.8)
    DUF561; Protein of unknown function (DUF561) (PF04481; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.021587
    • TAT(Tat/SPI): 0.000383
    • LIPO(Sec/SPII): 0.004489
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBA58497 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEIAYTNQYAGQIIKQLVDLYQDDQSVCIGAGTVIDAVTARDAILAGANYVVSPSFHAETAKMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSALSPAYISAVKAPIPQVSVMVTGGVGLNNIPQWFAAGADAVGIGGELNKLASQGDFDRISEIAQQYVTLR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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