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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS01085 [old locus tags: SPNOXC01920 SPNOXC_01920 ]
  • pan locus tag?: PNEUPAN000872000
  • symbol: SPNOXC_RS01085
  • pan gene symbol?: dapE
  • synonym:
  • product: M20/M25/M40 family metallo-hydrolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS01085 [old locus tags: SPNOXC01920 SPNOXC_01920 ]
  • symbol: SPNOXC_RS01085
  • product: M20/M25/M40 family metallo-hydrolase
  • replicon: chromosome
  • strand: +
  • coordinates: 188548..189921
  • length: 1374
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (188548..189921) NCBI
  • BioCyc: SPNOXC_RS01085 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0152 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGGTTTTTCCTAGCGAACAAGAACAGATTGAAAAATTTGAAAAGGATCATGTAGCCCAG
    CATTATTTTGAGGTTTTGCGTACCTTGATTTCTAAGAAATCAGTCTTTGCCCAGCAGGTT
    GGACTCAAGGAAGTCGCAAATTATCTGGGTGAGATTTTCAAGCGTGTTGGAGCTGAAGTG
    GAGATTGATGAGAGCTATACAGCGCCCTTTGTCATGGCATATTTCAAGAGTTCGCGTCCA
    GATGCCAAGACCTTGATTTTCTATAACCACTATGACACTGTGCCAGCGGATGGGGATCAG
    GTCTGGACAGAGGATCCTTTTACGCTTTCGGTCCGCAATGGCTTCATGTATGGGCGTGGG
    GTTGATGACGACAAGGGTCATATCACAGCTCGCTTGAGTGCTTTGAGAAAATATATGCAG
    CGCCATGATGATTTACCTGTCAATATCAGCTTTATCATGGAGGGAGCGGAGGAATCGGCT
    TCAACAGACCTAGATAAGTATTTGGAAAAGCATGCAGACAAACTCCGTGGGGCGGATTTG
    TTGGTCTGGGAACAAGGGACCAAAAATGCCTTGGAACAACTGGAAATTTCTGGTGGCAAT
    AAGGGGATTGTGACCTTTGATGCCAAGGTAAAAAGCGCTGATGTGGATATCCACTCGAGT
    TATGGTGGCGTTGTGGAATCAGCTCCTTGGTATCTCCTCCAAGCCTTACAGTCTCTTCGT
    GCTGCGGATGGCCGTATCTTGGTTGAAGGCTTGTACGAAGAAGTACAAGAGCCCAATGAA
    CGAGAAATGGCCTTGCTAGAAACTTATGGTCAACGAAACCCAGAGGAAGTTAGTCGGATT
    TATGGATTGGAGTTGCCTCTCTTACAGGAGGATCGGATGGCCTTTCTAAAACGTTTCTTT
    TTCGAGCCAGCGCTTAATATCGAAGGAATCCAGTCTGGTTATCAAGGTCAGGGTGTTAAG
    ACTATTTTACCTGCAGAAGCCAGTGCCAAGCTAGAGGTTCGTCTGGTTCCGGGCCTAGAA
    CCGCATGATGTTCTGGAAAAAATTCGGAAACAGCTAGACAAAAATGGCTTTGATAAGGTA
    GAATTATACTATACCTTGGGAGAGATGAGCTATCGAAGCGATATGAGCGCACCAGCCATT
    CTCAATGTGATCGAGTTGGCCAAGAAATTCTATCCACAGGGCGTTTCAGTCTTGCCGACG
    ACAGCGGGGACAGGACCTATGCATACGGTCTTTGATGCCCTAGAGGTACCAATGGTTGCA
    TTCGGTCTAGGAAATGCCAATAGCCGAGACCACGGTGGAGATGAAAATGTGCGAATCGCT
    GATTATTACACCCATATCGAATTAGTAGAGGAGCTGATTAGAAGCTATGAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1374

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS01085 [old locus tags: SPNOXC01920 SPNOXC_01920 ]
  • symbol: SPNOXC_RS01085
  • description: M20/M25/M40 family metallo-hydrolase
  • length: 457
  • theoretical pI: 4.62079
  • theoretical MW: 51516.8
  • GRAVY: -0.345077

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase, ArgE/DapE family (TIGR01910; EC 3.4.-.-; HMM-score: 105.4)
    Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01246; EC 3.5.1.18; HMM-score: 89.2)
    and 7 more
    Metabolism Amino acid biosynthesis Glutamate family acetylornithine deacetylase (ArgE) (TIGR01892; EC 3.5.1.16; HMM-score: 76.2)
    putative dipeptidase (TIGR01887; EC 3.4.13.-; HMM-score: 52.5)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides dipeptidase PepV (TIGR01886; EC 3.4.13.-; HMM-score: 47)
    N-acetyl-ornithine/N-acetyl-lysine deacetylase (TIGR01902; HMM-score: 44.1)
    Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01900; EC 3.5.1.18; HMM-score: 41.2)
    N-acyl-L-amino-acid amidohydrolase (TIGR01880; EC 3.5.1.14; HMM-score: 37.1)
    putative selenium metabolism hydrolase (TIGR03526; HMM-score: 24.2)
  • TheSEED: see SPNOXC01920
  • ⊞PFAM:
    Peptidase_MH (CL0035) Peptidase_M20; Peptidase family M20/M25/M40 (PF01546; HMM-score: 112.2)
    and 3 more
    no clan defined M20_dimer; Peptidase dimerisation domain (PF07687; HMM-score: 75.9)
    Peptidase_MH (CL0035) Peptidase_M28; Peptidase family M28 (PF04389; HMM-score: 14.7)
    no clan defined BMC; BMC domain (PF00936; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003073
    • TAT(Tat/SPI): 0.001004
    • LIPO(Sec/SPII): 0.000282
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000231797 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVFPSEQEQIEKFEKDHVAQHYFEVLRTLISKKSVFAQQVGLKEVANYLGEIFKRVGAEVEIDESYTAPFVMAYFKSSRPDAKTLIFYNHYDTVPADGDQVWTEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQRHDDLPVNISFIMEGAEESASTDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNKGIVTFDAKVKSADVDIHSSYGGVVESAPWYLLQALQSLRAADGRILVEGLYEEVQEPNEREMALLETYGQRNPEEVSRIYGLELPLLQEDRMAFLKRFFFEPALNIEGIQSGYQGQGVKTILPAEASAKLEVRLVPGLEPHDVLEKIRKQLDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYPQGVSVLPTTAGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVEELIRSYE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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