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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS02490 [old locus tag: SPAP_0503 ]
  • pan locus tag?: PNEUPAN001386000
  • symbol: glnR
  • pan gene symbol?: glnR
  • synonym:
  • product: transcriptional repressor GlnR

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS02490 [old locus tag: SPAP_0503 ]
  • symbol: glnR
  • product: transcriptional repressor GlnR
  • replicon: chromosome
  • strand: +
  • coordinates: 477032..477388
  • length: 357
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (477032..477388) NCBI
  • BioCyc: SPAP_RS02490 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0447 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGAAGGAAAAAGAATTTCGCCGAAATATGGCTGTTTTTCCTATCGGCAGTGTTATGAAG
    TTGACCGATTTATCGGCGCGTCAGATTCGTTATTATGAAGATCAAGAGTTGATCAAGCCC
    GATCGAAACGAAGGAAATCGTCGCATGTATTCCTTGAATGACATGGATCGTCTGCTTGAA
    ATCAAAGATTATATCTCTGAAGGTTATAATATCGCTGCCATTAAGAAAAAATATGCTGAA
    CGTGAAGCGAAATCCAAGAAAGCGGTTAGTCAGACTGAAGTACGTCGTGCACTTCACAAT
    GAACTCCTCCAACAGGGGCGTTTTGCTTCAGTACAGTCACCTTTTGGTCGCGGTTAG
    60
    120
    180
    240
    300
    357

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS02490 [old locus tag: SPAP_0503 ]
  • symbol: GlnR
  • description: transcriptional repressor GlnR
  • length: 118
  • theoretical pI: 10.2522
  • theoretical MW: 13861.8
  • GRAVY: -0.892373

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Signal transduction Regulatory functions DNA interactions Cu(I)-responsive transcriptional regulator (TIGR02044; HMM-score: 37.6)
    Signal transduction Regulatory functions DNA interactions Cd(II)/Pb(II)-responsive transcriptional regulator (TIGR02047; HMM-score: 33.1)
    and 6 more
    Cellular processes Cellular processes Detoxification Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 29.1)
    Signal transduction Regulatory functions DNA interactions Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 29.1)
    Signal transduction Regulatory functions DNA interactions Zn(II)-responsive transcriptional regulator (TIGR02043; HMM-score: 28.3)
    Cellular processes Cellular processes Detoxification redox-sensitive transcriptional activator SoxR (TIGR01950; HMM-score: 23.3)
    Signal transduction Regulatory functions DNA interactions redox-sensitive transcriptional activator SoxR (TIGR01950; HMM-score: 23.3)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid partitioning protein RepA (TIGR03453; HMM-score: 16)
  • TheSEED: see SPAP_0503
  • ⊞PFAM:
    HTH (CL0123) MerR_1; MerR HTH family regulatory protein (PF13411; HMM-score: 64.7)
    and 2 more
    MerR; MerR family regulatory protein (PF00376; HMM-score: 45.3)
    no clan defined PDGF_N; Platelet-derived growth factor, N terminal region (PF04692; HMM-score: 14.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by GlnR*, TF important in Nitrogen assimilation: in TIGR4

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.020205
    • TAT(Tat/SPI): 0.005869
    • LIPO(Sec/SPII): 0.004051
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000659547 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKEKEFRRNMAVFPIGSVMKLTDLSARQIRYYEDQELIKPDRNEGNRRMYSLNDMDRLLEIKDYISEGYNIAAIKKKYAEREAKSKKAVSQTEVRRALHNELLQQGRFASVQSPFGRG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Tomas G Kloosterman, Wouter T Hendriksen, Jetta J E Bijlsma, Hester J Bootsma, Sacha A F T van Hijum, Jan Kok, Peter W M Hermans, Oscar P Kuipers
Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae.
J Biol Chem: 2006, 281(35);25097-109
[PubMed:16787930] [WorldCat.org] [DOI] (P p)Wouter T Hendriksen, Tomas G Kloosterman, Hester J Bootsma, Silvia Estevão, Ronald de Groot, Oscar P Kuipers, Peter W M Hermans
Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae.
Infect Immun: 2008, 76(3);1230-8
[PubMed:18174343] [WorldCat.org] [DOI] (I p)

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