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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_RS05695 [old locus tag: SPD_1063 ]
  • pan locus tag?: PNEUPAN002467000
  • symbol: SPD_RS05695
  • pan gene symbol?: ahrC
  • synonym:
  • product: arginine repressor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_RS05695 [old locus tag: SPD_1063 ]
  • symbol: SPD_RS05695
  • product: arginine repressor
  • replicon: chromosome
  • strand: -
  • coordinates: 1089207..1089638
  • length: 432
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_008533 (1089207..1089638) NCBI
  • BioCyc: G1G6V-1164 BioCyc
  • MicrobesOnline: see SPD_1063
  • PneumoBrowse for strain D39V: SPV_1063 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAATAAAAAAGAGAGACTTGAAAAAATTAGAAGATTGGTGACAGATTATCAAATCGGC
    ACGCAAGAAGAAATTGTAGAACATTTGAAAGAAGCAGGTATCACTGCCACTCAGGCGACG
    GTATCCCGAGATATCAAAGAGTTAGGTATTGTCAAAATTCCTTTGAGAGACAACACCTAT
    GTCTACGAATTGCCAAAATCAATCGTAAAAAGTCTACAACTGGCTGAAGACAATATCGAA
    TCGGCTGAATTGATGGATAAGATGATCAATCTCCAAGTTATTCCAGGAAATACGGCTTTT
    GTAAAAGCTCAGTTAATCGAGACTTTTGCAGACAAGATTTTTAGCTGTTTGACTGATGAT
    GGCTCGATTTTAGTCATTGCCAGAAGTGGAAGTCTAGCAGAGGAAATCTTTGAACAAGTA
    AAAAATTGGTAG
    60
    120
    180
    240
    300
    360
    420
    432

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_RS05695 [old locus tag: SPD_1063 ]
  • symbol: SPD_RS05695
  • description: arginine repressor
  • length: 143
  • theoretical pI: 4.72097
  • theoretical MW: 16167.5
  • GRAVY: -0.161538

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family arginine repressor (TIGR01529; HMM-score: 92.7)
    Signal transduction Regulatory functions DNA interactions arginine repressor (TIGR01529; HMM-score: 92.7)
    and 1 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (TIGR00612; EC 1.17.7.1; HMM-score: 11.8)
  • TheSEED: see SPD_1063
  • ⊞PFAM:
    HTH (CL0123) Arg_repressor; Arginine repressor, DNA binding domain (PF01316; HMM-score: 82.8)
    and 7 more
    no clan defined Arg_repressor_C; Arginine repressor, C-terminal domain (PF02863; HMM-score: 38.2)
    P-loop_NTPase (CL0023) ABC_ATPase; ATPase of the ABC class (PF09818; HMM-score: 18.4)
    HTH (CL0123) HTH_Tnp_Tc3_2; Transposase (PF01498; HMM-score: 14.8)
    ACT (CL0070) ACT_8; ACT domain pair (PF19571; HMM-score: 14)
    no clan defined Baculo_p24; Baculovirus P24 capsid protein (PF05073; HMM-score: 13.8)
    GT-B (CL0113) DUF354; Protein of unknown function (DUF354) (PF04007; HMM-score: 13.5)
    Glyco_transf_41; Glycosyl transferase family 41 (PF13844; HMM-score: 10.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by AhrC*, TF important in Arginine biosynthesis, Arginine degradation: see SPD_1063

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009148
    • TAT(Tat/SPI): 0.002248
    • LIPO(Sec/SPII): 0.001325
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRDIKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVKAQLIETFADKIFSCLTDDGSILVIARSGSLAEEIFEQVKNW

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Tomas G Kloosterman, Oscar P Kuipers
Regulation of arginine acquisition and virulence gene expression in the human pathogen Streptococcus pneumoniae by transcription regulators ArgR1 and AhrC.
J Biol Chem: 2011, 286(52);44594-605
[PubMed:22084243] [WorldCat.org] [DOI] (I p)

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