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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-FEB-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39V
  • locus tag: SPV_0621 [new locus tag: SPV_RS03340 ]
  • pan locus tag?: PNEUPAN001661000
  • symbol: lctO
  • pan gene symbol?: lctO
  • synonym:
  • product: L-Lactate 2-monooxygenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPV_0621 [new locus tag: SPV_RS03340 ]
  • symbol: lctO
  • product: L-Lactate 2-monooxygenase
  • replicon: chromosome
  • strand: +
  • coordinates: 642953..644089
  • length: 1137
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP027540 (642953..644089) NCBI
  • BioCyc: SPV_0621 BioCyc
  • MicrobesOnline:
  • PneumoBrowse: SPV_0621 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGTCATACAAAACAAGCAATGCAGAAGGCCATGTAGATTTCATCAATACCTATGATTTG
    GAGCCAATGGCGCAACAAGTTATTCCTAAAGCAGCATTTGGCTATATCGCTAGTGGGGCG
    GAAGATACTTTCACTTTAAGAGAGAATATCCGCGCCTTTAACCACAAACTCATCGTTCCT
    CATACACTTTGCGATGTTGAAAATCCAAGTACAGAGATTGAATTTGCAGGTGAAAAACTA
    TCTTCACCAATCATTATGGCGCCTGTTGCGGCCCATAAATTAGCGAATGAACAGGGGGAA
    GTGGCGACTGCGCGTGGTGTGCATGAGTTTGGTTCTCTTTATACAACCAGTTCTTACTCT
    ACTGTTGACCTTCCAGAGATTTCTGAAGCCCTTCAAGGGACACCTCATTGGTTTCAATTT
    TACTTTAGTAAGGATGACGGTATCAACCGCCACATCATGGACCGTGTGAAGGCTGAAGGT
    TATAAAGCGATTGTCTTGACGGCAGATGCTACTGTAGGGGGGAATCGTGAAGTGGATAAG
    CGTAATGGTTTTGTCTTCCCAGTTGGCATGCCGATTGTTGAAGAATACCTGCCAGAAGGT
    GCTGGTAAATCAATGGACTTTGTTTATAAATCAGCTAAACAACGCTTGTCTCCACGCGAT
    GTAGAATTTATCGCTGAATACTCTGGTCTTCCTGTGTATGTCAAGGGACCACAATGCCGT
    GAGGACGTTGAACGTTCGCTTGCTGCAGGAGCTTCTGGTATCTGGGTAACCAACCACGGT
    GGTCGTCAAATCGACGGTGGACCAGCTGCCTTTGACTCGCTTCAAGAAGTGGCAGAAGCA
    GTTGATAGACGTGTGCCGATTGTCTTTGACTCTGGTGTTCGTCGTGGTCAACACGTCTTT
    AAAGCCTTGGCTTCAGGAGCAGACTTGGTAGCTATTGGTCGCCCTGTTATCTATGGCTTG
    GCTCTCGGTGGTAGTGTCGGTGTGCGTCAAGTCTTTGAACACTTGAATGCGGAATTGAAG
    ACAGTTATGCAATTGTCTGGAGCTCAGACCATTGAAGATGTCAAACACTTTAAGCTCCGT
    CACAATCCATACAACCCAACCTTCCCAGTTGACCCTCGTGACTTAAAATTGTATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1137

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPV_0621 [new locus tag: SPV_RS03340 ]
  • symbol: LctO
  • description: L-Lactate 2-monooxygenase
  • length: 378
  • theoretical pI: 5.93644
  • theoretical MW: 41488.6
  • GRAVY: -0.228571

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 1.13.12.4?  ExPASy
    Lactate 2-monooxygenase (S)-lactate + O2 = acetate + CO2 + H2O
  • ⊞TIGRFAM:
    Metabolism Energy metabolism Other L-lactate oxidase (TIGR02708; EC 1.1.3.-; HMM-score: 758.5)
    and 7 more
    heme/flavin dehydrogenase, mycofactocin system (TIGR03966; EC 1.-.-.-; HMM-score: 157.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other isopentenyl-diphosphate delta-isomerase, type 2 (TIGR02151; EC 5.3.3.2; HMM-score: 45.5)
    Unknown function General IMP dehydrogenase family protein (TIGR01304; HMM-score: 18.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 16.8)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 14)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotate dehydrogenase (fumarate) (TIGR01036; EC 1.3.98.1; HMM-score: 11.8)
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 11.4)
  • TheSEED: data available for D39, TIGR4
  • ⊞PFAM:
    TIM_barrel (CL0036) FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 362)
    and 6 more
    IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 25)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 15.5)
    DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 14.9)
    Glu_synthase; Conserved region in glutamate synthase (PF01645; HMM-score: 13.1)
    ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 12.3)
    NMO; Nitronate monooxygenase (PF03060; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006696
    • TAT(Tat/SPI): 0.001887
    • LIPO(Sec/SPII): 0.000831
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AVN85768 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEGYKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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