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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV200
  • locus tag: SPNINV200_RS04310 [old locus tag: SPNINV200_08020 ]
  • pan locus tag?: PNEUPAN002671000
  • symbol: SPNINV200_RS04310
  • pan gene symbol?: iolX_1
  • synonym:
  • product: Gfo/Idh/MocA family oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNINV200_RS04310 [old locus tag: SPNINV200_08020 ]
  • symbol: SPNINV200_RS04310
  • product: Gfo/Idh/MocA family oxidoreductase
  • replicon: chromosome
  • strand: +
  • coordinates: 815325..816434
  • length: 1110
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017593 (815325..816434) NCBI
  • BioCyc: SPNINV200_RS04310 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGGTAAATTACGGTATTGTTGGAGCTGGATATTTTGGAGCTGATTTAGCTCGCTCAATG
    AACAAAATTGAAGATGCAAAAGTGGTTGCGGTATTTGACCCAAATCATGGAGAAGAAGTT
    GCTCAAGAGTTGGGATCAGATGTTTGTGCAAGTTTAGATGAACTTGTAGCACGTGAAGAT
    ATTGATTGTGTGATCGTAGCTTCACCTAGCTACCTTCACCGTGAACCAGTTGTGAAAGCT
    GCTCAACATGGCAAACACGTATTTTGTGAAAAGCCAATTGCATTGTCTTATGAAGATTGT
    AAAGCCATGGTTGACGCATGTAAAGAAAATAATGTTATCTTTATGGCTGGTCACATCATG
    AACTTCTTTAACGGTGTACACCATGCTAAAGAATTGATTACTCAAGGTAAAATCGGTAAA
    GTTCTTTATTGCCATGCCGCTCGTACAGGTTGGGAAGAACAACAACCAACTGTATCATGG
    AAGAAACTTCGTTCTCAATCTGGAGGACATTTGTACCATCATATTCATGAATTAGATTGC
    ATTCAGTTTATCATGGGAGGACTTCCTGAAAAAGCGACAATGGTAGGAGGCAATGTATAT
    CATAAAGGTGAAAACTTTGGTGATGAAGATGATATGCTCATTGTAAACTTAGAATACTCT
    GATGATCGTTATGCTGTTTTGGAATATGGTAATGCTTTCCGTTGGGGTGAACACTACGTC
    TTGATTCAAGGAACTGAAGGAGCTATCAAACTTGATTTGTTCAATACTGGAGGTACTCTT
    CGTGTTAAAGGTGAAGGAGAATCACACTTCTTAGTTCATGAAACTCAAGAGGAAGATGAT
    GACCGTACAGCTATCTATACCGGTCGTGGTATGGATGGAGCAATTGCGTACGGTAAACCA
    GGAGTACGTTGCCCATTATGGTTGCAAACATGTATTGATAAAGAAATGGAATATCTACAT
    GACATCATTAAAGGTGGAGAAATTACAGAAGAATATGAAAAACTTCTCAATGGTGTAGCT
    GCTTTAGAATCAATCGCTACCGCTGATGCATGTACTTTATCAGTTAAAGAAGATCGAAAA
    GTAAGTCTTTCAGAAATCACAAATGCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1110

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNINV200_RS04310 [old locus tag: SPNINV200_08020 ]
  • symbol: SPNINV200_RS04310
  • description: Gfo/Idh/MocA family oxidoreductase
  • length: 369
  • theoretical pI: 4.81321
  • theoretical MW: 40860.9
  • GRAVY: -0.257995

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Energy metabolism Sugars inositol 2-dehydrogenase (TIGR04380; EC 1.1.1.18; HMM-score: 135.5)
    and 4 more
    Metabolism Amino acid biosynthesis Serine family phosphoglycerate dehydrogenase (TIGR01327; EC 1.1.1.95; HMM-score: 19.9)
    acetaldehyde dehydrogenase (acetylating) (TIGR03215; EC 1.2.1.10; HMM-score: 15.3)
    aspartate dehydrogenase (TIGR03855; EC 1.4.1.21; HMM-score: 13.4)
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 11.6)
  • TheSEED: see SPNINV200_08020
  • ⊞PFAM:
    GADPH_aa-bio_dh (CL0139) GFO_IDH_MocA_C; Oxidoreductase family, C-terminal alpha/beta domain (PF02894; HMM-score: 157.1)
    and 7 more
    NADP_Rossmann (CL0063) GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 110.4)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 21.9)
    NAD_binding_3; Homoserine dehydrogenase, NAD binding domain (PF03447; HMM-score: 21.5)
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 21.2)
    CoA_binding; CoA binding domain (PF02629; HMM-score: 17.2)
    DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 14.9)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007633
    • TAT(Tat/SPI): 0.000284
    • LIPO(Sec/SPII): 0.00168
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000248712 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVNYGIVGAGYFGADLARSMNKIEDAKVVAVFDPNHGEEVAQELGSDVCASLDELVAREDIDCVIVASPSYLHREPVVKAAQHGKHVFCEKPIALSYEDCKAMVDACKENNVIFMAGHIMNFFNGVHHAKELITQGKIGKVLYCHAARTGWEEQQPTVSWKKLRSQSGGHLYHHIHELDCIQFIMGGLPEKATMVGGNVYHKGENFGDEDDMLIVNLEYSDDRYAVLEYGNAFRWGEHYVLIQGTEGAIKLDLFNTGGTLRVKGEGESHFLVHETQEEDDDRTAIYTGRGMDGAIAYGKPGVRCPLWLQTCIDKEMEYLHDIIKGGEITEEYEKLLNGVAALESIATADACTLSVKEDRKVSLSEITNA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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