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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS09415 [old locus tag: SPH_1930 ]
  • pan locus tag?: PNEUPAN000193000
  • symbol: SPH_RS09415
  • pan gene symbol?: nagC
  • synonym:
  • product: ROK family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS09415 [old locus tag: SPH_1930 ]
  • symbol: SPH_RS09415
  • product: ROK family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 1793315..1794493
  • length: 1179
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1793315..1794493) NCBI
  • BioCyc: SPH_RS09415 BioCyc
  • MicrobesOnline: see SPH_1930
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGACCTTATCTAAGAAACAATTACAACTACGAGCTAAAATACTGGAAACAGTTTACACA
    TTAGGTCCCATTTCACGAATTGAAATCGCTACTAAAACAGGAATAACACCTGCAACAACT
    AGCAGTATCACAAATGATCTGATTAAAGAAAACATTCTCTTAGAACTTGGTGAAGACGAA
    CACGATACAAGCGTAGGGAGAAAAAAAATCCTGCTAGACATTCAAGCTAAACGATTTTAC
    TACATTGGTTGTGAACTATCTGAAAAACATTTCACTTTTGCTTTAGGAGATAATCTAGGA
    AATATCTTAAAGGAAGAGAAAGAAATTGTTACTAAACAGTTAATCCAAGAAAAGGGAAAT
    CAACTCATTAGCCAGACACTAAAGCAATTCTTAAATAACTGCTCTGATTATGAAATAGAA
    GCAATTGGAATCGCGCTACCTGGTCGCTATTTAGATGATTATAAAATAACAACAAACAAT
    CCTTTATGGCAACATATCGACTTAGAAATGATTCAATCCCACTTTGATAAGCCTTTGTTT
    TTCTCTAACAATGTTAACTGTATGGCTATAGGTAAACGCCTATTTAGTCGCCAACAGAAT
    GACCCTAATTTTGCTTATTTTCATTTTGCTAGAGGTATGCACTGTTCTTATATCTACGAC
    GGAAACATTTATGGAAAAGGAAATCTAATGATTGGAGAAATAGGGCATACAGTTGTTTCA
    TCTGAGGGAGAAGAATGTAGTTGCGGGCGCAAGGGATGCTTACAAACTTTTGCTGGAGAA
    TCTTGGTTAATCAAAAAATCAAAAATTCTATATCATCAATCTCCCTATTCTCTACTTCCT
    AGTTTAGTCAAAAATGCCGATGATATTGATATCCAAGTTATTTTAACCGCTTATCAATTA
    GGTGACACTGGAATAATCACACTTATCCATCAAGCCTTACTCTATCTTAGTCAAACCATT
    TTAAATATCAGTATGATGATTGACTCTCAAAAAATCTACCTACATAGTCCTTTACTAACA
    AATCAACACATCATCCAAAAACTATATAGTGAAATGAACTACAAACCCAAACTGCTCTAT
    AATCGCCTACCTGAAGTCATTATTGAACCTTACAATGATTTTACAGCCGCACACTCAGCT
    ATTGCACTTTGTTTGTATCATACAATTCTACATTCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1179

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS09415 [old locus tag: SPH_1930 ]
  • symbol: SPH_RS09415
  • description: ROK family transcriptional regulator
  • length: 392
  • theoretical pI: 6.87386
  • theoretical MW: 44577.1
  • GRAVY: -0.147194

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General ROK family protein (putative glucokinase) (TIGR00744; HMM-score: 57)
  • TheSEED: see SPH_1930
  • ⊞⊞PFAM:
    Actin_ATPase (CL0108) ROK; ROK family (PF00480; HMM-score: 113.7)
    and 3 more
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 22.8)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 20.7)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 13.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by NagC*, TF important in Cellobiose utilization: see SPH_1930

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02915
    • TAT(Tat/SPI): 0.003311
    • LIPO(Sec/SPII): 0.002724
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTLSKKQLQLRAKILETVYTLGPISRIEIATKTGITPATTSSITNDLIKENILLELGEDEHDTSVGRKKILLDIQAKRFYYIGCELSEKHFTFALGDNLGNILKEEKEIVTKQLIQEKGNQLISQTLKQFLNNCSDYEIEAIGIALPGRYLDDYKITTNNPLWQHIDLEMIQSHFDKPLFFSNNVNCMAIGKRLFSRQQNDPNFAYFHFARGMHCSYIYDGNIYGKGNLMIGEIGHTVVSSEGEECSCGRKGCLQTFAGESWLIKKSKILYHQSPYSLLPSLVKNADDIDIQVILTAYQLGDTGIITLIHQALLYLSQTILNISMMIDSQKIYLHSPLLTNQHIIQKLYSEMNYKPKLLYNRLPEVIIEPYNDFTAAHSAIALCLYHTILHS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPH_RS09415&oldid=10473"
Insert paragraph

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS09415 [old locus tag: SPH_1930 ]
  • pan locus tag?: PNEUPAN000193000
  • symbol: SPH_RS09415
  • pan gene symbol?: nagC
  • synonym:
  • product: ROK family transcriptional regulator

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS09415 [old locus tag: SPH_1930 ]
  • symbol: SPH_RS09415
  • product: ROK family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 1793315..1794493
  • length: 1179
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1793315..1794493) NCBI
  • BioCyc: SPH_RS09415 BioCyc
  • MicrobesOnline: see SPH_1930
  • PneumoBrowse for strain D39V:

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGACCTTATCTAAGAAACAATTACAACTACGAGCTAAAATACTGGAAACAGTTTACACA
    TTAGGTCCCATTTCACGAATTGAAATCGCTACTAAAACAGGAATAACACCTGCAACAACT
    AGCAGTATCACAAATGATCTGATTAAAGAAAACATTCTCTTAGAACTTGGTGAAGACGAA
    CACGATACAAGCGTAGGGAGAAAAAAAATCCTGCTAGACATTCAAGCTAAACGATTTTAC
    TACATTGGTTGTGAACTATCTGAAAAACATTTCACTTTTGCTTTAGGAGATAATCTAGGA
    AATATCTTAAAGGAAGAGAAAGAAATTGTTACTAAACAGTTAATCCAAGAAAAGGGAAAT
    CAACTCATTAGCCAGACACTAAAGCAATTCTTAAATAACTGCTCTGATTATGAAATAGAA
    GCAATTGGAATCGCGCTACCTGGTCGCTATTTAGATGATTATAAAATAACAACAAACAAT
    CCTTTATGGCAACATATCGACTTAGAAATGATTCAATCCCACTTTGATAAGCCTTTGTTT
    TTCTCTAACAATGTTAACTGTATGGCTATAGGTAAACGCCTATTTAGTCGCCAACAGAAT
    GACCCTAATTTTGCTTATTTTCATTTTGCTAGAGGTATGCACTGTTCTTATATCTACGAC
    GGAAACATTTATGGAAAAGGAAATCTAATGATTGGAGAAATAGGGCATACAGTTGTTTCA
    TCTGAGGGAGAAGAATGTAGTTGCGGGCGCAAGGGATGCTTACAAACTTTTGCTGGAGAA
    TCTTGGTTAATCAAAAAATCAAAAATTCTATATCATCAATCTCCCTATTCTCTACTTCCT
    AGTTTAGTCAAAAATGCCGATGATATTGATATCCAAGTTATTTTAACCGCTTATCAATTA
    GGTGACACTGGAATAATCACACTTATCCATCAAGCCTTACTCTATCTTAGTCAAACCATT
    TTAAATATCAGTATGATGATTGACTCTCAAAAAATCTACCTACATAGTCCTTTACTAACA
    AATCAACACATCATCCAAAAACTATATAGTGAAATGAACTACAAACCCAAACTGCTCTAT
    AATCGCCTACCTGAAGTCATTATTGAACCTTACAATGATTTTACAGCCGCACACTCAGCT
    ATTGCACTTTGTTTGTATCATACAATTCTACATTCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1179

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS09415 [old locus tag: SPH_1930 ]
  • symbol: SPH_RS09415
  • description: ROK family transcriptional regulator
  • length: 392
  • theoretical pI: 6.87386
  • theoretical MW: 44577.1
  • GRAVY: -0.147194

Insert paragraph

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General ROK family protein (putative glucokinase) (TIGR00744; HMM-score: 57)
  • TheSEED: see SPH_1930
  • ⊞PFAM:
    Actin_ATPase (CL0108) ROK; ROK family (PF00480; HMM-score: 113.7)
    and 3 more
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 22.8)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 20.7)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 13.9)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by NagC*, TF important in Cellobiose utilization: see SPH_1930

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02915
    • TAT(Tat/SPI): 0.003311
    • LIPO(Sec/SPII): 0.002724
  • predicted transmembrane helices (TMHMM): 0

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MTLSKKQLQLRAKILETVYTLGPISRIEIATKTGITPATTSSITNDLIKENILLELGEDEHDTSVGRKKILLDIQAKRFYYIGCELSEKHFTFALGDNLGNILKEEKEIVTKQLIQEKGNQLISQTLKQFLNNCSDYEIEAIGIALPGRYLDDYKITTNNPLWQHIDLEMIQSHFDKPLFFSNNVNCMAIGKRLFSRQQNDPNFAYFHFARGMHCSYIYDGNIYGKGNLMIGEIGHTVVSSEGEECSCGRKGCLQTFAGESWLIKKSKILYHQSPYSLLPSLVKNADDIDIQVILTAYQLGDTGIITLIHQALLYLSQTILNISMMIDSQKIYLHSPLLTNQHIIQKLYSEMNYKPKLLYNRLPEVIIEPYNDFTAAHSAIALCLYHTILHS

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • regulator:

Insert paragraph

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph