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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS10795 [old locus tags: SPNOXC19500 SPNOXC_19500 ]
  • pan locus tag?: PNEUPAN003910000
  • symbol: SPNOXC_RS10795
  • pan gene symbol?: comFA
  • synonym:
  • product: DEAD/DEAH box helicase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS10795 [old locus tags: SPNOXC19500 SPNOXC_19500 ]
  • symbol: SPNOXC_RS10795
  • product: DEAD/DEAH box helicase
  • replicon: chromosome
  • strand: -
  • coordinates: 2004368..2005666
  • length: 1299
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (2004368..2005666) NCBI
  • BioCyc: SPNOXC_RS10795 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2035 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGAAAGTAAATTTAGATTATCTCGGTCGTTTATTTACTGAGAATGAATTAACAGAAGAA
    GAACGTCAGTTGGCGGAGAAACTTCCAGCAATGAGAAAGGAGAAGGGGAAACTTTTCTGT
    CAACGTTGTAATAGTACTATTCTAGAAGAATGGTATTTGCCCATCGGTGCTTACTATTGT
    CGAGAGTGCTTGCTGATGAAGCGAGTCAGAAGTGATCAAACTTTATACTATTTTCCGCAG
    GAGGATTTTCCGAAGCAAGATGTTCTCAAATGGCGCGGCCAATTAACTCCTTTTCAAGAG
    AAGGTGTCAGAGGGACTGCTTCAAGCAGTAGACAAGCAAAAGCCAACCTTAGTTCATGCG
    GTAACAGGAGCTGGAAAGACAGAAATGATTTATCAAGTAGTGGCTAAAGTGATCAATGCG
    GGTGGTGCAGTGTGTTTGGCTAGTCCTCGCATAGATGTTTGTTTGGAGCTGTACAAGCGC
    CTGCAACAGGATTTTTCTTGCGGGATAGCTTTGCTACATGGAGAATCGGAACCTTATTTT
    CGAACACCACTAGTTGTTGCAACAACCCATCAGTTATTGAAGTTTTATCAAGCTTTTGAT
    TTGCTGATAGTGGATGAAGTAGATGCTTTTCCTTATGTTGATAATCCCACGCTTTACCAC
    GCTGTCAAGAATAGTGTAAAGGAGAATGGATTGAGAATCTTTTTAACAGCGACTTCGACC
    AATGAGTTAGATAAAAAGGTCCGTTTAGGAGAACTAAAAAGACTGAGTTTACCGAGACGG
    TTTCATGGAAATCCGTTGATTATTCCAAAACCAATTTGGTTATCGGATTTTAATCGCTAC
    TTAGACAAGAATCGTTTGTCACCAAAGTTAAAGTCCTATATTGAGAAGCAGAGAAAGACA
    GCTTATCCGTTACTCATTTTTGCTTCAGAAATTAAGAAAGGGGAGCAGTTAGAAGAAATC
    TTACAGGAGCAATTTCCAAATGAGAAAATTGGCTTTGTATCTTCTGTAACAGAGGATCGA
    TTAGAGCAAGTACAAGCTTTTCGAGATGGAGAACTGACAATACTTATCAGTACGACAATC
    TTGGAGCGTGGAGTTACCTTCCCTTGTGTGGATGTTTTCGTAGTAGAGGCCAATCATCGT
    TTGTTTACCAAGTCTAGTTTGATTCAGATTGGTGGACGAGTTGGACGAAGCATGGATAGA
    CCGACAGGAGATTTGCTTTTCTTCCATGATGGGTTAAATGCTTCAATCAAGAAGGCGATT
    AAGGAAATTCAGATGATGAATAAGGAGGCTGGTCTATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1299

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS10795 [old locus tags: SPNOXC19500 SPNOXC_19500 ]
  • symbol: SPNOXC_RS10795
  • description: DEAD/DEAH box helicase
  • length: 432
  • theoretical pI: 8.51349
  • theoretical MW: 49563.1
  • GRAVY: -0.265741

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair primosomal protein N' (TIGR00595; EC 3.6.1.-; HMM-score: 56.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecG (TIGR00643; EC 3.6.4.12; HMM-score: 53.7)
    and 9 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair transcription-repair coupling factor (TIGR00580; EC 3.6.1.-; HMM-score: 40.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 33)
    CRISPR-associated helicase Cas3 (TIGR01587; HMM-score: 25.9)
    DEXH box helicase, DNA ligase-associated (TIGR04121; EC 3.6.4.-; HMM-score: 18.9)
    helicase/secretion neighborhood putative DEAH-box helicase (TIGR03817; HMM-score: 16.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair ATP-dependent DNA helicase RecQ (TIGR01389; EC 3.6.4.12; HMM-score: 16.6)
    CRISPR-associated helicase Cas3, subtype CYANO (TIGR03158; HMM-score: 14.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 12.8)
    Genetic information processing Mobile and extrachromosomal element functions Other conjugative coupling factor TraD, SXT/TOL subfamily (TIGR03743; HMM-score: 10)
  • TheSEED: see SPNOXC19500
  • ⊞PFAM:
    P-loop_NTPase (CL0023) Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 55.5)
    and 11 more
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 31.6)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 27.3)
    AAA_30; AAA domain (PF13604; HMM-score: 20.1)
    AAA_19; AAA domain (PF13245; HMM-score: 14.9)
    UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 14.7)
    NADP_Rossmann (CL0063) Glyco_tran_WecG; Glycosyl transferase WecG/TagA/CpsF family (PF03808; HMM-score: 14.1)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 14)
    Bac_DnaA; Bacterial dnaA protein (PF00308; HMM-score: 13.9)
    Viral_helicase1; Viral (Superfamily 1) RNA helicase (PF01443; HMM-score: 13)
    AAA_14; AAA domain (PF13173; HMM-score: 12.6)
    Zn_Beta_Ribbon (CL0167) zf-RRN7; Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 (PF11781; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.023998
    • TAT(Tat/SPI): 0.000922
    • LIPO(Sec/SPII): 0.002656
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000867612 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCNSTILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKVSEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKRLQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPTLYHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLSLPRRFHGNPLIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLEEILQEQFPNEKIGFVSSVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGGRVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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