⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 31-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae TIGR4
locus tag: SP_1191 [new locus tag: SP_RS05855 ]
pan locus tag^?: PNEUPAN002456000
symbol: lacC
pan gene symbol^?: lacC
• synonym:
• product: tagatose-6-phosphate kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP_1191 [new locus tag: SP_RS05855 ]
• symbol: lacC
• product: tagatose-6-phosphate kinase
• replicon: chromosome
• strand: -
• coordinates: 1127919..1128848
• length: 930
• essential: unknown

⊟Accession numbers

• Location: AE005672 (1127919..1128848) NCBI
• BioCyc: see SP_RS05855
• MicrobesOnline: 116659 MicrobesOnline
• PneumoBrowse for strain D39V: SPV_1051 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGATTTTAACAGTCACAATGAACCCATCCATCGATATTTCCTATCCCTTGGATGAGTTG
  AAGATTGATACTGTCAATCGTGTGGTGGATGTAACCAAAACGGCTGGTGGTAAGGGACTC
  AATGTTACCCGAGTACTTTCAGAATTTGGCGATTCTGTTCTTGCTACTGGTTTAGTGGGT
  GGCAAACTTGGTGAGTTTTTGGTTGAACATATCGATAATCAAGTAAAGAAAGATTTCTTC
  TCAATTAAGGGAGAAACTCGTAACTGTATCGCTATTCTCCACGGAGACAACCAAACAGAA
  GTTCTTGAAAAAGGTCCTGAAGTATTGGAACAGGAAGGTCAAGAGTTTTTGGAACATTTC
  AAAAAACTCTTGGAGTCAGTTGAAGTAGTAGCCATCTCAGGTAGTCTGCCAGCTGGCCTT
  CCAGTTGATTACTATGCGAGCTTGGTAGAACTTGCTAATCAAGCTGGCAAGCATGTAGTC
  TTGGACTGCTCAGGTGCAGCACTTCAGGCTGTTCTTGAATCACCCCATAAACCAACAGTC
  ATCAAACCAAATAATGAAGAATTGTCTCAGCTTCTTGGAAGAGAAGTTTCTGAGGATTTG
  GATGAATTAAAAGAAGTACTTCAAGAACCTTTGTTTGCAGGGATTGAATGGATTATCGTT
  TCACTTGGTGCCAACGGTACTTTTGCCAAACATGGTGACACTTTCTACAAGGTAGATATT
  CCTAGAATTCAGGTGGTAAATCCTGTTGGATCTGGAGACTCTACTGTGGCAGGAATTTCT
  TCAGGACTTCTTCACAAAGAATCGGATGCAGAATTACTCATCAAGGCAAATGTCCTTGGT
  ATGCTCAATGCTCAAGAAAAAATGACTGGTCATGTCAACATGGCCAACTATCAAGCTCTA
  TATGATCAATTAATAGTAAAAGAGGTATAA
  60
  120
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  840
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  930
  

⊟Protein

⊟General

• locus tag: SP_1191 [new locus tag: SP_RS05855 ]
• symbol: LacC
• description: tagatose-6-phosphate kinase
• length: 309
• theoretical pI: 4.47108
• theoretical MW: 33439.9
• GRAVY: 0.0119741

⊟Function

• ⊞⊞reaction:
  EC 2.7.1.144?  ExPASy
  Tagatose-6-phosphate kinase ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate
• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides tagatose-6-phosphate kinase (TIGR01231; EC 2.7.1.144; HMM-score: 522.7)
  and 5 more
  hexose kinase, 1-phosphofructokinase family (TIGR03168; EC 2.7.1.-; HMM-score: 314.1)
  1-phosphofructokinase (TIGR03828; EC 2.7.1.56; HMM-score: 260.7)
  Metabolism Energy metabolism Sugars ribokinase (TIGR02152; EC 2.7.1.15; HMM-score: 59.7)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain I (TIGR02198; EC 2.7.1.-; HMM-score: 47.3)
  Metabolism Energy metabolism Sugars 5-dehydro-2-deoxygluconokinase (TIGR04382; EC 2.7.1.92; HMM-score: 46.9)
• TheSEED  :
  • Tagatose-6-phosphate kinase (EC 2.7.1.144)
  Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  Tagatose-6-phosphate kinase (EC 2.7.1.144)
• ⊞⊞PFAM:
  Ribokinase (CL0118) PfkB; pfkB family carbohydrate kinase (PF00294; HMM-score: 207.8)
  and 5 more
  Carb_kinase; Carbohydrate kinase (PF01256; HMM-score: 28.9)
  Phos_pyr_kin; Phosphomethylpyrimidine kinase (PF08543; HMM-score: 22.9)
  L27 (CL0614) L27; L27 domain (PF02828; HMM-score: 15.6)
  no clan defined Translat_reg; Bacteriophage translational regulator (PF01818; HMM-score: 12.8)
  MCR (CL0618) MCR_beta_N; Methyl-coenzyme M reductase beta subunit, N-terminal domain (PF02783; HMM-score: 12.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.010193
  • TAT(Tat/SPI): 0.000423
  • LIPO(Sec/SPII): 0.000296
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: AAK75300 NCBI
• UniProt: Q97QL2 UniProt

⊟Protein sequence

• MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTRVLSEFGDSVLATGLVGGKLGEFLVEHIDNQVKKDFFSIKGETRNCIAILHGDNQTEVLEKGPEVLEQEGQEFLEHFKKLLESVEVVAISGSLPAGLPVDYYASLVELANQAGKHVVLDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWIIVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKANVLGMLNAQEKMTGHVNMANYQALYDQLIVKEV

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: lacD < lacC < lacB < lacA

⊟Regulation

• ⊞⊞regulator: LacR* (repression) regulon

  LacR*

  (TF)

  important in Lactose utilization, Galactose utilization; RegPrecise

⊟Expression data

• PneumoExpress for strain D39V: SPV_1051 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications