⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 20-DEC-2020

⊟Summary

• organism: Streptococcus pneumoniae OXC141
locus tag: SPNOXC_RS09650 [old locus tags: SPNOXC17630 SPNOXC_17630 ]
pan locus tag^?: PNEUPAN003540000
symbol: SPNOXC_RS09650
pan gene symbol^?: yxlF
• synonym:
• product: ABC transporter ATP-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNOXC_RS09650 [old locus tags: SPNOXC17630 SPNOXC_17630 ]
• symbol: SPNOXC_RS09650
• product: ABC transporter ATP-binding protein
• replicon: chromosome
• strand: -
• coordinates: 1787547..1788431
• length: 885
• essential: unknown

⊟Accession numbers

• Location: NC_017592 (1787547..1788431) NCBI
• BioCyc: SPNOXC_RS09650 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1801 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  
  ATGACGGTGGTTAAAGTTGAAAAATTGAGTAAGAAAATAAAAGACAAGGAAATTTTGCGG
  AACATCTCCTTTGAAATCAACGATGGTGAATGTGTTGCCTTAATTGGTCCAAATGGTGCC
  GGAAAGACAACACTCTTAGATTGTTTGCTTGGAGATAAACTGGTCACAAGCGGTCAAGTA
  TCTATTCAAGGTTTACCAGTGACGAGTTCTAAGTTAGACTATACTAGGGCTTACCTCCCT
  CAAGAAAATGTAATCGTTCAGAAATTAAAAGTTAAAGAGTTGATTGCTTTCTTTCAACGT
  ATCTATCCAAATCCTTTGAGCAATCAGGAAATTGATCAACTATTGCAGTTTGTCAAGCAA
  CAAAAAGAACAGTTGGCAGAAAAATTATCAGGCGGTCAAAAGCGTCTCTTTTCTTTCGTC
  TTGACCTTAATTGGGCGACCAAAGATTGTTTTTTTAGATGAGCCTACTGCGTCCATGGAT
  ACCTCAACTCGTCAACGTTTTTGGGAAATTGTCCAGGAGTTAAAAGCGCAAGGAGTCACC
  ATTCTCTATTCGTCCCATTATATTGAGGAAGTGGAACACACTGCAGACCGCATTTTGCTC
  TTAAATAAGGGAGAGTTGATTCGAGATACGACGCCTCTAGCTATGCGTAGCGAGGAAATA
  GAAAAGCACTTTATCCTTCCTATAGCTTACAAGGAAGTCGTAGAGCAGTCAAATTTGGTT
  GAAAACTGGACCCTAAAGCAAGATTCTTTACAAGTAGTCACTCGAGAAGCAGATGCTTTC
  TGGGAACTATTAGCTCAAGCAGGATGTAGGATGCAAGAAATCGAAGTTAATAATCGTAGT
  TTGTTGAATACAATCTTTGAAGAGACGCAGAAGGGAGATAACTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  885
  

⊟Protein

⊟General

• locus tag: SPNOXC_RS09650 [old locus tags: SPNOXC17630 SPNOXC_17630 ]
• symbol: SPNOXC_RS09650
• description: ABC transporter ATP-binding protein
• length: 294
• theoretical pI: 5.29969
• theoretical MW: 33509.4
• GRAVY: -0.251361

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 151)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 127.1)
  Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 127.1)
  gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 121.8)
  and 77 more
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 120.6)
  Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 116.2)
  lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 115.6)
  Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 114.1)
  Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 114.1)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 112.9)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 110.7)
  Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 109.2)
  Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 105.6)
  Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 103.3)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 100.1)
  Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 100.1)
  Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 99.2)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 99.2)
  Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 99.1)
  Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 98.6)
  thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 97.1)
  Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 96.8)
  Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 96.8)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 94.3)
  Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 92.9)
  Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 92.2)
  ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 89.9)
  Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 89.9)
  Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 89.1)
  2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 88.4)
  Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 88.2)
  Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 87.9)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 85.8)
  Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 82.4)
  Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 80.6)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 78.9)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 77.8)
  Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 77.4)
  Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 76.7)
  ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 76.4)
  phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 75.8)
  proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 75.5)
  ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 74.8)
  Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 73.2)
  Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 73.2)
  Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 72.2)
  Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 72.2)
  D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 70.6)
  Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 70.5)
  ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 70.5)
  Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 67.1)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 65.5)
  Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 65.5)
  thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 64.6)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 63.4)
  Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 63.4)
  Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 63.4)
  Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 63.1)
  Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 63.1)
  Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 62.3)
  Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 60)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 57.4)
  Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 54.8)
  Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 54.8)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 53.2)
  Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 53.2)
  Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 50.1)
  Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 49)
  Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 47.3)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 28)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 22.3)
  Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 16.5)
  rad50 (TIGR00606; HMM-score: 16)
  Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 14.2)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA replication and repair protein RecF (TIGR00611; HMM-score: 14.1)
  Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 13.2)
  Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 13.2)
  type IV secretion/conjugal transfer ATPase, VirB4 family (TIGR00929; HMM-score: 13.1)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair exonuclease SbcC (TIGR00618; HMM-score: 12.6)
  Metabolism Central intermediary metabolism Phosphorus compounds phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN (TIGR02322; HMM-score: 12.1)
  helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 11)
• TheSEED: see SPNOXC17630
• ⊞⊞PFAM:
  P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 91.8)
  and 28 more
  AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 61.5)
  SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 34.3)
  AAA_16; AAA ATPase domain (PF13191; HMM-score: 25.8)
  AAA_23; AAA domain (PF13476; HMM-score: 25.2)
  RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 22.8)
  AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 21.8)
  AAA_15; AAA ATPase domain (PF13175; HMM-score: 20.6)
  Dynamin_N; Dynamin family (PF00350; HMM-score: 19.3)
  AAA_22; AAA domain (PF13401; HMM-score: 17.6)
  AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 17.2)
  SbcC_Walker_B; SbcC/RAD50-like, Walker B motif (PF13558; HMM-score: 16.8)
  IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 16)
  AAA_33; AAA domain (PF13671; HMM-score: 15.8)
  KdpD; Osmosensitive K+ channel His kinase sensor domain (PF02702; HMM-score: 15.7)
  TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 14.5)
  no clan defined PSD5; Protein of unknown function (DUF1595) (PF07637; HMM-score: 14.1)
  PilZN; Flagellar regulator YcgR, PilZN domain (PF07317; HMM-score: 13.9)
  P-loop_NTPase (CL0023) AAA_14; AAA domain (PF13173; HMM-score: 13.8)
  MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 13.3)
  AAA_24; AAA domain (PF13479; HMM-score: 13.2)
  no clan defined SpoVIF; Stage VI sporulation protein F (PF14069; HMM-score: 12.9)
  P-loop_NTPase (CL0023) DUF5906; Family of unknown function (DUF5906) (PF19263; HMM-score: 12.9)
  GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 12.7)
  AAA_28; AAA domain (PF13521; HMM-score: 12.6)
  DO-GTPase2; Double-GTPase 2 (PF19993; HMM-score: 12.5)
  cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 12.3)
  AAA_25; AAA domain (PF13481; HMM-score: 12.2)
  AAA_30; AAA domain (PF13604; HMM-score: 12)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.04
  • Cytoplasmic Membrane Score: 9.96
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.074931
  • TAT(Tat/SPI): 0.000396
  • LIPO(Sec/SPII): 0.000548
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000219356 NCBI
• UniProt:

⊟Protein sequence

• MTVVKVEKLSKKIKDKEILRNISFEINDGECVALIGPNGAGKTTLLDCLLGDKLVTSGQVSIQGLPVTSSKLDYTRAYLPQENVIVQKLKVKELIAFFQRIYPNPLSNQEIDQLLQFVKQQKEQLAEKLSGGQKRLFSFVLTLIGRPKIVFLDEPTASMDTSTRQRFWEIVQELKAQGVTILYSSHYIEEVEHTADRILLLNKGELIRDTTPLAMRSEEIEKHFILPIAYKEVVEQSNLVENWTLKQDSLQVVTREADAFWELLAQAGCRMQEIEVNNRSLLNTIFEETQKGDN

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1801 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications