⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 25-OCT-2019

⊟Summary

• organism: Streptococcus pneumoniae NU83127
locus tag: SPNU_1439 [new locus tag: EL277_RS07575 ]
pan locus tag^?: PNEUPAN002850000
symbol: patB
pan gene symbol^?: patB2
• synonym:
• product: Cystathionine beta-lyase PatB

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNU_1439 [new locus tag: EL277_RS07575 ]
• symbol: patB
• product: Cystathionine beta-lyase PatB
• replicon: chromosome
• strand: -
• coordinates: 1429994..1431160
• length: 1167
• essential: unknown

⊟Accession numbers

• Location: AP018936 (1429994..1431160) NCBI
• BioCyc: see EL277_RS07575
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1352 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGGGAAAATATGATTTTACAAGCCTGCCCAACCGTTTAGGGCACCATACCTATAAATGG
  AAAGAAACAGAAACGGATAGTGAAGTTCTACCAGCTTGGATAGCGGATATGGACTTTGTG
  GTCTTGCCTGAAATCCGCCAAGCCGTGCAAACTTACGCAGACCAACTGGTTTATGGTTAT
  ACCTATGCCAGTGAAGACTTAATTAAGGAAGTTCAAAAGTGGGAAGCTACACAATACGGT
  TACAACTTTGACAAAGAGGCTCTTGTCTTTATCGAGGGTGTGGTACCAGCCATCTCAACA
  GCTATTCAAACCTTTACAAAAGAAGGCGAGGCGGTTTTAATTAACACGCCTGTCTACCCA
  CCCTTTGCTCGCAGTGTCAAGTTGAATAATCGTAGATTGATTACTAATTCCTTAGTGGAA
  AAGGATAGTCTGTTTGAGATTGACTTTGACCAACTTGAAAAGGATTTGGTGGAAGAGGAG
  GTTAAACTCTATGTTCTTTGCAACCCTCACAATCCTGGTGGACGTGTTTGGGAAAAAGAA
  GTGTTGGAGAAGATTGGCCAACTCTGCCAAAAACACGGTGTTTTGTTAGTTTCGGATGAG
  ATTCACCAAGATTTGACCCTCTTTGGTCACAAACACCAGTCTTTCAATACCATCAATCCT
  GCCTTCAAAAATTTTGCTATCGTCTTGAGCAGTGCCACTAAAACATTTAATATTGCTGGA
  ACAAAAAATTCCTATGCAGTCATTGAAAATCCTAAGTTGAGACTGGCTTTCCAGAAACGC
  CTGTTGGCCAATAATCAGCATGAAATTTCAGGCTTGGGTTATTTGGCGACAGAAGCTGCC
  TATCGATACGGTAAAGATTGGCTAGAGGAACTCAAGCAAGTCTTTGAAGACCACATCAAT
  TATGTGATGGATCTATTTGGAAAAGAGACTAAAATCAAGGTCATGAAACCGCAAGGTACC
  TACTTGATTTGGCTTGACTTTTCAGCTTATGACCTGACTGATGAAACATTGCAAGAGTTG
  TTGAGAAATGAAGCCAAGGTTATCCTCAACCGTGGTTTGGATTTTGGAGAGGAAGGAAGT
  CTCCATGCCCGCATCAATATAGCTATGCCCAAATCTCTGTTGCAAGAAGTCTGTCAGCGG
  ATTGTGGCTACTTTTGCCAAACGTTAA
  60
  120
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  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1167
  

⊟Protein

⊟General

• locus tag: SPNU_1439 [new locus tag: EL277_RS07575 ]
• symbol: PatB
• description: Cystathionine beta-lyase PatB
• length: 388
• theoretical pI: 5.48169
• theoretical MW: 44511.5
• GRAVY: -0.28866

⊟Function

• ⊞⊞TIGRFAM:
  putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 392.6)
  and 19 more
  tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 104.2)
  LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 104.1)
  Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 93.1)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 71.8)
  succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 66.8)
  Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 61.6)
  LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 53.9)
  beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 52.6)
  succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 46.3)
  Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 42.7)
  succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 39.4)
  enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 31)
  enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 24.2)
  Metabolism Energy metabolism Amino acids and amines aspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 22.7)
  Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 20.8)
  ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 16.1)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin adenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 14.6)
  Metabolism Central intermediary metabolism Other 4-aminobutyrate transaminase (TIGR00700; EC 2.6.1.19; HMM-score: 13.1)
  transaminase, acetylornithine/succinylornithine family (TIGR00707; HMM-score: 13)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• ⊞⊞PFAM:
  PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 153.6)
  and 5 more
  Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 18)
  Aminotran_3; Aminotransferase class-III (PF00202; HMM-score: 14.4)
  Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 14)
  Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 12.3)
  no clan defined Frankia_peptide; Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. (PF14407; HMM-score: 12.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003434
  • TAT(Tat/SPI): 0.000212
  • LIPO(Sec/SPII): 0.000281
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBG35322 NCBI
• UniProt:

⊟Protein sequence

• MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEEVKLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFEDHINYVMDLFGKETKIKVMKPQGTYLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1352 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications