⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 25-OCT-2019

⊟Summary

• organism: Streptococcus pneumoniae NU83127
locus tag: SPNU_1453 [new locus tag: EL277_RS07645 ]
pan locus tag^?: PNEUPAN002822000
symbol: SPNU_1453
pan gene symbol^?: —
• synonym:
• product: Putative bifunctional

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNU_1453 [new locus tag: EL277_RS07645 ]
• symbol: SPNU_1453
• product: Putative bifunctional
• replicon: chromosome
• strand: -
• coordinates: 1443632..1445032
• length: 1401
• essential: unknown

⊟Accession numbers

• Location: AP018936 (1443632..1445032) NCBI
• BioCyc: see EL277_RS07645
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1367 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  
  ATGGACGCGAAATTAAGATACAAGGCAAAGAAGATCAAGATTGTCTTTTTTGATATTGAT
  GATACATTGCGGAATTCAAAGACAGGGTTTATTCCAACTACAATTCCCACTGTTTTTAAA
  CAGTTGCGTGAAAAAGGAATTTTAACAGGAATCGCCTCTGGACGTGGCATTTTTGGTGTT
  GTTCCAGAGATTCGTGATCTCAAGCCTGACTTTTTTGTAACTTTGAATGGGGCTTATATC
  GAAGATAAAAAAGGTCAGGTCATTTATCAGCATCAGATTGAAAAGTCAGATGTTGAGGAG
  TATATCTCTTGGGCTAAGCAAGAAGGAATTGAGTATGGCTTGGTTGGGAGTCATGATGCC
  AAGTTGTCGACTCGCACCGATATGATGAGTGAAGCTATCAATCCAATTTATCCCGACTTA
  GATGTAGATCCCGATTTCCATGAAAAAGAAGATATCTATCAGATGTGGACTTTTGAAGAT
  AAGGGAGATGACTTGCACTTGCCTGACAGTCTCTCAGACAAACTTCGCATGGTTCGTTGG
  CATCAACATTCGTCTGATATTGTGCCGATTTCAGGCTCCAAAGCGACGGGGGTGGAAAAG
  GTTGTGGAACACCTTGGCTTGAAACCAGAGAAGGTCATGGTTTTTGGAGATGGTCTCAAC
  GACTTGGAACTCTTTGATTATGCTGGAATCAGCGTTGCCATGGGAATTTCTCATGATAAA
  ATCAAAGAAAAAGCAGATTATATTACAAAAACATTAGAAGAAGATGGCATTTTTGCTGCC
  TTAGAAGTATTTGGTATGGTAGAAAAAGAATTGCATTTTCCACAAGTAGACATTGAAACA
  GTAGAAGGTCCTCTTGCGACTATTAAGACCAATCACGGAGACTTACGTATCAAGCTTTTC
  CCTGAACATGCTCCTAAAACAGTGGCTAACTTTGTATCTCTTTCAAAAGATGGCTACTAT
  GATGGTGTCATTTTCCACCGTATTATCAAGGACTTTATGATCCAAGGTGGAGACCCAACT
  GGAACTGGTATGGGTGGCGAGTCAATCTACGGCGAATCTTTTGAGGATGAATTCTCAGAA
  GAGCTTTACAATATCCGTGGTGCTCTTTCCATGGCAAATGCTGGTCCAAATACCAACGGC
  AGCCAGTTCTTTATCGTGCAAAACCAACACCTACCTTATTCTAAGAAAGAAATTACTCGT
  GGTGGTTGGCCAGAACCGATTGCAGAAATCTATGCCAATCAAGGTGGGACACCTCACCTA
  GACCGCCGTCACACGGTTTTTGGTCAGTTAGCTGATGAAGCATCTTACGCTGTCTTGGAT
  GCCATTGCTGCTGTTGAGACAGGAGCTATGGACAAGCCAGTTGAAGATGTTGTAATTGAA
  ACTATTGAAATCGAGGACTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1401
  

⊟Protein

⊟General

• locus tag: SPNU_1453 [new locus tag: EL277_RS07645 ]
• symbol: SPNU_1453
• description: Putative bifunctional
• length: 466
• theoretical pI: 4.57289
• theoretical MW: 52072.4
• GRAVY: -0.333906

⊟Function

• ⊞⊞TIGRFAM:
  Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 174.4)
  and 22 more
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIB (TIGR01484; HMM-score: 77.7)
  phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 76)
  sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 57.8)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 30.1)
  Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 28.7)
  sucrose-phosphate synthase, sucrose phosphatase-like domain (TIGR02471; HMM-score: 21.7)
  Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 20.7)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IIIA (TIGR01662; HMM-score: 20.2)
  heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 19.7)
  Metabolism Energy metabolism Anaerobic phenylphosphate carboxylase, delta subunit (TIGR02726; HMM-score: 19.2)
  Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 18.6)
  sucrose phosphatase (TIGR01485; EC 3.1.3.24; HMM-score: 18.5)
  Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 17.9)
  phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 16.9)
  HAD hydrolase, TIGR02253 family (TIGR02253; HMM-score: 15.1)
  HAD phosphatase, family IIIA (TIGR01668; EC 3.1.3.-; HMM-score: 14.8)
  Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 14.4)
  Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 14.4)
  calcium-transporting P-type ATPase, PMR1-type (TIGR01522; EC 3.6.3.8; HMM-score: 12.7)
  mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 11.5)
  Metabolism Energy metabolism ATP-proton motive force interconversion Na,H/K antiporter P-type ATPase, alpha subunit (TIGR01106; EC 3.6.3.-; HMM-score: 11.3)
  HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 10.9)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• ⊞⊞PFAM:
  HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 181.2)
  Cyclophil-like (CL0475) Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (PF00160; HMM-score: 160.6)
  and 6 more
  HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 37.7)
  S6PP; Sucrose-6F-phosphate phosphohydrolase (PF05116; HMM-score: 33.5)
  HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 25.7)
  HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 17.7)
  Glyco_hydro_tim (CL0058) Glyco_hydro_97; Glycoside hydrolase 97 (PF10566; HMM-score: 14.2)
  HAD (CL0137) Acid_phosphat_B; HAD superfamily, subfamily IIIB (Acid phosphatase) (PF03767; HMM-score: 11.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9981
  • Cytoplasmic Membrane Score: 0.0004
  • Cell wall & surface Score: 0
  • Extracellular Score: 0.0014
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003874
  • TAT(Tat/SPI): 0.00022
  • LIPO(Sec/SPII): 0.000586
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: BBG35336 NCBI
• UniProt:

⊟Protein sequence

• MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLREKGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSDVEEYISWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFEDKGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDGLNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFAALEVFGMVEKELHFPQVDIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMIQGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLPYSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDAIAAVETGAMDKPVEDVVIETIEIED

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1367 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications