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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_0044 [new locus tag: SPCG_RS00265 ]
  • pan locus tag?: PNEUPAN000692000
  • symbol: comA
  • pan gene symbol?: comA
  • synonym:
  • product: competence factor transporting ATP-binding/permease protein ComA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_0044 [new locus tag: SPCG_RS00265 ]
  • symbol: comA
  • product: competence factor transporting ATP-binding/permease protein ComA
  • replicon: chromosome
  • strand: +
  • coordinates: 42291..44471
  • length: 2181
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    TTGAGTATTAGGGAAAAGGAGATGAATATGAAATTTGGGAAACGTCACTATCGTCCGCAA
    GTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGATTTTTGGCTACTATGGTAGT
    TATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCT
    TTGGGCTTGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGAT
    ATGACGCTTTTTGACTTGCCGGATTTGACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAA
    GGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAGCATTCATATTGCC
    GATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGG
    ACAGGAGTGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAA
    AATGGTCTGCTCTCTTTTATCCCTATATTAGTGAAGCAGCGTGGCTTGATTGCCAATATC
    GTTTTGGCAACACTCTTGGTAATCGGGATTAACATTGTGGGTTCTTATTATCTGCAGTCT
    ATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGG
    CTAGTCATCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTT
    GTTTTGGGGCAACGCTTGTCGATTGACGTGATTTTGTCCTATATCAAGCATGTTTTTCAC
    CTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTCTCGTTTTACAGAT
    GCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCA
    ACGGTTGTCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACT
    TTATTGGCGCTTCCTATCTACACAGTGATTATCTTTGCCTTTATGAAGCCGTTTGAAAAG
    ATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTATCATTGAGGACATC
    AACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGAC
    AAGGAATTTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAA
    AAGGCTCTGAAAAAGGTTGCCCATCTCTTGCTTAATGTCGGCATTCTCTGGATGGGGGCT
    GTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTATAATACCTTGCTG
    GTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCG
    CAGGTTGCCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAG
    AAAACAGTTGAGGATTTGAGCTTGATGAAGGGAGATATGACCTTCAAGCAGGTTCATTAC
    AAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGTTCCCCAAGGGTCT
    AAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTT
    AATTTTTACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATT
    GATAAAAAAGCCCTGCGCCAGTACATCAACTATCTGCCTCAACAGCCCTATGTCTTTAAC
    GGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGACACAGGAAGATATC
    TTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTAC
    CAGACAGAATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCT
    TTGGCGCGTGCTCTCTTGACAGATGCGCCGGTCTTGATTTTGGATGAGGCGACTAGCAGT
    TTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTTGGACAAGACCTTG
    ATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGAT
    CAGGGCAAGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTAC
    GCCCATTTGGTCAATAGCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2181

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_0044 [new locus tag: SPCG_RS00265 ]
  • symbol: ComA
  • description: competence factor transporting ATP-binding/permease protein ComA
  • length: 726
  • theoretical pI: 6.26751
  • theoretical MW: 81497.2
  • GRAVY: 0.110193

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 1123.7)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 1123.7)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 1123.7)
    and 69 more
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 488.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 488.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 410.9)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 379)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 379)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 356.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 344.9)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 344.9)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 317.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 317.7)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 315.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 249.9)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 233.8)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 225.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 217.8)
    Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 166.2)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 118.8)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 116.7)
    Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 115.7)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 111.6)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 111.3)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 108.4)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 105.9)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 105)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 105)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 104.7)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 96.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 94.6)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 94.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 90.9)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 90.8)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 89.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 88.7)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 88.7)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 87.3)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 86.7)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 84.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 84)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 84)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 81.4)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 80)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 80)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 79.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 74.2)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 74.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 73.8)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 73.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 72.6)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 72.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 72.4)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 71.4)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 71.4)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 69)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 67.3)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 66.4)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 66.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 65.5)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 65.5)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 63.8)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 62.4)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 61.1)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 58)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 53.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 52)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 47.4)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 46.3)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 37.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 27.3)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 12.3)
  • TheSEED  :
    • Competence-stimulating peptide ABC transporter ATP-binding protein ComA
    DNA Metabolism DNA uptake, competence Competence in Streptococci  Competence-stimulating peptide ABC transporter ATP-binding protein ComA
  • ⊞PFAM:
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 210.5)
    and 10 more
    Peptidase_CA (CL0125) Peptidase_C39; Peptidase C39 family (PF03412; HMM-score: 142.4)
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 111.2)
    Peptidase_CA (CL0125) Peptidase_C70; Papain-like cysteine protease AvrRpt2 (PF12385; HMM-score: 24.8)
    P-loop_NTPase (CL0023) ABC_ATPase; ATPase of the ABC class (PF09818; HMM-score: 19)
    AAA_22; AAA domain (PF13401; HMM-score: 18.2)
    AAA_24; AAA domain (PF13479; HMM-score: 17.3)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 16.3)
    AAA_33; AAA domain (PF13671; HMM-score: 14.2)
    Peptidase_CA (CL0125) Peptidase_C39_2; Peptidase_C39 like family (PF13529; HMM-score: 13.6)
    no clan defined PrgI; PrgI family protein (PF12666; HMM-score: 7.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004689
    • TAT(Tat/SPI): 0.000191
    • LIPO(Sec/SPII): 0.000533
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACB89296 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSIREKEMNMKFGKRHYRPQVDQMDCGVASLAMIFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPILVKQRGLIANIVLATLLVIGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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