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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_RS05645 [old locus tag: SP670_1142 ]
  • pan locus tag?: PNEUPAN002356000
  • symbol: pezT
  • pan gene symbol?: pezT_2
  • synonym:
  • product: type II toxin-antitoxin system toxin PezT

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_RS05645 [old locus tag: SP670_1142 ]
  • symbol: pezT
  • product: type II toxin-antitoxin system toxin PezT
  • replicon: chromosome
  • strand: -
  • coordinates: 1063602..1064372
  • length: 771
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014498 (1063602..1064372) NCBI
  • BioCyc: SP670_RS05645 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGAAATCCAAGATTATACTGATAGTAAATTCAAACATGCTCTAGCACGGAATCTTCGT
    TCACTGACAAGAGGAAAAAAGTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAA
    AGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGAAAGAATTTCAAGGAAATATT
    GTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCGA
    GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCT
    TTACTAACCGAATTTAGTCATTTGGGATACAATCTTTTGATTGAAGGAACTTTACGAACA
    ATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTAGGGGATATGAAGTACAATTA
    GCCTTGATTGCGACAAAGCCTAAGTTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
    CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATT
    GTAAATCATCTAGTTGATAATACACGACAATTGGAAGAATTGGCTATCTTTGAAAGAATT
    CAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAGGAGAAGATAAAATTTCAGCA
    GCAAAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
    AAGGTGGGAGAAGAAAGATTGGAAGATTTAACTAATCGAAATGATTGTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    771

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_RS05645 [old locus tag: SP670_1142 ]
  • symbol: PezT
  • description: type II toxin-antitoxin system toxin PezT
  • length: 256
  • theoretical pI: 8.20062
  • theoretical MW: 29495.3
  • GRAVY: -0.598437

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 16.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 16.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 14.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 14.2)
    and 5 more
    helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 13.2)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 13.1)
    Cellular processes Cellular processes Sporulation and germination stage V sporulation protein K (TIGR02881; HMM-score: 12.8)
    Genetic information processing Protein synthesis tRNA aminoacylation L-seryl-tRNA(Sec) kinase (TIGR03574; EC 2.7.1.164; HMM-score: 12.7)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 12.1)
  • TheSEED: see SP670_1142
  • ⊞PFAM:
    P-loop_NTPase (CL0023) Zeta_toxin; Zeta toxin (PF06414; HMM-score: 207.3)
    and 10 more
    AAA_33; AAA domain (PF13671; HMM-score: 18.8)
    APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 17.4)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 16.3)
    PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 16)
    G-alpha; G-protein alpha subunit (PF00503; HMM-score: 15.2)
    AAA_17; AAA domain (PF13207; HMM-score: 14.9)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 14.7)
    CPT; Chloramphenicol phosphotransferase-like protein (PF07931; HMM-score: 14.4)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 13.9)
    AAA_24; AAA domain (PF13479; HMM-score: 13.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9483
    • Cytoplasmic Membrane Score: 0.0313
    • Cell wall & surface Score: 0.003
    • Extracellular Score: 0.0174
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018382
    • TAT(Tat/SPI): 0.001788
    • LIPO(Sec/SPII): 0.02604
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000405382 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEIQDYTDSKFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQREYGKDSVEYTKDFAGKMVESLLTEFSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEELYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSGEDKISAAKVLQEYLFGKWSKVEEEMLKVGEERLEDLTNRNDC

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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