⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 17-JAN-2018

⊟Summary

• organism: Streptococcus pneumoniae AP200
locus tag: SPAP_1486 [new locus tag: SPAP_RS07315 ]
pan locus tag^?: PNEUPAN002782000
symbol: SPAP_1486
pan gene symbol^?: trxB
• synonym:
• product: Thioredoxin reductase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPAP_1486 [new locus tag: SPAP_RS07315 ]
• symbol: SPAP_1486
• product: Thioredoxin reductase
• replicon: chromosome
• strand: -
• coordinates: 1399196..1400107
• length: 912
• essential: unknown

⊟Accession numbers

• Location: CP002121 (1399196..1400107) NCBI
• BioCyc: see SPAP_RS07315
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1287 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  481
  541
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  901
  
  ATGTACGATACTATTATTATCGGTGCTGGACCTGCAGGGATGACTGCGGCCTTGTATGCT
  GCTCGAAGCAATCTAAAAGTAGCTTTGATTGAAGGTGGTCTGCCAGGTGGTCAGATGAAT
  AATACATCTGATATCGAAAATTACCCAGGATACGCTAATATTAGTGGACCTGAATTGGCT
  GAAAAGATGTTTGAACCACTTGAAAATCTTGGTGTTGAGCACATTTATGGTTATGTTGAA
  AATGTCGAAGACCATGGTGATTTTAAGAAAGTGATGACTGATGACCAAACATATGAAACA
  CGTACAGTTATCGTAGCAACTGGTTCTAAACACCGTCCTTTGGGAGTGCCTGGAGAAGAA
  GAACTGAACAGTCGTGGTGTTTCTTACTGTGCTGTGTGTGATGGTGCTTTCTTCCGTGAC
  CAAGATTTATTGATAGTTGGTGGTGGAGATTCAGCTGTTGAAGAAGCCCTCTTCTTGACT
  CGTTTTGCTAAGACTGTTACCATTGTTCACCGTCGTGACCAACTTCGTGCCCAAAAGGTT
  TTACAAGATCGCGCCTTTGCGAATGAAAAAATCAGCTTTATCTGGGATTCTGTAGTAAGG
  GAAATCAAGGGTGAAAACCGAGTAGAATCAGTCGTATTTGAAAATGTGAAAACAGGTCAA
  GTGACAGAACAAGCCTTCGGTGGTGTCTTTATCTATGTTGGTTTGGACCCTCTTAGCGAT
  TTTGTTAAAGAATTGAATATCCAAGATCAGGCAGGCTGGATTGTGACAGATAGCCACATG
  AAGACTGCAGTCGACGGTATCTTTGCAGTTGGAGATGTTCGCTTGAAAGACCTTCGCCAA
  GTAACAACAGCAGTTGGAGATGGAGCTATCGCTGGTCAAGAAGCCTACAAGTTTATCACA
  GAACATAGTTAA
  60
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  912
  

⊟Protein

⊟General

• locus tag: SPAP_1486 [new locus tag: SPAP_RS07315 ]
• symbol: SPAP_1486
• description: Thioredoxin reductase
• length: 303
• theoretical pI: 4.50525
• theoretical MW: 33134.1
• GRAVY: -0.155776

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 388.6)
  putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 321.1)
  and 44 more
  Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 241.6)
  Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 241.6)
  Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 95.5)
  dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 94)
  Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 70.3)
  thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 54)
  Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 52.2)
  Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 46.9)
  Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 45.7)
  Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 41)
  putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 41)
  mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 39.5)
  Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 35.8)
  Metabolism Amino acid biosynthesis Glutamate family glutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 35.2)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 33.9)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis enzyme (TIGR00292; HMM-score: 32.7)
  mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 28.8)
  mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 27.9)
  lycopene cyclase family protein (TIGR01790; HMM-score: 26.8)
  Metabolism Central intermediary metabolism Nitrogen metabolism nitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 24.2)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 23.6)
  trypanothione-disulfide reductase (TIGR01423; EC 1.8.1.12; HMM-score: 21.9)
  Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 20.1)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 20)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenyl-6-methoxyphenol 4-hydroxylase (TIGR01984; EC 1.14.13.-; HMM-score: 19.8)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides L-aspartate oxidase (TIGR00551; EC 1.4.3.16; HMM-score: 19.2)
  flavin-dependent oxidoreductase, MSMEG_0569 family (TIGR04046; HMM-score: 18.6)
  Metabolism Energy metabolism TCA cycle succinate dehydrogenase, flavoprotein subunit (TIGR01816; HMM-score: 18)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02023; EC 1.3.1.-; HMM-score: 17.5)
  Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, B subunit (TIGR03378; EC 1.1.5.3; HMM-score: 17.2)
  Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.1)
  Metabolism Energy metabolism Anaerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.1)
  Metabolism Energy metabolism Aerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.1)
  squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 16.2)
  Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, beta subunit family (TIGR01373; HMM-score: 15.6)
  glutamate synthase, NADH/NADPH, small subunit (TIGR01317; EC 1.4.1.-; HMM-score: 14.9)
  Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 14.9)
  FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 14.7)
  fumarate reductase (quinol), flavoprotein subunit (TIGR01176; EC 1.3.5.4; HMM-score: 14.3)
  glutamate synthase, small subunit (TIGR01318; HMM-score: 14)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-galactopyranose mutase (TIGR00031; EC 5.4.99.9; HMM-score: 13.5)
  Metabolism Energy metabolism Electron transport flavocytochrome c (TIGR01813; HMM-score: 13.4)
  Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 12.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin 3B synthase CobZ (TIGR02485; HMM-score: 11.6)
• ⊞⊞TheSEED  :
  • Thioredoxin reductase (EC 1.8.1.9)
  Nucleosides and Nucleotides Pyrimidines pyrimidine conversions  Thioredoxin reductase (EC 1.8.1.9)
  and 1 more
  Sulfur Metabolism Sulfur Metabolism - no subcategory Thioredoxin-disulfide reductase  Thioredoxin reductase (EC 1.8.1.9)
• ⊞⊞PFAM:
  NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 166.6)
  and 15 more
  Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 97.7)
  Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 77.6)
  DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 44.8)
  FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 36.7)
  FAD_binding_2; FAD binding domain (PF00890; HMM-score: 35.7)
  GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 34.9)
  HI0933_like; HI0933-like protein (PF03486; HMM-score: 33.1)
  Lycopene_cycl; Lycopene cyclase protein (PF05834; HMM-score: 31)
  Thi4; Thi4 family (PF01946; HMM-score: 29.8)
  NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 27.4)
  NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 20.1)
  NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 19.9)
  FAD_binding_3; FAD binding domain (PF01494; HMM-score: 18.9)
  Trp_halogenase; Tryptophan halogenase (PF04820; HMM-score: 12.4)
  MCRA; MCRA family (PF06100; HMM-score: 11.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.123075
  • TAT(Tat/SPI): 0.022348
  • LIPO(Sec/SPII): 0.052237
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ADM85072 NCBI
• UniProt:

⊟Protein sequence

• MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSDIENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRTVIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLIVGGGDSAVEEALFLTRFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKTGQVTEQAFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDSHMKTAVDGIFAVGDVRLKDLRQVTTAVGDGAIAGQEAYKFITEHS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1287 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications