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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 21-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_RS07400 [old locus tag: SPD_1392 ]
  • pan locus tag?: PNEUPAN002847000
  • symbol: cdaA
  • pan gene symbol?: disA
  • synonym:
  • product: diadenylate cyclase CdaA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_RS07400 [old locus tag: SPD_1392 ]
  • symbol: cdaA
  • product: diadenylate cyclase CdaA
  • replicon: chromosome
  • strand: -
  • coordinates: 1413153..1414010
  • length: 858
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_008533 (1413153..1414010) NCBI
  • BioCyc: G1G6V-1512 BioCyc
  • MicrobesOnline: see SPD_1392
  • PneumoBrowse for strain D39V: SPV_1392 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAATTTTCAACAATTATCCAATCTGCAATATTGGACCAGTTTGTTTGCAAGTCCATGG
    ACGATAGCTATCAATCTGATTGATATTTTGATTGTTGCTTATATTTTATACCATTTTACA
    AAAGCTATTGCAGGAACCAAGATTATGATTTTGGTACGTGGAGTTTTGGTGTTTATTTTA
    GCCCAAATCCTTGCAAATATGATTGGTTTGACTACGATTTCTTGGTTAATCAATCAAATT
    ATTACTTATGGGGTTATTGCGGCGGTTGTTATCTTCTCTCCAGAGATTCGGACTGGTTTG
    GAACGTTTGGGAAGAGCGACAGATTTCTTTTCCAATGCCCCTATTAGTGCTGAGGAACAG
    ATGATTCGTGCCTTTGTTAAGTCTGTTGAATACATGAGTCCTCGTAAAATCGGGGCCTTG
    GTTGCTATTCAGCGTGTACGTACCTTGCAGGAGTATATTTCGACAGGAATTCCCTTGGAT
    GCTAAGATTTCTGCAGAACTTCTCATTAACATTTTTATTCCCAACACTCCCCTACATGAT
    GGTGCGGTGATTATCAAAGAAGAACGTATCGCTGTGACGTCTGCCTATCTGCCCTTGACA
    AAAAACACAGGGATTTCCAAGGAATTTGGGACCAGACACCGGGCGGCTATCGGTTTATCA
    GAAGTCTCAGATGCCTTGACTTTTGTCGTATCAGAGGAAACGGGAGGAATTTCGATAACC
    TATAATGGAAGGTTTAAGCACAACCTAACACTTGATGAATTTGAAACAGAATTACGTGAA
    ATCTTACTTCCAAAAGAGGAAGTGGGTCTTAGTTTTAAAGAACGATTGCTAGGAGGATGG
    AAACATGAAAAAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    858

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_RS07400 [old locus tag: SPD_1392 ]
  • symbol: CdaA
  • description: diadenylate cyclase CdaA
  • length: 285
  • theoretical pI: 8.73472
  • theoretical MW: 31853
  • GRAVY: 0.316842

⊟Function[edit | edit source]

  • ⊞⊞reaction:
    EC 2.7.7.85?  ExPASy
    Diadenylate cyclase 2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate
  • TIGRFAM:
    Hypothetical proteins Conserved TIGR00159 family protein (TIGR00159; HMM-score: 268.9)
  • TheSEED: see SPD_1392
  • ⊞⊞PFAM:
    no clan defined DAC; DisA bacterial checkpoint controller nucleotide-binding (PF02457; HMM-score: 138.5)
    and 1 more
    CdaA_N; CdaA N-terminal transmembrane domain (PF19293; HMM-score: 30)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 3
  • ⊞⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9995
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0005
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001061
    • TAT(Tat/SPI): 0.000086
    • LIPO(Sec/SPII): 0.002227
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIAGTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLERLGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYISTGIPLDAKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIGLSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERLLGGWKHEKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPD_RS07400&oldid=5910"
Insert paragraph

NCBI: 21-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_RS07400 [old locus tag: SPD_1392 ]
  • pan locus tag?: PNEUPAN002847000
  • symbol: cdaA
  • pan gene symbol?: disA
  • synonym:
  • product: diadenylate cyclase CdaA

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_RS07400 [old locus tag: SPD_1392 ]
  • symbol: cdaA
  • product: diadenylate cyclase CdaA
  • replicon: chromosome
  • strand: -
  • coordinates: 1413153..1414010
  • length: 858
  • essential: unknown other strains

Insert paragraph

⊟Accession numbers[edit | edit source]

  • Location: NC_008533 (1413153..1414010) NCBI
  • BioCyc: G1G6V-1512 BioCyc
  • MicrobesOnline: see SPD_1392
  • PneumoBrowse for strain D39V: SPV_1392 PneumoBrowse

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAATTTTCAACAATTATCCAATCTGCAATATTGGACCAGTTTGTTTGCAAGTCCATGG
    ACGATAGCTATCAATCTGATTGATATTTTGATTGTTGCTTATATTTTATACCATTTTACA
    AAAGCTATTGCAGGAACCAAGATTATGATTTTGGTACGTGGAGTTTTGGTGTTTATTTTA
    GCCCAAATCCTTGCAAATATGATTGGTTTGACTACGATTTCTTGGTTAATCAATCAAATT
    ATTACTTATGGGGTTATTGCGGCGGTTGTTATCTTCTCTCCAGAGATTCGGACTGGTTTG
    GAACGTTTGGGAAGAGCGACAGATTTCTTTTCCAATGCCCCTATTAGTGCTGAGGAACAG
    ATGATTCGTGCCTTTGTTAAGTCTGTTGAATACATGAGTCCTCGTAAAATCGGGGCCTTG
    GTTGCTATTCAGCGTGTACGTACCTTGCAGGAGTATATTTCGACAGGAATTCCCTTGGAT
    GCTAAGATTTCTGCAGAACTTCTCATTAACATTTTTATTCCCAACACTCCCCTACATGAT
    GGTGCGGTGATTATCAAAGAAGAACGTATCGCTGTGACGTCTGCCTATCTGCCCTTGACA
    AAAAACACAGGGATTTCCAAGGAATTTGGGACCAGACACCGGGCGGCTATCGGTTTATCA
    GAAGTCTCAGATGCCTTGACTTTTGTCGTATCAGAGGAAACGGGAGGAATTTCGATAACC
    TATAATGGAAGGTTTAAGCACAACCTAACACTTGATGAATTTGAAACAGAATTACGTGAA
    ATCTTACTTCCAAAAGAGGAAGTGGGTCTTAGTTTTAAAGAACGATTGCTAGGAGGATGG
    AAACATGAAAAAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    858

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_RS07400 [old locus tag: SPD_1392 ]
  • symbol: CdaA
  • description: diadenylate cyclase CdaA
  • length: 285
  • theoretical pI: 8.73472
  • theoretical MW: 31853
  • GRAVY: 0.316842

Insert paragraph

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.7.85?  ExPASy
    Diadenylate cyclase 2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate
  • TIGRFAM:
    Hypothetical proteins Conserved TIGR00159 family protein (TIGR00159; HMM-score: 268.9)
  • TheSEED: see SPD_1392
  • ⊞PFAM:
    no clan defined DAC; DisA bacterial checkpoint controller nucleotide-binding (PF02457; HMM-score: 138.5)
    and 1 more
    CdaA_N; CdaA N-terminal transmembrane domain (PF19293; HMM-score: 30)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 3
  • ⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9995
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0005
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001061
    • TAT(Tat/SPI): 0.000086
    • LIPO(Sec/SPII): 0.002227
  • predicted transmembrane helices (TMHMM): 3

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIAGTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLERLGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYISTGIPLDAKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIGLSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERLLGGWKHEKK

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • regulator:

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph