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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS08975 [old locus tag: SP_1808 ]
  • pan locus tag?: PNEUPAN003327000
  • symbol: SP_RS08975
  • pan gene symbol?: cclA
  • synonym:
  • product: prepilin peptidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS08975 [old locus tag: SP_1808 ]
  • symbol: SP_RS08975
  • product: prepilin peptidase
  • replicon: chromosome
  • strand: +
  • coordinates: 1721522..1722181
  • length: 660
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (1721522..1722181) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_1808
  • PneumoBrowse for strain D39V: SPV_1593 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTC
    ATTGACCGTTTTCCAGAGCAATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAG
    ACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCACAGGTCTTCAATCGCTTTCGC
    TGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAAGCTTAGGA
    CTCCTCTTTCTGCTTTACTCTTGGGGATGGCTCTCCTTGGGGCAAGTCGTCCTAATCACC
    GCTGGTTTGACCTTGGGTATCTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGG
    ATGACTTTCCAGCTAATCCTAATAGCTTCCTCTGGCTGGAATCTGGTCATGGTCTCCTTC
    CTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTC
    TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTC
    GCTTCTGCGACGGGTATCCTGGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTC
    GTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTGGTAAGCTACTGCTTGTCTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS08975 [old locus tag: SP_1808 ]
  • symbol: SP_RS08975
  • description: prepilin peptidase
  • length: 219
  • theoretical pI: 7.80657
  • theoretical MW: 24842.8
  • GRAVY: 1.04658

⊟Function[edit | edit source]

  • ⊞⊞reaction:
    EC 3.4.23.43?  ExPASy
    Prepilin peptidase Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine
  • TIGRFAM:
  • TheSEED: see SP_1808
  • PFAM:
    no clan defined DiS_P_DiS; Bacterial Peptidase A24 N-terminal domain (PF06750; HMM-score: 82.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • ⊞⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0113
    • Cytoplasmic Membrane Score: 0.9828
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0059
  • ⊞⊞SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.467934
    • TAT(Tat/SPI): 0.086269
    • LIPO(Sec/SPII): 0.030949
    • Cleavage Site: CS pos: 33-34. SSA-SH. Pr: 0.2387
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELSLGLLFLLYSWGWLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFQLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFLFLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP_RS08975&oldid=1745"
Insert paragraph

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS08975 [old locus tag: SP_1808 ]
  • pan locus tag?: PNEUPAN003327000
  • symbol: SP_RS08975
  • pan gene symbol?: cclA
  • synonym:
  • product: prepilin peptidase

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS08975 [old locus tag: SP_1808 ]
  • symbol: SP_RS08975
  • product: prepilin peptidase
  • replicon: chromosome
  • strand: +
  • coordinates: 1721522..1722181
  • length: 660
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (1721522..1722181) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_1808
  • PneumoBrowse for strain D39V: SPV_1593 PneumoBrowse

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTC
    ATTGACCGTTTTCCAGAGCAATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAG
    ACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCACAGGTCTTCAATCGCTTTCGC
    TGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAAGCTTAGGA
    CTCCTCTTTCTGCTTTACTCTTGGGGATGGCTCTCCTTGGGGCAAGTCGTCCTAATCACC
    GCTGGTTTGACCTTGGGTATCTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGG
    ATGACTTTCCAGCTAATCCTAATAGCTTCCTCTGGCTGGAATCTGGTCATGGTCTCCTTC
    CTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTC
    TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTC
    GCTTCTGCGACGGGTATCCTGGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTC
    GTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTGGTAAGCTACTGCTTGTCTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS08975 [old locus tag: SP_1808 ]
  • symbol: SP_RS08975
  • description: prepilin peptidase
  • length: 219
  • theoretical pI: 7.80657
  • theoretical MW: 24842.8
  • GRAVY: 1.04658

Insert paragraph

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 3.4.23.43?  ExPASy
    Prepilin peptidase Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine
  • TIGRFAM:
  • TheSEED: see SP_1808
  • PFAM:
    no clan defined DiS_P_DiS; Bacterial Peptidase A24 N-terminal domain (PF06750; HMM-score: 82.6)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • ⊞DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0113
    • Cytoplasmic Membrane Score: 0.9828
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0059
  • ⊞SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.467934
    • TAT(Tat/SPI): 0.086269
    • LIPO(Sec/SPII): 0.030949
    • Cleavage Site: CS pos: 33-34. SSA-SH. Pr: 0.2387
  • predicted transmembrane helices (TMHMM): 5

Insert paragraph

⊟Accession numbers[edit | edit source]

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELSLGLLFLLYSWGWLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFQLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFLFLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph