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serotype 4
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serotype 2
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serotype 19A
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serotype 19F
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serotype 6B
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serotype 6A
70585
serotype 5
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serotype 11A
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serotype 23F
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serotype 19F
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serotype 19A
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INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
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NU83127
serotype 4
OXC141
serotype 3
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R6
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serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_1497 [new locus tag: SPG_RS07460 ]
  • pan locus tag?: PNEUPAN002955000
  • symbol: folA
  • pan gene symbol?: folA
  • synonym:
  • product: dihydrofolate reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_1497 [new locus tag: SPG_RS07460 ]
  • symbol: folA
  • product: dihydrofolate reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1443032..1443538
  • length: 507
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGACTAAGAAAATCGTAGCTATTTGGGCCCAGGATGAAGAGGGTGTGATTGGTAAGGAA
    AATCGTCTGCCTTGGCATTTGCCAGCAGAATTGCAGCACTTTAAAGAAACAACTCTGAAT
    CATGCTATCTTGATGGGGCGTGTGACCTTTGATGGGATGGGGCGTCGCTTGCTTCCAAAA
    CGGGAAACCTTGATTTTGACGCGTAATCCGGAAGAAAAGATAGATGGGGTTGCTACTTTT
    CAGGACGTCCAGTCTGTTCTTGACTGGTATCAGGCTCAAGAAAAGAATCTCTACATTATC
    GGTGGGAAGCAAATTTTTCAGGCTTTTGAAGCTTACCTTGATGAAGTGATTGTCACTCAC
    ATTCATGCTCGGGTGGAAGGAGATACCTATTTCCCTGAAGAACTTGACTTGTCTCTTTTT
    GAGACAGTTTCAAGCAAATTTTACGCCAAAGATGAGAAGAATCCTTATGATTTTACCATC
    CAATACCGCAAGAGAAAGGAAGTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    507

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_1497 [new locus tag: SPG_RS07460 ]
  • symbol: FolA
  • description: dihydrofolate reductase
  • length: 168
  • theoretical pI: 5.66077
  • theoretical MW: 19677.3
  • GRAVY: -0.479167

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 1.5.1.3?  ExPASy
    Dihydrofolate reductase 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH
  • TIGRFAM:
  • TheSEED  :
    • Dihydrofolate reductase (EC 1.5.1.3)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis  Dihydrofolate reductase (EC 1.5.1.3)
  • PFAM:
    DHFred (CL0387) DHFR_1; Dihydrofolate reductase (PF00186; HMM-score: 186.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003345
    • TAT(Tat/SPI): 0.00017
    • LIPO(Sec/SPII): 0.000641
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF54938 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEAYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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