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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
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ATCC 49619
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ATCC 700669
serotype 23F
BM6001
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CGSP14
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G54
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HU-OH
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Hu15
serotype 19A
Hu17
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INV104
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INV200
serotype 14
JJA
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MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
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R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS04345 [old locus tags: SPN23F08520 SPN23F_08520 ]
  • pan locus tag?: PNEUPAN001910000
  • symbol: SPN23F_RS04345
  • pan gene symbol?: rluD1
  • synonym:
  • product: RluA family pseudouridine synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS04345 [old locus tags: SPN23F08520 SPN23F_08520 ]
  • symbol: SPN23F_RS04345
  • product: RluA family pseudouridine synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 833796..834683
  • length: 888
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGAAATTAAAATTGAAACTGGTGGTCTGCGTTTGGATAAGGCTTTGTCAGATTTGTCA
    GAATTATCACGTAGTCTCGCGAATGAACAAATTAAATCAGGCCAGGTCTTGGTCAATGGT
    CAAGTCAAGAAAGCTAAATACACAGTCCAAGAGGGTGATGTCGTCACTTACCATGTGCCA
    GAACCAGAGGTATTAGAGTATGTGGCTGAGGATCTTCCGCTAGAAATAGTCTACCAAGAT
    GAGGATGTGGCTGTCGTTAACAAACCTCAGGGAATGGTTGTGCACCCGAGTGCTGGTCAT
    ACCAGTGGAACCCTAGTAAATGCCCTCATGTATCATATTAAGGACTTGTCGGGTATCAAT
    GGGGTTCTGCGTCCAGGGATTGTTCACCGTATTGATAAGGATACGTCAGGTCTTCTCATG
    ATTGCTAAAAACGATGATGCGCATCTAGTACTTGCCCAAGAACTCAAAGATAAAAAGTCT
    CTCCGCAAATATTGGGCGATTGTTCATGGAAATCTGCCTAATGATCGTGGTGTAATTGAA
    GCGCCGATTGGCCGGAGTGAAAAAGACCGTAAGAAACAGGCTGTAACTGCTAAAGGGAAG
    CCTGCAGTGACGCGTTTTCACGTCTTGGAACGCTTTGGCGATTATAGCTTAGTAGAGTTG
    CAACTGGAGACAGGGCGCACTCATCAAATCCGTGTCCACATGGCTTATATCGGCCATTCA
    GTCGCTGGTGATGAGGTCTATGGTCCTCGCAAGACTTTGAAAGGACATGGACAATTTCTT
    CATGCCAAGACTTTAGGTTTTACTCATCCGAGAACAGGTAAGACCTTGGAATTTAAAGCA
    GATATCCCAGAGATTTTTAAGGAAACCTTGGAGAGATTGAGAAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    888

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS04345 [old locus tags: SPN23F08520 SPN23F_08520 ]
  • symbol: SPN23F_RS04345
  • description: RluA family pseudouridine synthase
  • length: 295
  • theoretical pI: 9.3317
  • theoretical MW: 32868.5
  • GRAVY: -0.395593

⊟Function[edit | edit source]

  • reaction:
    EC 5.4.99.-?  ExPASy
  • ⊞TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification pseudouridine synthase, RluA family (TIGR00005; EC 5.4.99.-; HMM-score: 320.4)
    and 3 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification pseudouridine synthase Rlu family protein, TIGR01621 (TIGR01621; EC 5.4.99.-; HMM-score: 101.3)
    Genetic information processing Protein synthesis tRNA and rRNA base modification pseudouridine synthase (TIGR00093; EC 5.4.99.-; HMM-score: 26.7)
    Metabolism Energy metabolism Photosynthesis photosystem II S4 domain protein (TIGR03069; HMM-score: 15)
  • TheSEED: see SPN23F08520
  • ⊞PFAM:
    PseudoU_synth (CL0649) PseudoU_synth_2; RNA pseudouridylate synthase (PF00849; HMM-score: 124.1)
    and 2 more
    S4 (CL0492) S4; S4 domain (PF01479; HMM-score: 41.1)
    S4_2; S4 domain (PF13275; HMM-score: 13.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.998
    • Cytoplasmic Membrane Score: 0.001
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.001
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007928
    • TAT(Tat/SPI): 0.001977
    • LIPO(Sec/SPII): 0.001034
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000403199 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKKAKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTSGTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLVLAQELKDKKSLRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLVELQLETGRTHQIRVHMAYIGHSVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTLEFKADIPEIFKETLERLRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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