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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1738 [new locus tag: SP_RS08600 ]
  • pan locus tag?: PNEUPAN003148000
  • symbol: gmk
  • pan gene symbol?: gmk
  • synonym:
  • product: guanylate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1738 [new locus tag: SP_RS08600 ]
  • symbol: gmk
  • product: guanylate kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1642485..1643111
  • length: 627
  • essential: yes [1]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGGCAGACCGAGGCTTACTAATCGTTTTTTCTGGTCCTTCAGGGGTTGGAAAAGGAACG
    GTTAGAAGAGAGATTTTTGAGAGTTCTGAAAACCAATTTCAATATTCTGTATCGATGACG
    ACACGCGCACAACGTCCTGGAGAAGTGGACGGTGTTGACTATTTCTTCCGTACTCGTGAA
    GAATTTGAAGAGCTGATTCGTCAAGGACAGATGTTGGAATACGCAGAATATGTCGGTAAC
    TACTATGGAACTCCTCTGACCTATGTCAATGAAACCTTGGACAAGGGAATCGATGTTTTC
    CTTGAAATTGAAGTTCAGGGTGCTCTTCAGGTCAAGAAAAAGGTTCCAGATGCTGTCTTT
    ATCTTCCTGACACCACCAGATTTGGATGAATTGCAAGATCGCTTGGTAGGTCGTGGAACA
    GATAGTGCAGAAGTGATTGCCCAACGAATCGAAAAGGCCAAGGAAGAAATTGCCCTCATG
    CGTGAGTATGATTATGCGATTGTCAACGATCAGGTACCCCTAGCTGCTGAACGTGTCAAA
    TGTGTGATTGAAGCAGAACACTTCTGTGTGGATCGTGTCATTGGTCACTATCAGGAGATG
    TTACCAAAATCTCCAACTACCCGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    627

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1738 [new locus tag: SP_RS08600 ]
  • symbol: Gmk
  • description: guanylate kinase
  • length: 208
  • theoretical pI: 4.45392
  • theoretical MW: 23685.7
  • GRAVY: -0.336058

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.4.8?  ExPASy
    Guanylate kinase ATP + GMP = ADP + GDP
  • ⊞TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanylate kinase (TIGR03263; EC 2.7.4.8; HMM-score: 239.9)
    and 4 more
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN (TIGR02322; HMM-score: 42.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 16.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions dTMP kinase (TIGR00041; EC 2.7.4.9; HMM-score: 13)
    MJ0042 family finger-like domain (TIGR02098; HMM-score: 12.4)
  • TheSEED  :
    • Guanylate kinase (EC 2.7.4.8)
    Nucleosides and Nucleotides Purines Purine conversions  Guanylate kinase (EC 2.7.4.8)
  • ⊞PFAM:
    P-loop_NTPase (CL0023) Guanylate_kin; Guanylate kinase (PF00625; HMM-score: 173.3)
    and 7 more
    AAA_18; AAA domain (PF13238; HMM-score: 23.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 16.2)
    AAA_22; AAA domain (PF13401; HMM-score: 13.5)
    AAA_33; AAA domain (PF13671; HMM-score: 13.4)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 12.8)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 12.5)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011558
    • TAT(Tat/SPI): 0.005099
    • LIPO(Sec/SPII): 0.004885
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MADRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQRPGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALMREYDYAIVNDQVPLAAERVKCVIEAEHFCVDRVIGHYQEMLPKSPTTR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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