⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 31-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae 670-6B
locus tag: SP670_1928 [new locus tag: SP670_RS09600 ]
pan locus tag^?: PNEUPAN003375000
symbol: galK
pan gene symbol^?: galK
• synonym:
• product: galactokinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP670_1928 [new locus tag: SP670_RS09600 ]
• symbol: galK
• product: galactokinase
• replicon: chromosome
• strand: -
• coordinates: 1796596..1797774
• length: 1179
• essential: unknown

⊟Accession numbers

• Location: CP002176 (1796596..1797774) NCBI
• BioCyc: see SP670_RS09600
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1634 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGACACAACATCTTACTGCTGAAACTCTTCGCAAAGACTTTCTTGCTGTTTTTGGTCAA
  GAAGCAGACCAAACCTTCTTTTCACCAGGCCGTATTAATTTGATTGGTGAACACACAGAC
  TACAACGGTGGGCACGTTTTTCCTGCTGCTATTTCCTTAGGAACTTATGGTGCAGCTCGC
  AAGCGTGATGACCAAGTCTTGCGTTTCTACTCAGCTAACTTTGAGGACAAGGGCATAATT
  GAAGTGCCTCTCGCTGACCTCAAGTTTGAAAAAGAGCACAACTGGACCAACTATCCAAAA
  GGGGTTCTTCATTTCTTGCAAGAAGCTGGGCACGTGATTGACAAAGGTTTTGATTTTTAT
  GTTTATGGGAATATCCCAAATGGTGCTGGTTTGTCTTCTTCAGCATCCTTGGAGCTCTTG
  ACAGGGGTAGTGGCAGAGCATCTCTTTGATTTAAAACTAGAGCGTCTCGATTTGGTTAAA
  ATCGGAAAACAAACAGAAAATAACTTTATCGGAGTAAATTCTGGCATTATGGACCAATTT
  GCTATTGGTATGGGGGCTGACCAACGTGCTATTTACTTAGATACCAATACTTTAGAATAC
  GACTTGGTGCCACTTGATTTGAAGGACAATGTCGTTGTTATCATGAACACCAACAAACGC
  CGTGAATTGGCGGACTCTAAATACAATGAACGTCGTGCTGAGTGTGAAAAAGCAGTGGAA
  GAATTGCAAGTTGCCTTGGATATTCAGACCCTGGGTGAATTGGACGAGTGGGCCGTTGAC
  CAATATAGCTATTTGATTAAAGATGAAAATCGTTTGAAACGTGCTCGCCATGCTGTGCTT
  GAAAACCAACGTACCCTTAAAGCTCAAGCAGCCCTTCAAGCAGGTGATTTGGAAACATTT
  GGTCGTTTGATGAATGCGTCACACGTTTCTCTGGAGCATGATTATGAAGTAACTGGTTTG
  GAATTGGATACTCTTGTTCACACAGCTTGGGCACAAGAAGGAGTTCTCGGTGCTCGTATG
  ACAGGGGCTGGTTTTGGTGGCTGTGCCATTGCCTTGGTTCAAAAAGATACTGTTGAGGCC
  TTTAAGGAAGCTGTAGGCAAACACTACGAGGAAGTAGTTGGATACGCTCCAAGCTTCTAT
  ATCGCTGAAGTTGCAGGTGGCACTCGCGTCCTTGACTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1179
  

⊟Protein

⊟General

• locus tag: SP670_1928 [new locus tag: SP670_RS09600 ]
• symbol: GalK
• description: galactokinase
• length: 392
• theoretical pI: 4.71021
• theoretical MW: 43569.7
• GRAVY: -0.243878

⊟Function

• ⊞⊞reaction:
  EC 2.7.1.6?  ExPASy
  Galactokinase ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism Sugars galactokinase (TIGR00131; EC 2.7.1.6; HMM-score: 396.7)
  and 4 more
  Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 90.2)
  Metabolism Amino acid biosynthesis Aspartate family homoserine kinase (TIGR00191; EC 2.7.1.39; HMM-score: 17.8)
  Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 13)
  Metabolism Central intermediary metabolism Other diphosphomevalonate decarboxylase (TIGR01240; EC 4.1.1.33; HMM-score: 11)
• TheSEED  :
  • Galactokinase (EC 2.7.1.6)
  Carbohydrates Di- and oligosaccharides Lactose and Galactose Uptake and Utilization  Galactokinase (EC 2.7.1.6)
• ⊞⊞PFAM:
  S5 (CL0329) GalKase_gal_bdg; Galactokinase galactose-binding signature (PF10509; HMM-score: 76.1)
  and 2 more
  GHMP_C (CL0677) GHMP_kinases_C; GHMP kinases C terminal (PF08544; HMM-score: 60.3)
  S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 48.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9977
  • Cytoplasmic Membrane Score: 0.0005
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0016
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006995
  • TAT(Tat/SPI): 0.000946
  • LIPO(Sec/SPII): 0.001191
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ADM91980 NCBI
• UniProt:

⊟Protein sequence

• MTQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGVLHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVKIGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECEKAVEELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRARHAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLEHDYEVTGLELDTLVHTAWAQEGVLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1634 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications