⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 26-AUG-2017

⊟Summary

• organism: Streptococcus pneumoniae OXC141
locus tag: SPNOXC12810 [new locus tag: SPNOXC_RS06900 ]
pan locus tag^?: PNEUPAN002782000
symbol: SPNOXC12810
pan gene symbol^?: trxB
• synonym:
• product: putative thioredoxin reductase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNOXC12810 [new locus tag: SPNOXC_RS06900 ]
• symbol: SPNOXC12810
• product: putative thioredoxin reductase
• replicon: chromosome
• strand: -
• coordinates: 1301077..1301988
• length: 912
• essential: unknown

⊟Accession numbers

• Location: FQ312027 (1301077..1301988) NCBI
• BioCyc: see SPNOXC_RS06900
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1287 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
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  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  
  ATGTACGATACTATTATTATCGGTGCTGGACCTGCAGGGATGACTGCGGCCTTGTATGCT
  GCTCGAAGCAATCTAAAAGTAGCTTTGATTGAAGGTGGTCTGCCAGGTGGTCAGATGAAT
  AATACATCTGATATCGAAAATTACCCAGGATACGCTAATATTAGTGGACCTGAATTGGCT
  GAAAAGATGTTTGAACCACTTGAAAATCTTGGTGTTGAGCACATTTATGGTTATGTTGAA
  AATGTCGAAGACCATGGTGATTTTAAGAAAGTGATGACTGATGACCAAACATATGAAACA
  CGTACAGTTATCGTAGCAACTGGTTCTAAACACCGTCCTTTGGGAGTACCTGGAGAAGAA
  GAACTGAACAGTCGTGGTGTTTCTTACTGTGCTGTGTGTGATGGTGCTTTCTTCCGTGAC
  CAAGATTTATTGGTAGTTGGTGGTGGAGATTCAGCTGTTGAAGAAGCCCTCTTCTTGACT
  CGTTTTGCTAAGACTGTTACCATTGTTCACCGTCGTGACCAACTTCGTGCCCAAAAGGTT
  TTACAAGATCGCGCCTTTGCGAATGAAAAAATCAGCTTTATCTGGGATTCTGTAGTAAGG
  GAAATCAAGGGTGAAAACCGAGTAGAATCAGTCGTATTTGAAAATGTGAAAACAGGTCAA
  GTGACAGAACAAGTCTTCGGTGGTGTCTTTATCTATGTTGGATTGGACCCTCTTAGCGAT
  TTTGTTAAAGAATTGAATATCCAAGATCAGGCAGGATGGATTGTGACAGATAACCACATG
  AAAACTGCAGTCGACGGTATCTTTGCAGTTGGAGATGTTCGCTTGAAAGACCTTCGCCAA
  GTAACAACAGCGGTTGGAGATGGAGCTATCGCTGGTCAAGAAGCCTATAAATTCATTACA
  GAACATAGTTAA
  60
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  912
  

⊟Protein

⊟General

• locus tag: SPNOXC12810 [new locus tag: SPNOXC_RS06900 ]
• symbol: SPNOXC12810
• description: putative thioredoxin reductase
• length: 303
• theoretical pI: 4.50525
• theoretical MW: 33175.1
• GRAVY: -0.157756

⊟Function

• ⊞⊞TIGRFAM:
  Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 389.2)
  putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 322.2)
  and 46 more
  Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 241.2)
  Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 241.2)
  Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 94.9)
  dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 92.8)
  Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 69.9)
  thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 54.6)
  Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 52.6)
  Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 48.6)
  Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 46.9)
  Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 40.9)
  putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 40.6)
  mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 39.7)
  Metabolism Amino acid biosynthesis Glutamate family glutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 35.7)
  Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 35.6)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 34.1)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis enzyme (TIGR00292; HMM-score: 32)
  mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 29.2)
  mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 27.7)
  lycopene cyclase family protein (TIGR01790; HMM-score: 27.3)
  Metabolism Central intermediary metabolism Nitrogen metabolism nitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 25.4)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 22.4)
  trypanothione-disulfide reductase (TIGR01423; EC 1.8.1.12; HMM-score: 22)
  pyridine nucleotide-disulfide oxidoreductase family protein (TIGR03169; HMM-score: 21.1)
  Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 21)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 19.8)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides L-aspartate oxidase (TIGR00551; EC 1.4.3.16; HMM-score: 19.4)
  flavin-dependent oxidoreductase, MSMEG_0569 family (TIGR04046; HMM-score: 19.4)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenyl-6-methoxyphenol 4-hydroxylase (TIGR01984; EC 1.14.13.-; HMM-score: 18.6)
  Metabolism Energy metabolism TCA cycle succinate dehydrogenase, flavoprotein subunit (TIGR01816; HMM-score: 18.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02023; EC 1.3.1.-; HMM-score: 17.7)
  Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.4)
  Metabolism Energy metabolism Anaerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.4)
  Metabolism Energy metabolism Aerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.4)
  Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, B subunit (TIGR03378; EC 1.1.5.3; HMM-score: 17.2)
  squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 16)
  glutamate synthase, small subunit (TIGR01318; HMM-score: 15.3)
  Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, beta subunit family (TIGR01373; HMM-score: 15.3)
  glutamate synthase, NADH/NADPH, small subunit (TIGR01317; EC 1.4.1.-; HMM-score: 15)
  Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 15)
  fumarate reductase (quinol), flavoprotein subunit (TIGR01176; EC 1.3.5.4; HMM-score: 14.5)
  FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 14.4)
  Metabolism Energy metabolism Electron transport flavocytochrome c (TIGR01813; HMM-score: 13.3)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-galactopyranose mutase (TIGR00031; EC 5.4.99.9; HMM-score: 12.9)
  Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 12.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other phytoene desaturase (TIGR02734; EC 1.14.99.-; HMM-score: 12)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin 3B synthase CobZ (TIGR02485; HMM-score: 11.7)
• ⊞⊞TheSEED  :
  • Thioredoxin reductase (EC 1.8.1.9)
  Nucleosides and Nucleotides Pyrimidines pyrimidine conversions  Thioredoxin reductase (EC 1.8.1.9)
  and 1 more
  Sulfur Metabolism Sulfur Metabolism - no subcategory Thioredoxin-disulfide reductase  Thioredoxin reductase (EC 1.8.1.9)
• ⊞⊞PFAM:
  NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 165.4)
  and 16 more
  Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 98.2)
  Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 77.8)
  DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 44.3)
  FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 37.3)
  GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 36.2)
  FAD_binding_2; FAD binding domain (PF00890; HMM-score: 35.9)
  HI0933_like; HI0933-like protein (PF03486; HMM-score: 33.2)
  Lycopene_cycl; Lycopene cyclase protein (PF05834; HMM-score: 30.8)
  Thi4; Thi4 family (PF01946; HMM-score: 29.3)
  NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 27)
  NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 20)
  NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 19.9)
  Lys_Orn_oxgnase; L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase (PF13434; HMM-score: 18)
  FAD_binding_3; FAD binding domain (PF01494; HMM-score: 17.7)
  Trp_halogenase; Tryptophan halogenase (PF04820; HMM-score: 11.6)
  AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 10.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.123075
  • TAT(Tat/SPI): 0.022348
  • LIPO(Sec/SPII): 0.052237
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CBW32934 NCBI
• UniProt:

⊟Protein sequence

• MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSDIENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRTVIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEALFLTRFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKTGQVTEQVFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDNHMKTAVDGIFAVGDVRLKDLRQVTTAVGDGAIAGQEAYKFITEHS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1287 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications