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From PneumoWiki
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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS06890 [old locus tag: MDRSPN_01308 ]
  • pan locus tag?: PNEUPAN002972000
  • symbol: MDRSPN_RS06890
  • pan gene symbol?: murT
  • synonym:
  • product: Mur ligase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS06890 [old locus tag: MDRSPN_01308 ]
  • symbol: MDRSPN_RS06890
  • product: Mur ligase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1330884..1332227
  • length: 1344
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (1330884..1332227) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1416 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACTTAAAAACTACTTTGGGCCTTCTTGCTGGGCGTTCTTCCCACTTCATTTTAAGC
    CGTCTTGGCCGTGGAAGTACGCTCCCAGGTAAAGTCGCCCTTCAATTTGATAAAGATATT
    TTACAAAACCTAGCTAAGAACTACGAGATTGTCGTTGTCACTGGAACAAATGGAAAAACC
    CTGACAACTGCCCTCACTGTCGGCATTTTAAAAGAGGTTTATGGTCAAGTTCTAACCAAC
    CCAAGCGGTGCCAACATGATTACAGGGATTGCAACAACCTTCCTAACAGCCAAATCTTCA
    AAAACTGGGAAAAATATTGCCGTCCTCGAAATTGACGAAGCCAGTCTATCTCGTATCTGT
    GACTATATCCAGCCTAGTCTTTTTGTCATTACTAATATCTTCCGTGACCAGATGGACCGT
    TTCGGTGAAATCTATACTACCTATAACATGATATTGGAAGCCATTCGGAAAGTTCCAACT
    GCTACTGTTCTCCTTAACGGAGACAGTCCACTTTTCTACAAGCCAACTATTCCAAACCCT
    ATAGAGTATTTTGGTTTTGACTTGGAAAAAGGACCAGCCCAACTGGCTCACTACAATACC
    GAAGGGATTCTCTGTCCTGACTGCCAAGGCATCCTCAAATATGAGCATAATACCTATGCA
    AACTTGGGTGCCTATATCTGTGAAGGTTGTGGATGCAAACGTCCTGATCTCGACTATCGT
    TTGACAAAACTGGTTGAGTTGACCAACAATCGCTCTCGCTTTGTCATAGACGGCCAAGAA
    TACGGTATCCAAATCGGCGGGCTCTATAATATCTATAACGCCCTAGCTGCTGTGGCCATC
    GCCCGTTTCCTAGGTGCCGATTCGCAACTCATCAAACAGGGATTTGACAAGAGCCGTGCT
    GTCTTTGGACGCCAAGAAACCTTTCATATCGGTGACAAGGAATGTACCCTTGTCTTGATT
    AAAAATCCAGTCGGTGCAACCCAAGCTATCGAAATGATCAAACTAGCACCTTATCCATTT
    AGCCTATCTGTCCTCCTTAATGCCAACTATGCAGATGGAATTGACACTAGCTGGATCTGG
    GATGCAGACTTTGAGCAAATCACTGACATGGACATTCCTGAAATCAACGCTGGCGGTGTT
    CGTCATTCTGAAATCGCTCGTCGCCTCCGAGTGACTGGCTATCCAGCTGAGAAAATCACT
    GAAACGAGTAATCTGGAGCAAGTTCTCAAGACCATTGAGAATCAAGACTGCAAGCATGCC
    TATATTCTGGCAACTTATACTGCCATGCTGGAATTTCGTGAACTGCTGGCTAGTCGTCAG
    ATTGTTAGAAAGGAGATGAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1344

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS06890 [old locus tag: MDRSPN_01308 ]
  • symbol: MDRSPN_RS06890
  • description: Mur ligase family protein
  • length: 447
  • theoretical pI: 6.51641
  • theoretical MW: 49630.7
  • GRAVY: -0.0668904

⊟Function[edit | edit source]

  • ⊞⊞TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (TIGR01143; EC 6.3.2.10; HMM-score: 60.6)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate--L-alanine ligase (TIGR01082; EC 6.3.2.8; HMM-score: 59.6)
    and 6 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoylalanine--D-glutamate ligase (TIGR01087; EC 6.3.2.9; HMM-score: 37.8)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramyl-tripeptide synthetase (TIGR01085; HMM-score: 34.4)
    Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 21.2)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (TIGR01081; HMM-score: 19.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs bacillithiol biosynthesis cysteine-adding enzyme BshC (TIGR03998; HMM-score: 16)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid bifunctional protein FolC (TIGR01499; EC 6.3.2.-; HMM-score: 12.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞⊞PFAM:
    no clan defined MurT_C; MurT ligase C-terminal (PF08353; HMM-score: 113.2)
    and 3 more
    P-loop_NTPase (CL0023) Mur_ligase_M; Mur ligase middle domain (PF08245; HMM-score: 57.4)
    HUP (CL0039) BshC; Bacillithiol biosynthesis BshC (PF10079; HMM-score: 11.7)
    Zn_Beta_Ribbon (CL0167) TF_Zn_Ribbon; TFIIB zinc-binding (PF08271; HMM-score: 9.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.039851
    • TAT(Tat/SPI): 0.003953
    • LIPO(Sec/SPII): 0.006386
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001050235 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNLAKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKTGKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILEAIRKVPTATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNTYANLGAYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALAAVAIARFLGADSQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIKLAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVTGYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=MDRSPN_RS06890&oldid=106691"
Insert paragraph

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae MDRSPN001
  • locus tag: MDRSPN_RS06890 [old locus tag: MDRSPN_01308 ]
  • pan locus tag?: PNEUPAN002972000
  • symbol: MDRSPN_RS06890
  • pan gene symbol?: murT
  • synonym:
  • product: Mur ligase family protein

Insert paragraph

⊟Genome View[edit | edit source]

Insert paragraph

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: MDRSPN_RS06890 [old locus tag: MDRSPN_01308 ]
  • symbol: MDRSPN_RS06890
  • product: Mur ligase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1330884..1332227
  • length: 1344
  • essential: unknown

Insert paragraph

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018391 (1330884..1332227) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1416 PneumoBrowse

Insert paragraph

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACTTAAAAACTACTTTGGGCCTTCTTGCTGGGCGTTCTTCCCACTTCATTTTAAGC
    CGTCTTGGCCGTGGAAGTACGCTCCCAGGTAAAGTCGCCCTTCAATTTGATAAAGATATT
    TTACAAAACCTAGCTAAGAACTACGAGATTGTCGTTGTCACTGGAACAAATGGAAAAACC
    CTGACAACTGCCCTCACTGTCGGCATTTTAAAAGAGGTTTATGGTCAAGTTCTAACCAAC
    CCAAGCGGTGCCAACATGATTACAGGGATTGCAACAACCTTCCTAACAGCCAAATCTTCA
    AAAACTGGGAAAAATATTGCCGTCCTCGAAATTGACGAAGCCAGTCTATCTCGTATCTGT
    GACTATATCCAGCCTAGTCTTTTTGTCATTACTAATATCTTCCGTGACCAGATGGACCGT
    TTCGGTGAAATCTATACTACCTATAACATGATATTGGAAGCCATTCGGAAAGTTCCAACT
    GCTACTGTTCTCCTTAACGGAGACAGTCCACTTTTCTACAAGCCAACTATTCCAAACCCT
    ATAGAGTATTTTGGTTTTGACTTGGAAAAAGGACCAGCCCAACTGGCTCACTACAATACC
    GAAGGGATTCTCTGTCCTGACTGCCAAGGCATCCTCAAATATGAGCATAATACCTATGCA
    AACTTGGGTGCCTATATCTGTGAAGGTTGTGGATGCAAACGTCCTGATCTCGACTATCGT
    TTGACAAAACTGGTTGAGTTGACCAACAATCGCTCTCGCTTTGTCATAGACGGCCAAGAA
    TACGGTATCCAAATCGGCGGGCTCTATAATATCTATAACGCCCTAGCTGCTGTGGCCATC
    GCCCGTTTCCTAGGTGCCGATTCGCAACTCATCAAACAGGGATTTGACAAGAGCCGTGCT
    GTCTTTGGACGCCAAGAAACCTTTCATATCGGTGACAAGGAATGTACCCTTGTCTTGATT
    AAAAATCCAGTCGGTGCAACCCAAGCTATCGAAATGATCAAACTAGCACCTTATCCATTT
    AGCCTATCTGTCCTCCTTAATGCCAACTATGCAGATGGAATTGACACTAGCTGGATCTGG
    GATGCAGACTTTGAGCAAATCACTGACATGGACATTCCTGAAATCAACGCTGGCGGTGTT
    CGTCATTCTGAAATCGCTCGTCGCCTCCGAGTGACTGGCTATCCAGCTGAGAAAATCACT
    GAAACGAGTAATCTGGAGCAAGTTCTCAAGACCATTGAGAATCAAGACTGCAAGCATGCC
    TATATTCTGGCAACTTATACTGCCATGCTGGAATTTCGTGAACTGCTGGCTAGTCGTCAG
    ATTGTTAGAAAGGAGATGAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1344

Insert paragraph

This data comes from external databases and cannot be edited.

Insert paragraph

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: MDRSPN_RS06890 [old locus tag: MDRSPN_01308 ]
  • symbol: MDRSPN_RS06890
  • description: Mur ligase family protein
  • length: 447
  • theoretical pI: 6.51641
  • theoretical MW: 49630.7
  • GRAVY: -0.0668904

Insert paragraph

⊟Function[edit | edit source]

  • ⊞TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (TIGR01143; EC 6.3.2.10; HMM-score: 60.6)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate--L-alanine ligase (TIGR01082; EC 6.3.2.8; HMM-score: 59.6)
    and 6 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoylalanine--D-glutamate ligase (TIGR01087; EC 6.3.2.9; HMM-score: 37.8)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramyl-tripeptide synthetase (TIGR01085; HMM-score: 34.4)
    Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 21.2)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (TIGR01081; HMM-score: 19.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs bacillithiol biosynthesis cysteine-adding enzyme BshC (TIGR03998; HMM-score: 16)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid bifunctional protein FolC (TIGR01499; EC 6.3.2.-; HMM-score: 12.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • ⊞PFAM:
    no clan defined MurT_C; MurT ligase C-terminal (PF08353; HMM-score: 113.2)
    and 3 more
    P-loop_NTPase (CL0023) Mur_ligase_M; Mur ligase middle domain (PF08245; HMM-score: 57.4)
    HUP (CL0039) BshC; Bacillithiol biosynthesis BshC (PF10079; HMM-score: 11.7)
    Zn_Beta_Ribbon (CL0167) TF_Zn_Ribbon; TFIIB zinc-binding (PF08271; HMM-score: 9.6)

Insert paragraph

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Insert paragraph

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.039851
    • TAT(Tat/SPI): 0.003953
    • LIPO(Sec/SPII): 0.006386
  • predicted transmembrane helices (TMHMM): 0

Insert paragraph

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001050235 NCBI
  • UniProt:

Insert paragraph

⊟Protein sequence[edit | edit source]

  • MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNLAKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKTGKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILEAIRKVPTATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNTYANLGAYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALAAVAIARFLGADSQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIKLAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVTGYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN

Insert paragraph

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Insert paragraph

⊟Expression & Regulation[edit | edit source]

Insert paragraph

⊟Operon[edit | edit source]

Insert paragraph

⊟Regulation[edit | edit source]

  • regulator:

Insert paragraph

⊟Expression data[edit | edit source]

Insert paragraph

⊞Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

⊞Other Information[edit | edit source]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

Insert paragraph

⊟Relevant publications[edit | edit source]

Insert paragraph