⊟Summary[edit | edit source]

PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 31-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae JJA
locus tag: SPJ_0411 [new locus tag: SPJ_RS02090 ]
pan locus tag^?: PNEUPAN001269000
symbol: accC
pan gene symbol^?: accC
• synonym:
• product: acetyl-CoA carboxylase, biotin carboxylase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPJ_0411 [new locus tag: SPJ_RS02090 ]
• symbol: accC
• product: acetyl-CoA carboxylase, biotin carboxylase
• replicon: chromosome
• strand: +
• coordinates: 395629..396996
• length: 1368
• essential: unknown other strains

⊟Accession numbers

• Location: CP000919 (395629..396996) NCBI
• BioCyc: see SPJ_RS02090
• MicrobesOnline: 7478688 MicrobesOnline
• PneumoBrowse for strain D39V: SPV_0388 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  
  ATGTTTCGAAAAATTTTAATTGCCAATCGTGGTGAAATTGCGGTTCGTATTATCCGTGCG
  GCACGTGAATTGGGGATTGCGACGGTAGCGGTTTATTCAACTGCTGATAAGGAAGCTCTT
  CATACGCTTTTGGCAGATGAAGCAGTTTGTATTGGTCCTGGCAAGGCAACAGAGTCTTAT
  CTCAATATTAATGCAGTTCTATCAGCTGCAGTCTTGACTGAGGCAGAAGCTATTCACCCT
  GGTTTTGGATTTCTCAGTGAAAATTCCAAATTTGCGACCATGTGTGAAGAAGTAGGTATC
  AAGTTTATCGGTCCATCTGGTCATGTTATGGATATGATGGGGGATAAGATCAATGCGCGT
  GCTCAGATGATTAAAGCAGGTGTGCCTGTTATACCAGGTTCAGATGGAGAAGTGCATAAC
  TCTGAAGAAGCTTTGATTGTTGCTGAAAAAATTGGCTATCCTGTTATGCTCAAGGCTTCA
  GCAGGTGGAGGTGGTAAAGGGATTCGTAAGGTTGAAAAACCAGATGACCTCGTTTCTGCC
  TTTGAAACTGCCTCTAGTGAGGCCAAGGCCAATTATGGCAATGGTGCCATGTACATAGAA
  CGGGTTATCTATCCAGCTCGGCACATTGAGGTTCAAATCCTAGGTGATGAGCATGGACAT
  GTGATTCACTTGGGTGAACGGGATTGTTCTCTTCAAAGGAATAACCAAAAGGTTTTGGAA
  GAAAGTCCCTCGATTGCAATCGGAAAAACGCTGCGTCATGAAATAGGTGCTGCTGCTGTT
  CGAGCGGCAGAGTTTGTTGGCTATGAGAATGCAGGAACCATTGAATTTCTTCTTGATGAA
  GCAAGTAGAAATTTCTATTTCATGGAGATGAATACTCGTGTTCAGGTAGAACATCCAGTA
  ACAGAGTTTGTTTCAGGTGTTGATATCGTTAAGGAACAGATTTGCATTGCGGCAGGTCAG
  CCTTTGTCTGTTAAGCAAGAAGATATTGTCCTACGCGGTCATGCCATCGAGTGTCGTATC
  AATGCAGAAAACCCAGCCTTTAACTTTGCTCCAAGTCCAGGTAAGATTACTAATCTCTAT
  CTGCCAAGTGGTGGAGTTGGCTTGCGCGTGGATTCAGCAGTTTATCCAGGTTATACCATT
  CCGCCTTATTATGATAGTATGATTGCCAAAATCATAGTACACGGCGAAAATCGTTTTGAC
  GCCTTGATGAAAATGCAACGTGCCCTCTATGAATTAGAGATTGAAGGAGTGCAGACCAAT
  GCAGATTTCCAGCTTGATCTCATTTCAGATCGCAATGTCATTGCTGGGGATTATGATACT
  TCCTTCTTGATGGAAACCTTCTTACCTAAATATCAAGAAAAAGAATAA
  60
  120
  180
  240
  300
  360
  420
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  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1368
  

⊟Protein

⊟General

• locus tag: SPJ_0411 [new locus tag: SPJ_RS02090 ]
• symbol: AccC
• description: acetyl-CoA carboxylase, biotin carboxylase
• length: 455
• theoretical pI: 4.92007
• theoretical MW: 49608.3
• GRAVY: -0.0514286

⊟Function

• ⊞⊞reaction:
  EC 6.4.1.2?  ExPASy
  Acetyl-CoA carboxylase ATP + acetyl-CoA + HCO₃(-) = ADP + phosphate + malonyl-CoA
• ⊞⊞TIGRFAM:
  Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, biotin carboxylase subunit (TIGR00514; EC 6.3.4.14; HMM-score: 674.6)
  Metabolism Energy metabolism Glycolysis/gluconeogenesis pyruvate carboxylase (TIGR01235; EC 6.4.1.1; HMM-score: 548.4)
  and 8 more
  Metabolism Central intermediary metabolism Nitrogen metabolism urea carboxylase (TIGR02712; EC 6.3.4.6; HMM-score: 539.3)
  alpha-L-glutamate ligase, RimK family (TIGR00768; EC 6.3.2.-; HMM-score: 50.9)
  lysine biosynthesis enzyme LysX (TIGR02144; HMM-score: 50.8)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan D-alanine--D-alanine ligase (TIGR01205; EC 6.3.2.4; HMM-score: 48.3)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, large subunit (TIGR01369; EC 6.3.5.5; HMM-score: 36.3)
  Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 31.5)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylglycinamide formyltransferase 2 (TIGR01142; EC 2.1.2.-; HMM-score: 24.7)
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylamine--glycine ligase (TIGR00877; EC 6.3.4.13; HMM-score: 18.1)
• ⊞⊞TheSEED  :
  • Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)
  Fatty Acids, Lipids, and Isoprenoids Fatty acids Fatty Acid Biosynthesis FASII  Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)
  and 1 more
  Miscellaneous Miscellaneous - no subcategory EC 6.3.4.- Ligases that form carbon-nitrogen bonds  Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)
• ⊞⊞PFAM:
  ATP-grasp (CL0179) CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786; HMM-score: 241.5)
  and 7 more
  PreATP-grasp (CL0483) Biotin_carb_N; Biotin carboxylase, N-terminal domain (PF00289; HMM-score: 153.7)
  Hybrid (CL0105) Biotin_carb_C; Biotin carboxylase C-terminal domain (PF02785; HMM-score: 132.4)
  ATP-grasp (CL0179) Dala_Dala_lig_C; D-ala D-ala ligase C-terminus (PF07478; HMM-score: 49)
  ATP-grasp; ATP-grasp domain (PF02222; HMM-score: 23.8)
  RimK; RimK-like ATP-grasp domain (PF08443; HMM-score: 16)
  ATP-grasp_4; ATP-grasp domain (PF13535; HMM-score: 12.7)
  ATP-grasp_3; ATP-grasp domain (PF02655; HMM-score: 12.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• ⊞⊞PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• ⊞⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9792
  • Cytoplasmic Membrane Score: 0.0033
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0175
• ⊞⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.052372
  • TAT(Tat/SPI): 0.007584
  • LIPO(Sec/SPII): 0.005732
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: ACO19738 NCBI
• UniProt: C1CCJ0 UniProt

⊟Protein sequence

• MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKASAGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASRNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: SPJ_0401 > SPJ_0402 > SPJ_0403 > SPJ_0404 > SPJ_0405 > fabD > fabG > fabF > accB > fabZ > accC > accD > accA

⊟Regulation

• ⊞⊞regulator: FabT* (repression) regulon

  FabT*

  (TF)

  important in Fatty acid biosynthesis; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise

⊟Expression data

• PneumoExpress for strain D39V: SPV_0388 PneumoExpress

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications