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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-NOV-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_00122 [new locus tag: A66_RS00605 ]
  • pan locus tag?: PNEUPAN000067000
  • symbol: A66_00122
  • pan gene symbol?: rtgB
  • synonym:
  • product: HlyD family secretion protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_00122 [new locus tag: A66_RS00605 ]
  • symbol: A66_00122
  • product: HlyD family secretion protein
  • replicon: chromosome
  • strand: +
  • coordinates: 115937..117289
  • length: 1353
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: LN847353 (115937..117289) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0115 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAAATTATATAATAAATCAGAATTACGTTATTCTCGCATTTTCTTTGATAAGAGACCA
    CCAGCTTTTGCGTTTATTCTCATTATTTCAACTGCTATTATCTTAAGCGGTGCATTGGTT
    GGCGCAGCTTATATACCCAAAAACTATATTGTAAAAGCGAATGGAAATTCAGTCATAACA
    GGTACAGAGTTCCTATCAGCAATTAGTTCAGGGAAGGTAGTTACTTTACATAAGTCAGAA
    GGAGATATGGTAAATGCTGGAGATGTCATTATTTCGTTATCAAGTGGACAAGAAGGTTTA
    CAAGCGAGCTCTTTAAATAAACAATTGGTGAAGTTACGTGCAAAAGAAGCTATCTTTCAA
    AAATTTGAACAATCATTAAATGAGAAATACAACCGTATGTCTAATTCTGGTGAAGAACAG
    GAATATTATGGGAAAGTTGAATACTACCTATCTCAGTTAAATTCGGAAAATTATAATAAT
    GGTACCCAGTATTCAAAGATTCAGGAAGAATATACGAAGTTGAATAAAATAACAGCTGAA
    AGAAATCAGTTAGATGCCGACTTGCAAACTCTACAAAATGAATTGATTCAACTTCAACAG
    CAAGGAGACTCCCCTTCCTTATCAGATACGACATCAGCTGATGATAAAGCTAAGTTAGAA
    ACTAAGATATTAGAAATAACAACAAAAATCGAAGCATTAAAAACAAATATTACTTCTAAG
    AATAGCGAGATTGATAGTCAACAAAGCAATATTAAAGATATGAACCGTACCTATAATGAT
    CCAACTTCTCAGGCTTATAATATTTATGCTCAATTAGTTAGTGAGTTAGGTACTGCTCGT
    TCAAACAACAATAAAAGTATTACAGAGCTTGAGGCTAATCTTGGAGTGGCAACAGGTCAA
    GATAAAGCTCATAGTATATTAGCGCCAAATGAAGGTACTCTGCATTATTTGGTACCTTTG
    AAACAAGGAATGTCTATTCAGCAGGGGCAAACGATAGCAGAAGTTTCAGGGAAAGAAAAA
    GGTTACTATGTAGAAGCTTTTGTACTTGCGAGTGATATTTCTCGTGTCTCAAAAGGAGCA
    AAAGTTGATGTTGCTATTACTGGTGTAAATAGTCAAAAATATGGAACACTAAAGGGACAA
    GTCAGACAGATTGATTCAGGAACAATTTCCCAAGAAACGAAAGAGGGGAATATTAGCCTC
    TATAAAGTCATGATAGAATTAGAAACCTTAACTCTAAAACATGGAAGTGAGACAGTCGTC
    CTCCAAAAGGATATGCCAGTTGAAGTGCGGATTGTCTATGATAAAGAAACCTATCTTGAT
    TGGATTTTGGAAATGTTAAGTTTCAAGCAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1353

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_00122 [new locus tag: A66_RS00605 ]
  • symbol: A66_00122
  • description: HlyD family secretion protein
  • length: 450
  • theoretical pI: 5.60126
  • theoretical MW: 49996
  • GRAVY: -0.436667

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 124)
    and 12 more
    Metabolism Transport and binding proteins Other bacteriocin secretion accessory protein (TIGR01000; HMM-score: 82)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system secretion protein (TIGR03794; HMM-score: 41.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system secretion protein (TIGR03794; HMM-score: 41.5)
    Metabolism Transport and binding proteins Unknown substrate efflux transporter, RND family, MFP subunit (TIGR01730; HMM-score: 35.2)
    Metabolism Transport and binding proteins Other efflux pump membrane protein (TIGR00998; HMM-score: 32.1)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 23.5)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 23.5)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 22.7)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 22.7)
    ABC exporter membrane fusion protein, DevB family (TIGR02971; HMM-score: 20.5)
    SH3 domain protein (TIGR04211; HMM-score: 12.2)
    helix-rich protein (TIGR04523; HMM-score: 6.6)
  • TheSEED: data available for D39
  • PFAM:
    Hybrid (CL0105) HlyD_3; HlyD family secretion protein (PF13437; HMM-score: 56.5)
    and 15 more
    Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 34.1)
    Biotin_lipoyl; Biotin-requiring enzyme (PF00364; HMM-score: 23.1)
    HlyD_D23; Barrel-sandwich domain of CusB or HlyD membrane-fusion (PF16576; HMM-score: 21.9)
    QRPTase_N; Quinolinate phosphoribosyl transferase, N-terminal domain (PF02749; HMM-score: 19.8)
    no clan defined PilJ; Type IV pili methyl-accepting chemotaxis transducer N-term (PF13675; HMM-score: 19.4)
    ERM_helical; Ezrin/radixin/moesin, alpha-helical domain (PF20492; HMM-score: 17.7)
    Hybrid (CL0105) CusB_dom_1; Cation efflux system protein CusB domain 1 (PF00529; HMM-score: 16.9)
    no clan defined SOK; Protein SOSEKI, plant (PF06136; HMM-score: 12)
    SlyX; SlyX (PF04102; HMM-score: 11.8)
    DUF5713; Family of unknown function (DUF5713) (PF18977; HMM-score: 10.4)
    Nup54; Nucleoporin complex subunit 54 (PF13874; HMM-score: 9.9)
    EAD9; Effector-associated domain 9 (PF19962; HMM-score: 8.8)
    Spc24; Spc24 subunit of Ndc80 (PF08286; HMM-score: 8.1)
    OmpH; Outer membrane protein (OmpH-like) (PF03938; HMM-score: 8)
    DUF4407; Domain of unknown function (DUF4407) (PF14362; HMM-score: 7.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0006
    • Cytoplasmic Membrane Score: 0.9027
    • Cell wall & surface Score: 0.0017
    • Extracellular Score: 0.0951
  • SignalP: Signal peptide SP(Sec/SPI) length 42 aa
    • SP(Sec/SPI): 0.483109
    • TAT(Tat/SPI): 0.004276
    • LIPO(Sec/SPII): 0.039245
    • Cleavage Site: CS pos: 42-43. VGA-AY. Pr: 0.3696
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CRI60833 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLYNKSELRYSRIFFDKRPPAFAFILIISTAIILSGALVGAAYIPKNYIVKANGNSVITGTEFLSAISSGKVVTLHKSEGDMVNAGDVIISLSSGQEGLQASSLNKQLVKLRAKEAIFQKFEQSLNEKYNRMSNSGEEQEYYGKVEYYLSQLNSENYNNGTQYSKIQEEYTKLNKITAERNQLDADLQTLQNELIQLQQQGDSPSLSDTTSADDKAKLETKILEITTKIEALKTNITSKNSEIDSQQSNIKDMNRTYNDPTSQAYNIYAQLVSELGTARSNNNKSITELEANLGVATGQDKAHSILAPNEGTLHYLVPLKQGMSIQQGQTIAEVSGKEKGYYVEAFVLASDISRVSKGAKVDVAITGVNSQKYGTLKGQVRQIDSGTISQETKEGNISLYKVMIELETLTLKHGSETVVLQKDMPVEVRIVYDKETYLDWILEMLSFKQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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