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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 19-NOV-2015
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae A66
- locus tag: A66_00287 [new locus tag: A66_RS01460 ]
- pan locus tag?: PNEUPAN001028000
- symbol: A66_00287
- pan gene symbol?: sulA
- synonym: folP
- product: Dihydropteroate synthase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: A66_00287 [new locus tag: A66_RS01460 ]
- symbol: A66_00287
- product: Dihydropteroate synthase
- replicon: chromosome
- strand: +
- coordinates: 268896..269870
- length: 975
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: LN847353 (268896..269870) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0269 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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961ATGATGAAAATCCTTGAGGGAGTGACCGATATGTCAAGTAAAGCCAATCATGCAAAGACA
GTTATTTGCGGAATTATCAATGTAACCCCAGACTCCTTTTCGGACGGTGGTCAATTTTTT
GCTCTTGAGCAGGCACTCCAGCAGGCTCGTAAATTGATAGCAGAAGGAGCCAGTATGCTC
GATATCGGCGGAGAATCGACTCGGCCGGGCAGTAGCTATGTTGAGATAGAAGAGGAAATC
CAGCGTGTTGTTCCAGTGATCAAAGCGATTCGCAAGGAAAGTGATGTCCTCATCTCTATT
GATACTTGGAAGAGTCAAGTAGCAGAGGCTGCTTTGGCTGCTGGTGCCGATCTAGTCAAT
GATATCACTGGTCTTATGGGTGATGAGAAAATGGCTCATGTGGTAGCTGAAGCGAGAGCG
AAAGTGGTCATCATGTTTAACCCAGTTATGGCTCGACCTCAGCATCCTAGTTCGCTTATC
TTCCCTCATTTTGGTTTTGGTCAAACCTTTACAGAAAAAGAGTTAGCTGACTTTGAAACA
TTGCCAATCGAAGACTTGATGGTGGCTTTCTTTGAACGAGCACTAGCGAGAGCGGCAGAA
GCTGGTATTGCACCAGAAAATATCCTGTTGGATCCAGGAATTGGCTTTGGTCTGACCAAG
AAAGAAAATCTGCTTCTTTTACGGGACCTGGATAAACTACATCAGAAAGGCTATCCAATC
TTTCTCGGAGTTTCGCGCAAGCGATTTGTCATCAATATCCTAGAGGAGAATGGTTTTGAA
GTCAATCCTGAGACAGAGCTTGGTTTCCGCAATCGGGACACGGCTTCGGCTCATGTAACC
AGTATCGCTGCGAGACAGGGTGTAGAAGTGGTGCGCGTGCATGACGTAGCTAGTCACAGG
ATGGCAGTTGAAATTGCCTCTACTATTCGTCTGGCTGATGAAGCGGAAAATTTAGATTTA
AAACAATATAAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: A66_00287 [new locus tag: A66_RS01460 ]
- symbol: A66_00287
- description: Dihydropteroate synthase
- length: 324
- theoretical pI: 4.93956
- theoretical MW: 35525.5
- GRAVY: -0.012037
⊟Function[edit | edit source]
- reaction: EC 2.5.1.15? ExPASyDihydropteroate synthase 6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid dihydropteroate synthase (TIGR01496; EC 2.5.1.15; HMM-score: 269.7)and 1 moreUnknown function General dihydropteroate synthase-related protein (TIGR00284; HMM-score: 13.6)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: TIM_barrel (CL0036) Pterin_bind; Pterin binding enzyme (PF00809; HMM-score: 318.9)and 1 moreSGNH_hydrolase (CL0264) Lipase_GDSL_2; GDSL-like Lipase/Acylhydrolase family (PF13472; HMM-score: 13.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9958
- Cytoplasmic Membrane Score: 0.0012
- Cell wall & surface Score: 0
- Extracellular Score: 0.0029
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.00979
- TAT(Tat/SPI): 0.000352
- LIPO(Sec/SPII): 0.00298
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: CRI60998 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMAHVVAEARAKVVIMFNPVMARPQHPSSLIFPHFGFGQTFTEKELADFETLPIEDLMVAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASTIRLADEAENLDLKQYK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0269 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
H G Vinnicombe, J P Derrick
Dihydropteroate synthase from Streptococcus pneumoniae: characterization of substrate binding order and sulfonamide inhibition.
Biochem Biophys Res Commun: 1999, 258(3);752-7
[PubMed:10329458] [WorldCat.org] [DOI] (P p)