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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-NOV-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_00345 [new locus tag: A66_RS01735 ]
  • pan locus tag?: PNEUPAN001154000
  • symbol: A66_00345
  • pan gene symbol?: cap3B
  • synonym:
  • product: Hyaluronan synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_00345 [new locus tag: A66_RS01735 ]
  • symbol: A66_00345
  • product: Hyaluronan synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 322127..323380
  • length: 1254
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: LN847353 (322127..323380) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGTATACATTTATTTTAATGTTGTTGGATTTTTTTCAGAATCATGATTTTCATTTCTTT
    ATGTTGTTTTTTGTCTTTATTCTTATTCGTTGGGCGGTTATATATTTTCATGCTGTCAGA
    TATAAGTCCTACAGTTGTAGTGTAAGTGATGAGAAGTTATTTAGTTCTGTAATTATCCCT
    GTCGTGGATGAACCACTTAATCTTTTTGAAAGTGTACTGAATAGAATTTCCAGACATAAA
    CCATCCGAAATTATTGTGGTTATTAACGGCCCAAAAAACGAGAGACTTGTAAAACTTTGT
    CATGATTTTAATGAAAAATTAGAAAATAATATGACTCCAATTCAATGTTATTACACTCCT
    GTTCCTGGCAAGAGAAATGCTATCCGCGTTGGGCTGGAGCATGTGGATTCGCAGAGTGAT
    ATTACAGTTCTAGTAGATAGTGATACAGTATGGACGCCTAGAACCTTGAGTGAGTTGCTG
    AAGCCTTTTGTTTGCGATAAAAAAATAGGTGGGGTAACGACAAGACAAAAAATTCTTGAC
    CCTGAGCGTAATCTCGTGACAATGTTTGCTAACTTGTTAGAGGAAATTAGGGCAGAAGGA
    ACTATGAAAGCAATGAGTGTGACTGGTAAAGTAGGGTGCTTACCTGGTCGAACAATTGCT
    TTTAGAACAGAGATTCTCAGAGAGTGTATACATGAGTTTATGAATGAGACTTTCATGGGA
    TTTCATAAGGAAGTTTCTGATGATAGAAGTCTTACAAATTTGACTTTAAAAAAAGGCTAT
    AAAACTGTTATGCAGGATACTTCTGTTGTGTATACAGATGCTCCTACAAGTTGGAAAAAG
    TTCATTAGACAGCAACTAAGGTGGGCAGAAGGTTCTCAGTATAACAATCTAAAGATGACT
    CCTTGGATGATTAGAAATGCCCCTCTTATGTTTTTTATTTATTTTACAGATATGATTTTA
    CCTATGCTACTTATTAGCTTTGGTGTGAATATATTCCTGTTGAAAATATTAAATATAACT
    ACAATTGTTTATACAGCTTCATGGTGGGAAATTATTTTATATGTTCTTTTGGGAATGATT
    TTTAGCTTTGGAGGAAGAAACTTTAAAGCTATGTCTAGAATGAAGTGGTATTATGTATTT
    CTTATTCCTGTTTTTATAATCGTTTTGAGTATAATTATGTGCCCTATTAGGCTATTAGGA
    CTTATGAGATGTTCTGATGATTTAGGGTGGGGAACTAGGAATTTAACAGAGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1254

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_00345 [new locus tag: A66_RS01735 ]
  • symbol: A66_00345
  • description: Hyaluronan synthase
  • length: 417
  • theoretical pI: 8.82934
  • theoretical MW: 48617.1
  • GRAVY: 0.195444

⊟Function[edit | edit source]

  • reaction:
    EC 2.4.1.212?  ExPASy
    Hyaluronan synthase UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
  • TIGRFAM:
    chitooligosaccharide synthase NodC (TIGR04242; EC 2.4.1.-; HMM-score: 73.7)
    and 8 more
    poly-beta-1,6 N-acetyl-D-glucosamine synthase (TIGR03937; EC 2.4.1.-; HMM-score: 53)
    hopanoid biosynthesis associated glycosyl transferase protein HpnI (TIGR03472; HMM-score: 30.2)
    molybdenum cofactor cytidylyltransferase (TIGR03310; EC 2.7.7.76; HMM-score: 16.2)
    cellulose synthase catalytic subunit (UDP-forming) (TIGR03030; EC 2.4.1.12; HMM-score: 15.8)
    glycosyltransferase, TIGR04182 family (TIGR04182; HMM-score: 14.4)
    Unknown function Enzymes of unknown specificity transferase 2, rSAM/selenodomain-associated (TIGR04283; EC 2.-.-.-; HMM-score: 12.5)
    Cellular processes Cellular processes Adaptations to atypical conditions phage shock protein C (TIGR02978; HMM-score: 12.4)
    mycofactocin system glycosyltransferase (TIGR03965; HMM-score: 10.3)
  • TheSEED:
  • PFAM:
    GT-A (CL0110) Glyco_tranf_2_3; Glycosyltransferase like family 2 (PF13641; HMM-score: 93.6)
    and 7 more
    Glyco_transf_21; Glycosyl transferase family 21 (PF13506; HMM-score: 55.8)
    Glyco_trans_2_3; Glycosyl transferase family group 2 (PF13632; HMM-score: 54.3)
    Chitin_synth_2; Chitin synthase (PF03142; HMM-score: 43.5)
    Glycos_transf_2; Glycosyl transferase family 2 (PF00535; HMM-score: 42.7)
    NTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 15.2)
    NTP_transferase; Nucleotidyl transferase (PF00483; HMM-score: 12.5)
    Osmo_MPGsynth; Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) (PF09488; HMM-score: 10.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.9994
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0005
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002519
    • TAT(Tat/SPI): 0.000212
    • LIPO(Sec/SPII): 0.000648
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CRI61056 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYTFILMLLDFFQNHDFHFFMLFFVFILIRWAVIYFHAVRYKSYSCSVSDEKLFSSVIIPVVDEPLNLFESVLNRISRHKPSEIIVVINGPKNERLVKLCHDFNEKLENNMTPIQCYYTPVPGKRNAIRVGLEHVDSQSDITVLVDSDTVWTPRTLSELLKPFVCDKKIGGVTTRQKILDPERNLVTMFANLLEEIRAEGTMKAMSVTGKVGCLPGRTIAFRTEILRECIHEFMNETFMGFHKEVSDDRSLTNLTLKKGYKTVMQDTSVVYTDAPTSWKKFIRQQLRWAEGSQYNNLKMTPWMIRNAPLMFFIYFTDMILPMLLISFGVNIFLLKILNITTIVYTASWWEIILYVLLGMIFSFGGRNFKAMSRMKWYYVFLIPVFIIVLSIIMCPIRLLGLMRCSDDLGWGTRNLTE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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