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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-NOV-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_00648 [new locus tag: A66_RS03230 ]
  • pan locus tag?: PNEUPAN001661000
  • symbol: A66_00648
  • pan gene symbol?: lctO
  • synonym:
  • product: Lactate 2-monooxygenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_00648 [new locus tag: A66_RS03230 ]
  • symbol: A66_00648
  • product: Lactate 2-monooxygenase
  • replicon: chromosome
  • strand: +
  • coordinates: 626900..627679
  • length: 780
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: LN847353 (626900..627679) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0621 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGCACCTGTTGCGGCTCATAAATTGGCAAATGAACAGGGGGAAGTGGCGACTGCGCGT
    GGTGTGCATGAGTTTGGTTCTCTTTATACAACCAGTTCTTACTCTACTGTTGACCTTCCA
    GAGATTTCTGAAGCCCTTCAAGGGACACCTCATTGGTTTCAATTTTACTTTAGTAAGGAT
    GACGGTATCAACCGCCACATCATGGACCGTGTGAAGGCTGAAGGTTATAAAGCGATTGTC
    TTGACGGCAGATGCTACTGTAGGGGGGAATCGTGAAGTGGATAAGCGTAATGGTTTTGTC
    TTCCCAGTTGGCATGCCGATTGTTGAAGAATACCTGCCAGAAGGTGCTGGTAAATCAATG
    GACTTTGTTTACAAATCAGCTAAACAACGCTTGTCTCCACGCGATGTAGAATTTATCGCT
    GAATACTCTGGTCTTCCTGTGTATGTCAAGGGACCACAATGCCGTGAGGACGTTGAACGT
    TCGCTTGCTGCAGGAGCTTCTGGTATCTGGGTAACCAACCACGGTGGTCGTCAAATCGAC
    GGTGGACCAGCTGCCTTTGACTCGCTTCAAGAAGTGGCAGAAGCAGTTGATAGACGTGTG
    CCGATTGTCTTTGACTCTGGTGTTCGTCGTGGTCAACACGTCTTTAAAGCCTTGGCTTCA
    GGAGCAGACCTGGTAGCTATTGGTCGCCCTGTTATTTATGGCTTGGCTCTCGGTGGTAGT
    GTCGGTGTGCGTCAAGTCTTTGAACACAGTTATGCAATTGTCTGGAGCTCAGACCATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_00648 [new locus tag: A66_RS03230 ]
  • symbol: A66_00648
  • description: Lactate 2-monooxygenase
  • length: 259
  • theoretical pI: 6.09523
  • theoretical MW: 28087.4
  • GRAVY: -0.166795

⊟Function[edit | edit source]

  • reaction:
    EC 1.13.12.4?  ExPASy
    Lactate 2-monooxygenase (S)-lactate + O2 = acetate + CO2 + H2O
  • TIGRFAM:
    Metabolism Energy metabolism Other L-lactate oxidase (TIGR02708; EC 1.1.3.-; HMM-score: 527.8)
    and 5 more
    heme/flavin dehydrogenase, mycofactocin system (TIGR03966; EC 1.-.-.-; HMM-score: 116.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other isopentenyl-diphosphate delta-isomerase, type 2 (TIGR02151; EC 5.3.3.2; HMM-score: 20.7)
    Unknown function General IMP dehydrogenase family protein (TIGR01304; HMM-score: 18.8)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 15.7)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 15)
  • TheSEED: data available for D39, TIGR4
  • PFAM:
    TIM_barrel (CL0036) FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 264.7)
    and 6 more
    IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 23.2)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 16.5)
    DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 14.1)
    Glu_synthase; Conserved region in glutamate synthase (PF01645; HMM-score: 13.8)
    ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 13)
    NMO; Nitronate monooxygenase (PF03060; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.013149
    • TAT(Tat/SPI): 0.001317
    • LIPO(Sec/SPII): 0.001661
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CRI61359 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEGYKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEHSYAIVWSSDH

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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