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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS00350 [old locus tag: A66_00067 ]
  • pan locus tag?: PNEUPAN000704000
  • symbol: strH
  • pan gene symbol?: strH
  • synonym:
  • product: LPXTG-anchored beta-N-acetylhexosaminidase StrH

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS00350 [old locus tag: A66_00067 ]
  • symbol: strH
  • product: LPXTG-anchored beta-N-acetylhexosaminidase StrH
  • replicon: chromosome
  • strand: -
  • coordinates: 63233..67162
  • length: 3930
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (63233..67162) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0063 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    ATGAAACATGAAAAACAACAGCGTTTTTCTATTCGTAAATACGCTGTAGGAACAGCTTCT
    GTTCTAATTGGATTTGCCTTCCAAGCACAGACTGTTGCAGCCGATGGAGTTACTCCTACT
    ACTACAGAAAACCAACCGACCATCCATACGGTTTCTGATTCCCCTCAATCATCCGAAAAT
    CGGACTGAGGAAACACCTAAAGCAGTGCTTCAACCAGAAGCTCCAAAAACTGTAGAAACA
    GAAACTCCAGCTACTGATAAGGTAGCTAGTCTTCCAAAAACAGAAGAAAAACCACAAGAG
    GAAGTTAGTTCAACTCCTAGTGATAAAGCAGAAGTGGTAACTCCAACTTCTGCTGAAAAA
    GAAACTGCTAATAAAAAGGCAGAAGAAGCTAGCCCTAAAAAGGAAGAAGCGAAAGAGGCT
    GATTCTAAAGAGTCAAATACAGACAAGGATAAACCAGCTAAAAAAGATGAAGCGAAAGCA
    GAGGCTGACAAACCGGAAACAGAGGCAGGAAAGGAACGTGCTGCAACTGTAAATGAAAAA
    CTAGCGAAAAAGAAAATTGTTTCCATTGATGCTGGACGTAAATATTTCTCACCAGAACAG
    CTCAAGGAAATCATCGATAAAGCGAAACATTATGGCTACACTGATTTACACCTATTAGTC
    GGAAATGATGGACTCCGTTTCATGTTGGACGATATGAGCATCACAGCTAACGGCAAGACC
    TATGCCAGTGACGATGTCAAACGCGCCATTGAAAAAGGTACAAATGATTATTACAACGAT
    CCAAACGGCAATCACTTAACAGAAAGTCAAATGACAGATCTGATTAACTATGCCAAAGAT
    AAAGGTATCGGTCTCATTCCGACAGTAAATAGTCCTGGACACATGGATGCGATTCTCAAT
    GCCATGAAAGAATTGGGAATCCAAAACCCTAACTTTAGCTATTTTGGGAAGAAATCAGCC
    CGTACTGTCGATCTTGACAACGAACAAGCTGTCGCTTTTACAAAAGCCCTTATCGACAAG
    TATGCTGCTTATTTCGCGAAAAAGACTGAAATCTTCAACATCGGACTTGATGAATATGCC
    AATGATGCGACAGATGCTAAAGGTTGGAGTGTGCTTCAAGCTGATAAATACTATCCAAAC
    GAAGGCTACCCTGTAAAAGGCTATGAAAAATTTATTGCCTACGCCAATGACCTCGCTCGT
    ATTGTAAAATCGCACGGTCTCAAACCAATGGCCTTTAACGACGGTATCTACTACAATAGC
    GACACAAGCTTTGGTAGTTTTGACAAAGACATCATCGTTTCTATGTGGACTGGTGGTTGG
    GGAGGCTACGATGTCGCTTCTTCTAAACTACTAGCTGAAAAAGGTCACCAAATCCTTAAT
    ACCAATGATGCTTGGTACTACGTTCTTGGACGAAACGCTGATGGCCAAGGCTGGTACAAT
    CTCGATCAGGGGCTCAATGGTATTAAAAACACACCAATCACTTCTGTACCAAAAACAGAA
    GGAGCTGATATCCCAATCATCGGTGGTATGGTAGCTGCTTGGGCTGACACTCCATCTGCA
    CGTTATTCACCATCACACCTCTTCAAACTCATGCGTCATTTTGCAAATGCCAACGCTGAA
    TACTTCGCAGCTGATTATGAATCTGCAGAGCAAGCACTTAACGAGGTACCAAAAGACCTG
    AACCGTTATACTGCAGAAAGCGTCGCGGCCGTAAAAGAAGCTGAAAAAGCTATCCGCTCT
    CTCGATAGCAACCTTAGCCGTGCCCAACAAGATACTATTGAACAAGCCATTGCTAAACTT
    CAAGAAACTGTCAACAACTTGACCCTCACGCCTGAAGCTCAAAAAGAAGAAGAAGCTAAA
    CGTGAGGTTGAAAAACTTGCCAAAAACAAGGTAATCTCAATCGATGCTGGACGCAAATAC
    TTTACTCTGGACCAGCTCAAACGCATCGTAGACAAGGCCAGTGAGCTCGGATATTCTGAT
    GTCCATCTCCTTCTAGGAAATGACGGACTTCGCTTTCTACTCAATGATATGACCATTACT
    GCCAACGGAAAAACCTATGCTAGTGATGACGTTAAAAAAGCTATTATCGAAGGAACTAAA
    GCTTACTACGACGATCCAAACGGTACTGCACTAACACAGGCAGAAGTGACAGAGCTAATT
    GAATACGCTAAATCTAAGGACATTGGTCTCATCCCAGCTATTAACAGTCCAGGTCACATG
    GATGCTATGCTGGTTGCCATGGAAAAATTAGGTATTAAAAATCCTCAAGCCCACTTTGAT
    AAAGTTTCAAAAACAACTATGGACTTGAAAAACGAAGAAGCGATGAACTTTGTAAAAGCC
    CTCATCGGTAAATACATGGACTTCTTTGCAGGTAAAACAAAGATTTTCAACTTTGGTACT
    GACGAATACGCCAACGATGCGACTAGTGCCCAAGGCTGGTACTACCTCAAGTGGTATCAA
    CTCTATGGCAAATTTGCCGAATATGCCAACACCCTCGCAGCTATGGCCAAAGAAAGAGGG
    CTTCAACCAATGGCCTTCAACGATGGCTTCTACTATGAAGACAAGGACGATGTTCAGTTT
    GACAAAGATGTCTTGATTTCTTACTGGTCTAAAGGCTGGTGGGGATATAACCTCGCATCA
    CCTCAATACCTAGCAAGCAAAGGCTATAAATTCTTGAATACCAACGGTGACTGGTATTAT
    GTTATAGGCAATCACAAACAAGATGAAGCTTACCCTCTTTCAAAAGCAGTTGAAAATTCT
    GGTAAAGTTCCATTCAATCAACTAGCTTCTACCAAATATCCTGAAGTAGATCTTCCAACA
    GTCGGAAGTATGCTTTCAATCTGGGCAGATAGACCAAGCGCTGAATACAAGGAAGAGGAA
    ATCTTTGAACTCATGACTGCCTTTGCAGACCACAACAAAGACTACTTCCGTGCTAATTAT
    AATGCTCTCCGCGAAGAATTAGCTAAAATTCCTACAAACTTAGAAGGATATAGTAAAGAA
    AGTCTTGAGGCCCTTGACGCAGCTAAAACAGCTCTAAATTACAACCTCAACCGTAATAAA
    CAAGCTGAGCTTGACACACTTGTAGCCAACCTAAAAGCCGCTCTTCAAGGCCTCAAACCA
    GCTGCAACTCATTCAGGAAGCCTGGATGAAAATGAAGTGGCTGCCAATGTTGAAACCAGA
    CCAGAACTCATCACAAGAACTGAAGAAATTCCATTTGAAGTTATCAAGAAAGAAAATCCT
    AACCTCCCAGCTGGTCAGGAAAATATTATCACAGCAGGAGTCAAAGGTGAACGAACTCAT
    TACATCTCTGTACTCACTGAAAATGGAAAAACAACAGAAACAGTCCTTGATAGCCAGGTA
    ACCAAAGAAGTTATAAACCAAGTGGTTGAAGTTGGCGCTCCTGTAACTCACAAGGGTGAT
    GAAAGTGGTCTTGCACCAACTACTGAGGTAAAACCTAGACTGGATATCCAAAAAGAAGAA
    ATTCCATTTACCACAGTGACTCGTGAAAATCCACTCTTACTCAAAGGAAAAACACAAGTC
    ATTACTAAGGGCGTCAATGGACATCGTAGCAACTTCTACTCTGTGAGCACTTCTGCCGAT
    GGTAAGGAAGTGAAAACACTTGTAAATAGTGTCGTAGCACAGGAAGCCGTTACTCAAATA
    GTCGAAGTCGGAACTATGGTAACACATGTAGGCGATGAAAACGGACAAGCCGCTATTGCT
    GAAGAAAAACCAAAACTAGAAATCCCAAGCCAACCAGCTCCATCAACTGCTCCCGCTGAG
    GAAAGCAAAGCTCTTCCTCAAGATCCAGCTCCTGTGGTAACAGAGAAAAAACTTCCTGAA
    ACAGGAACTCACGATTCTGCAGGACTAGTAGTCGCAGGACTCATGTCCACACTAGCAGCC
    TATGGACTCACTAAAAGAAAAGAAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3780
    3840
    3900
    3930

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS00350 [old locus tag: A66_00067 ]
  • symbol: StrH
  • description: LPXTG-anchored beta-N-acetylhexosaminidase StrH
  • length: 1309
  • theoretical pI: 4.92925
  • theoretical MW: 144308
  • GRAVY: -0.576776

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.1.52?  ExPASy
    Beta-N-acetylhexosaminidase Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 49)
    and 7 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification rRNA large subunit m3Psi methyltransferase RlmH (TIGR00246; EC 2.1.1.177; HMM-score: 23.8)
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 22.5)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 14.5)
    undecaprenyl-phosphate glucose phosphotransferase (TIGR03023; EC 2.7.8.-; HMM-score: 14.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin heme b synthase (TIGR04545; EC 1.3.99.-; HMM-score: 12.8)
    CRISPR type II-A/NMEMI-associated protein Csn2 (TIGR01866; HMM-score: 11.2)
    Metabolism Energy metabolism Photosynthesis photosystem II protein PsbQ (TIGR03042; HMM-score: 6.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Glyco_hydro_tim (CL0058) Glyco_hydro_20; Glycosyl hydrolase family 20, catalytic domain (PF00728; HMM-score: 173.3)
    and 9 more
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 100.3)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 39.4)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 28.4)
    HemX; HemX, putative uroporphyrinogen-III C-methyltransferase (PF04375; HMM-score: 17.1)
    DUF6437; Family of unknown function (DUF6437) (PF20031; HMM-score: 16)
    PSI_PsaF; Photosystem I reaction centre subunit III (PF02507; HMM-score: 13.5)
    Baculo_PEP_C; Baculovirus polyhedron envelope protein, PEP, C terminus (PF04513; HMM-score: 13.2)
    SPOUT (CL0098) SPOUT_MTase; Predicted SPOUT methyltransferase (PF02590; HMM-score: 11)
    no clan defined SLC12; Solute carrier family 12 (PF03522; HMM-score: 5.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 34 aa
    • SP(Sec/SPI): 0.959154
    • TAT(Tat/SPI): 0.022963
    • LIPO(Sec/SPII): 0.006131
    • Cleavage Site: CS pos: 34-35. VAA-DG. Pr: 0.5577
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_053039417 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKHEKQQRFSIRKYAVGTASVLIGFAFQAQTVAADGVTPTTTENQPTIHTVSDSPQSSENRTEETPKAVLQPEAPKTVETETPATDKVASLPKTEEKPQEEVSSTPSDKAEVVTPTSAEKETANKKAEEASPKKEEAKEADSKESNTDKDKPAKKDEAKAEADKPETEAGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTDLHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYNDPNGNHLTESQMTDLINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKKSARTVDLDNEQAVAFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYEKFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVASSKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIPIIGGMVAAWADTPSARYSPSHLFKLMRHFANANAEYFAADYESAEQALNEVPKDLNRYTAESVAAVKEAEKAIRSLDSNLSRAQQDTIEQAIAKLQETVNNLTLTPEAQKEEEAKREVEKLAKNKVISIDAGRKYFTLDQLKRIVDKASELGYSDVHLLLGNDGLRFLLNDMTITANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSPGHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKIFNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYEDKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYVIGNHKQDEAYPLSKAVENSGKVPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFADHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTLVANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAGQENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGAPVTHKGDESGLAPTTEVKPRLDIQKEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADGKEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPAEESKALPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ankur B Dalia, Alistair J Standish, Jeffrey N Weiser
Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils.
Infect Immun: 2010, 78(5);2108-16
[PubMed:20160017] [WorldCat.org] [DOI] (I p)

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