PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 17-DEC-2024

⊟Summary

• organism: Streptococcus pneumoniae A66
• locus tag: A66_RS02445 [old locus tag: A66_00488 ]
• pan locus tag^?: PNEUPAN001406000
• symbol: A66_RS02445
• pan gene symbol^?: blpO
• synonym:
• product: Blp family class II bacteriocin

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: A66_RS02445 [old locus tag: A66_00488 ]
• symbol: A66_RS02445
• product: Blp family class II bacteriocin
• replicon: chromosome
• strand: +
• coordinates: 464987..465217
• length: 231
• essential: unknown

⊟Accession numbers

• Location: NZ_LN847353 (464987..465217) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  
  ATGGATACAAAAATGATGTCACAATTTTCTGTTATGGATAATGAAATGCTTGCTCGTGTT
  GAAGGTGGCGGATGCAATTGGGGAGATTTTGCCAAAGCAGGTGTTGGAGGAGGAGCAGCA
  AGAGGTCTTCAACTAGGCATTAAAACAGGAACATGGCAAGGTGCAGCAACTGGTGCTGCG
  GGTGGAGCTATACTTGGAGGTGTAGCCTATGCAGCAACATGTTGGTGGTAA
  60
  120
  180
  231
  

⊟Protein

⊟General

• locus tag: A66_RS02445 [old locus tag: A66_00488 ]
• symbol: A66_RS02445
• description: Blp family class II bacteriocin
• length: 76
• theoretical pI: 6.38648
• theoretical MW: 7644.68
• GRAVY: 0.157895

⊟Function

• TIGRFAM:
  class IIb bacteriocin, lactobin A/cerein 7B family (TIGR03949; HMM-score: 20)
  and 1 more
  bacteriocin-type signal sequence (TIGR01847; HMM-score: 15.4)
• TheSEED: data available for TIGR4
• PFAM:
  GG-leader (CL0400) Bacteriocin_IIc; Bacteriocin class II with double-glycine leader peptide (PF10439; HMM-score: 54.8)
  and 4 more
  ComC; COMC family (PF03047; HMM-score: 17.1)
  Glycine-zipper (CL0500) Gly-zipper_YMGG; YMGG-like Gly-zipper (PF13441; HMM-score: 10.8)
  Gly-zipper_Omp; Glycine zipper (PF13488; HMM-score: 7)
  TerB (CL0414) DUF533; Protein of unknown function (DUF533) (PF04391; HMM-score: 6.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• DeepLocPro: Extracellular
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0
  • Cell wall & surface Score: 0
  • Extracellular Score: 1
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.331289
  • TAT(Tat/SPI): 0.02888
  • LIPO(Sec/SPII): 0.008855
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000379961 NCBI
• UniProt:

⊟Protein sequence

• MDTKMMSQFSVMDNEMLARVEGGGCNWGDFAKAGVGGGAARGLQLGIKTGTWQGAATGAAGGAILGGVAYAATCWW

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications