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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS04520 [old locus tag: A66_00908 ]
  • pan locus tag?: PNEUPAN001991000
  • symbol: A66_RS04520
  • pan gene symbol?: mtnN
  • synonym:
  • product: 5'-methylthioadenosine/adenosylhomocysteine nucleosidase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS04520 [old locus tag: A66_00908 ]
  • symbol: A66_RS04520
  • product: 5'-methylthioadenosine/adenosylhomocysteine nucleosidase
  • replicon: chromosome
  • strand: +
  • coordinates: 866417..867109
  • length: 693
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (866417..867109) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0877 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAAATAGGAATTATTGCTGCTATGCCAGAAGAACTGGCTTATCTGGTCCAGCATTTA
    GATAATGCCCAGGAGCAAGTTGTTTTGGGGAATACCTATCATACAGGAACCATTGCTTCT
    CATGAAGTCGTTCTTGTAGAAAGTGGAATTGGTAAGGTCATGTCTGCTATGAGTGTGGCG
    ATTTTGGCTGATCATTTCCAGGTGGATGCCCTTATTAATACGGGTTCAGCTGGGGCAGTA
    GCAGAAGGTATCGCTGTTGGGGATGTCGTGATTGCTGACAAATTAGCCTATCATGACGTG
    GATGTCACAGCTTTTGGCTATGCTTATGGACAAATGGCGCAACAACCGCTTTATTTCGAA
    TCAGACAAAACCTTTGTTGCTCAAATCCAAGAGAGTTTATCTCAATTGGACCAAAACTGG
    CATCTTGGTTTGATTGCTACAGGAGATAGTTTTGTTGCAGGAAATGACAAGATAGAAGCG
    ATTAAGTCCCATTTCCCAGAAGTTTTAGCCGTGGAGATGGAGGGGGCAGCTATTGCTCAA
    GCAGCGCATGCCCTCAATCTCCCAGTCTTAGTCATCCGAGCTATGAGTGACAATGCCAAC
    CATGAAGCAAACATCTTTTTTGATGAGTTTATTATCGAAGCTGGACGTCGCTCTGCCCAA
    GTCTTGTTGACCTTTTTGAAGGCTTTAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    693

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS04520 [old locus tag: A66_00908 ]
  • symbol: A66_RS04520
  • description: 5'-methylthioadenosine/adenosylhomocysteine nucleosidase
  • length: 230
  • theoretical pI: 4.29334
  • theoretical MW: 24650.8
  • GRAVY: 0.316087

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.2.9?  ExPASy
    Adenosylhomocysteine nucleosidase S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides MTA/SAH nucleosidase (TIGR01704; EC 3.2.2.16,3.2.2.9; HMM-score: 221.2)
    Metabolism Central intermediary metabolism Other MTA/SAH nucleosidase (TIGR01704; EC 3.2.2.16,3.2.2.9; HMM-score: 221.2)
    and 6 more
    futalosine hydrolase (TIGR03664; EC 3.2.2.26; HMM-score: 86.5)
    hopanoid-associated phosphorylase (TIGR03468; HMM-score: 65.4)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides purine nucleoside phosphorylase (TIGR00107; EC 2.4.2.1; HMM-score: 51.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine phosphorylase (TIGR01718; EC 2.4.2.3; HMM-score: 31.3)
    putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (TIGR01705; HMM-score: 22)
    putative AMP nucleosidase (TIGR01721; HMM-score: 18.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PUP (CL0408) PNP_UDP_1; Phosphorylase superfamily (PF01048; HMM-score: 172.6)
    and 1 more
    no clan defined DUF2884; Protein of unknown function (DUF2884) (PF11101; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.32
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.12
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9987
    • Cytoplasmic Membrane Score: 0
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0012
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.0058
    • TAT(Tat/SPI): 0.000125
    • LIPO(Sec/SPII): 0.000336
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000689777 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIGIIAAMPEELAYLVQHLDNAQEQVVLGNTYHTGTIASHEVVLVESGIGKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDVTAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAIKSHFPEVLAVEMEGAAIAQAAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRSAQVLLTFLKALD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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