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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
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670-6B
serotype 6B
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serotype 3
AP200
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ATCC 700669
serotype 23F
BM6001
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G54
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HU-OH
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS05660 [old locus tag: A66_01134 ]
  • pan locus tag?: PNEUPAN002500000
  • symbol: A66_RS05660
  • pan gene symbol?: —
  • synonym:
  • product: pyridoxal phosphate-dependent decarboxylase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS05660 [old locus tag: A66_01134 ]
  • symbol: A66_RS05660
  • product: pyridoxal phosphate-dependent decarboxylase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1101231..1102658
  • length: 1428
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (1101231..1102658) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGAAAATTTTGGATTACTAAACTTAGAAAATAAGGAATATTTTGAGAGGGAATTAATG
    TCTTTAATTAGTTCTCTTATTGATTGGAAAATTGATAACTCTATCGTTAGACGCTCTAAT
    GATAGACATGAGATTATTGAGATTGCCCCATTACCTAAATCAGGACAAAGATTAAATGAT
    TCTATTAGGTATATTTTGAATACAATTGATAGAAATATAAATTTTTCGAGTAATAAATTT
    ATGGGTTTTCCAGACGCAGGAAATTCATTAGCGGGATTGGCAGCAGCAATAATTGAAGTT
    TTTCTCCAGCAGAATCTTATAAATAAGGATATTTGCTCACCTATGGGAAGTGAAATTGAA
    GCAGAAGTTATTATTTGGCTGAGACAAATTTTGGGTTATTCTTTTGATGATAAAATATAT
    GACGTTACTAAATTAGGAGGAGCAGTCACAACTGGTGGAGTAATGTCAAATACCTATGCT
    CTTATGGCAGCTAAACGAAAATATCCTAATAAAAGAATTGTAATACTTCCAGATAATATA
    GGGCACTACTCATTAAGCTATGCAACTGAATGGCTTAATCTTGGAGTTGAGGTTATATAC
    TGTAAGACTGAGAAATATAAGATTAACCAGTCGGAATTATCAAAATTGCTTCAAAAATAT
    GGTGAAAATGTACTTTTTATAGGTGTTTATGCATGCGATTCAATGACATCGACTTGTGAA
    GATTTGGAAGGAATCTACAAAATCGTAAATAATTATAGTACGGATATTTGGCTGCACGCA
    GATGCATGCCATGGATTTGTATTGGTTTTTTCAGAACACTACAAAAATAGAATAGAATAT
    CTAAAGTATTTCGATAGTTGTACGATGGATCCACATAAAGTCCTCTGGATACCATATACA
    CTTAGTATTATCTTAATGAAAAATACAGATGATTTTGCAAGTCTTTCAAGATCTAATGCA
    TTAATTATGGATGATCCATTATCCTTTGGAAAAACAACTCCTTTTATTGGAAGTAAATCT
    TATGATAGTTTAAAATTGTGGATGGTTATGAAGACACTTGGAACTCAGAAAATAGGTGAA
    ATGGCGGAGAGCAGGATTGAAAATGCAAAGAAATTTTATAATATTCTGAGTGAAAATAAT
    GCATTTATTATGGCAAATACAGATATATTATTTTCTGTTATCTTTCAGTACACTCCTAGA
    TTGGATATATCGATTAATCAAATGAACACTTTGAATAGAAAAATATATGATAAAATGTTA
    CTTGATGGTAAATTCTATTTTCATGGTTTTGAAATTAATGTAAATGGTGTCAATAGATTC
    GTTCTTCGATACAATAGTGGTAATATTAATATTACCGAAGTAGAGTTGGAAGATGCTGTA
    AAATATATTGAAAAGATTGGGAAAGAGGTATCTAATGAACAAAATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1428

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: A66_RS05660 [old locus tag: A66_01134 ]
  • symbol: A66_RS05660
  • description: pyridoxal phosphate-dependent decarboxylase family protein
  • length: 475
  • theoretical pI: 5.54036
  • theoretical MW: 54461.2
  • GRAVY: -0.162737

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.1.-?  ExPASy
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A putative pyridoxal-dependent aspartate 1-decarboxylase (TIGR03799; EC 4.1.1.-; HMM-score: 80.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other tyrosine decarboxylase MnfA (TIGR03812; EC 4.1.1.25; HMM-score: 76.7)
    and 2 more
    cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 17.2)
    Genetic information processing DNA metabolism Restriction/modification cysteine desulfurase DndA (TIGR03235; EC 2.8.1.7; HMM-score: 15.5)
  • TheSEED:
  • PFAM:
    PLP_aminotran (CL0061) Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain (PF00282; HMM-score: 104.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.6238
    • Cytoplasmic Membrane Score: 0.0638
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.3119
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002205
    • TAT(Tat/SPI): 0.000304
    • LIPO(Sec/SPII): 0.000379
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_053039637 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MENFGLLNLENKEYFERELMSLISSLIDWKIDNSIVRRSNDRHEIIEIAPLPKSGQRLNDSIRYILNTIDRNINFSSNKFMGFPDAGNSLAGLAAAIIEVFLQQNLINKDICSPMGSEIEAEVIIWLRQILGYSFDDKIYDVTKLGGAVTTGGVMSNTYALMAAKRKYPNKRIVILPDNIGHYSLSYATEWLNLGVEVIYCKTEKYKINQSELSKLLQKYGENVLFIGVYACDSMTSTCEDLEGIYKIVNNYSTDIWLHADACHGFVLVFSEHYKNRIEYLKYFDSCTMDPHKVLWIPYTLSIILMKNTDDFASLSRSNALIMDDPLSFGKTTPFIGSKSYDSLKLWMVMKTLGTQKIGEMAESRIENAKKFYNILSENNAFIMANTDILFSVIFQYTPRLDISINQMNTLNRKIYDKMLLDGKFYFHGFEINVNGVNRFVLRYNSGNINITEVELEDAVKYIEKIGKEVSNEQN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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