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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_RS08225 [old locus tag: A66_01653 ]
  • pan locus tag?: PNEUPAN003345000
  • symbol: A66_RS08225
  • pan gene symbol?: paaI
  • synonym:
  • product: PaaI family thioesterase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: A66_RS08225 [old locus tag: A66_01653 ]
  • symbol: A66_RS08225
  • product: PaaI family thioesterase
  • replicon: chromosome
  • strand: -
  • coordinates: 1580713..1581117
  • length: 405
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NZ_LN847353 (1580713..1581117) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1632 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    ATGAAAGACTTTCATTTTGACGCTATATCTGCCTTTGAAAATTACGAAATTGAAAAAATG
    AGAGATGGTCACGTTGTGGTGACGACCAAAGTAGTGAACTCGTCGCTCAACTACTATGGC
    AATGCCCATGGTGGCTATCTATTCACGCTATGTGACCAAATCAGTGGTTTGGTGGTTATC
    TCGCTGGGACTTGATGGGGTGACACTCCAATCCTCTATCAACTACCTTAAGGCAGGAAAA
    CTCGACGATGTATTGACCATTAAAGGAGAATGTGTCCATCAAGGTCGTACAACCTGTGTG
    ATGGATGTGGATATCACCAATCAAGAGGGCAGAAATGTCTGTAAGGCAACCTTTACTATG
    TTTGTCACAGGCCAGCGGTCAGAAGAAAGACAGGTAAGTATATAA
    60
    120
    180
    240
    300
    360
    405

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: A66_RS08225 [old locus tag: A66_01653 ]
  • symbol: A66_RS08225
  • description: PaaI family thioesterase
  • length: 134
  • theoretical pI: 5.57111
  • theoretical MW: 14847.8
  • GRAVY: -0.0738806

Function[edit | edit source]

  • TIGRFAM:
    phenylacetic acid degradation protein PaaD (TIGR02286; HMM-score: 66.9)
    uncharacterized domain 1 (TIGR00369; HMM-score: 66.2)
    and 2 more
    Unknown function General acyl-CoA thioester hydrolase, YbgC/YbaW family (TIGR00051; HMM-score: 28.7)
    tol-pal system-associated acyl-CoA thioesterase (TIGR02799; EC 3.1.2.-; HMM-score: 19.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HotDog (CL0050) 4HBT; Thioesterase superfamily (PF03061; HMM-score: 70.1)
    and 3 more
    DUF4442; Domain of unknown function (DUF4442) (PF14539; HMM-score: 27.7)
    4HBT_3; Thioesterase-like superfamily (PF13622; HMM-score: 26.1)
    Acyl-ACP_TE; Acyl-ACP thioesterase (PF01643; HMM-score: 17.3)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.076479
    • TAT(Tat/SPI): 0.000431
    • LIPO(Sec/SPII): 0.000542
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000651212 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MKDFHFDAISAFENYEIEKMRDGHVVVTTKVVNSSLNYYGNAHGGYLFTLCDQISGLVVISLGLDGVTLQSSINYLKAGKLDDVLTIKGECVHQGRTTCVMDVDITNQEGRNVCKATFTMFVTGQRSEERQVSI

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]