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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 03-SEP-2019

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ASP0581
  • locus tag: ASP0581_15650 [new locus tag: EL334_RS08270 ]
  • pan locus tag?: PNEUPAN003006000
  • symbol: ASP0581_15650
  • pan gene symbol?: manR
  • synonym:
  • product: transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: ASP0581_15650 [new locus tag: EL334_RS08270 ]
  • symbol: ASP0581_15650
  • product: transcriptional regulator
  • replicon: chromosome
  • strand: -
  • coordinates: 1544066..1545529
  • length: 1464
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AP019192 (1544066..1545529) NCBI
  • BioCyc: see EL334_RS08270
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    GTGTCTAGAAAACAAGAACAAATGGAAACGTTGTTGCTCCTTTTGCGAGATAGTAAGGAT
    TATATATCTGCTAAAGTATTGGGAGAAAAATTAAATTGCTCTGATAAAACGGTTTATCGC
    CTTGTCAAGGTAATCAACAAAGATTGTCCGGTAGAAGCATTCATTTTATCTGAAAAAGGC
    AGAGGTTTCAAATTAAATCCAAGAAGTTCCCTCGTGGACGTTGATGGGAATTTTACAGAG
    GCTTTTGATCCTGAAGTAAGGCGTGAAAAATTACTAGAACGTCTCTTGTTGACTGCTCCT
    AAGCCACATTCTATTTATGATTTAGGAGAGGAATTCTACGTAAGCGAGTCAGTAGTACTA
    AAAGATCGTCAGATATTACAAGAGAGTCTAGCAATTTATGGGTTAGATTTAAAAATGAGA
    CAACGAAAGCTTTTTATTGATGGGGATGAGGCTCAAATTCGTTCAGCCATTCTAAATCTA
    CTGCCAATGTTTAATCAGTTGGATTTAGAGCAAATTACACAGAATAAGGTTCAGCCTCTT
    GACGGAGAACTTGCTCACTTTTGTTTGGGATTACTGATTACACTTGAGAGAGAATTGGGG
    GTAAACATTCCCTATCCATATAATATAAATATTTTCTCTCACCTGTATATTTTTATCAGT
    AGGAATCGTCGTAGTACTAGTATTCATGTTGTAGCACCTTCAAAACCTACTATTGTTGAT
    GAGAAAATTTACAGTGTCTGTCAAAAAATTATTCAAGAAATTGAACAATATTTTAAGATG
    AAGGTTGATGCAGTTGAGATTGACTATCTTTATCAATACGTTGTATCTTCGAGATTGCAA
    AAACCATTTTCTTCCGGGAAGCTTCCTTTTTCTCAGCGAGTTTTAGATGTCACTCATTAC
    TATTTTAGCCGTATGTGTATGGACAATAGAGAGATTGAAACGACAGATCCTGACTTTGTT
    GACTTGGCGAGTCATATCAGTCCCTTACTGAGGAGATTAGATAATAGAGTACAGATTAAG
    AATAGTCTTTTATCACAAATTCTTTTAACCTATCCTAATCTGGTTAAAGAGTTAACAACT
    ATTTCTAAAGAAGTGAGTCTAGTATTTGGTTTTGCGTCCTTGAGTCTGGACGAGATTGGT
    TTTCTAGTCTTATATTTTGCACGGTTTCAAGAAAAGCGAGCACGTCCTCTAAAAACAGTA
    GTGATGTGTACATCAGGTGTCGGAACTTCAGAGCTTTTACGAGCACGATTAGAAAAGCAA
    TTTACTGAATTGGATATTATTGATGTAGTTGCTTATCATCAATTAGATGAGCTGATAAAT
    CTATATCCAGATTTAGATTTCATTGTGACGACGGTAGCTTTGCAGGAACCAGCAAGTGTC
    CCGTTTGTCCTAGTTAGTGTTTTTCTAACCGAGGGTGATAAACAACGTCTTCAAGCAAAA
    ATTCAGGAGATAAACTATGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1464

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: ASP0581_15650 [new locus tag: EL334_RS08270 ]
  • symbol: ASP0581_15650
  • description: transcriptional regulator
  • length: 487
  • theoretical pI: 5.77979
  • theoretical MW: 56144.6
  • GRAVY: -0.0827515

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for Hungary19A-6, TIGR4
  • PFAM:
    PRD (CL0166) PRD; PRD domain (PF00874; HMM-score: 62.3)
    HTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 58.5)
    and 3 more
    Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 37.2)
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 21.2)
    HTH (CL0123) HTH_23; Homeodomain-like domain (PF13384; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.019898
    • TAT(Tat/SPI): 0.001367
    • LIPO(Sec/SPII): 0.003156
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBG82087 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSRKQEQMETLLLLLRDSKDYISAKVLGEKLNCSDKTVYRLVKVINKDCPVEAFILSEKGRGFKLNPRSSLVDVDGNFTEAFDPEVRREKLLERLLLTAPKPHSIYDLGEEFYVSESVVLKDRQILQESLAIYGLDLKMRQRKLFIDGDEAQIRSAILNLLPMFNQLDLEQITQNKVQPLDGELAHFCLGLLITLERELGVNIPYPYNINIFSHLYIFISRNRRSTSIHVVAPSKPTIVDEKIYSVCQKIIQEIEQYFKMKVDAVEIDYLYQYVVSSRLQKPFSSGKLPFSQRVLDVTHYYFSRMCMDNREIETTDPDFVDLASHISPLLRRLDNRVQIKNSLLSQILLTYPNLVKELTTISKEVSLVFGFASLSLDEIGFLVLYFARFQEKRARPLKTVVMCTSGVGTSELLRARLEKQFTELDIIDVVAYHQLDELINLYPDLDFIVTTVALQEPASVPFVLVSVFLTEGDKQRLQAKIQEINYE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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