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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7465
  • locus tag: AT689_RS02750 [old locus tag: ERS445053_00542 ]
  • pan locus tag?: PNEUPAN003934000
  • symbol: guaB
  • pan gene symbol?: guaB
  • synonym:
  • product: IMP dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: AT689_RS02750 [old locus tag: ERS445053_00542 ]
  • symbol: guaB
  • product: IMP dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 510763..512241
  • length: 1479
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN831051 (510763..512241) NCBI
  • BioCyc: AT689_RS02750 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2055 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGTCTAATTGGGACACTAAATTTTTGAAAAAAGGTTTTACCTTTGATGATGTATTGCTT
    ATTCCAGCTGAAAGTCATGTGTTGCCTAACGATGCAGATTTAACAACTAAATTGGCAGAT
    AATTTGACTTTAAATATCCCAATTATTACCGCTGCCATGGACACAGTTACAGAGAGTCAA
    ATGGCCATTGCTATTGCTCGTGCAGGTGGTCTCGGAGTTATCCATAAAAACATGTCAATT
    GCTCAACAAGCAGACGAGGTTCGTAAGGTAAAACGTTCTGAAAATGGAGTTATTATTGAT
    CCGTTCTTCTTGACGCCTGAACATACAATTGCTGAAGCAGATGAGCTTATGGGTCGTTAC
    CGCATCAGTGGTGTTCCAGTTGTTGAAACACTTGAAAATCGTAAATTGGTTGGTATTTTG
    ACAAACCGAGATCTTCGTTTTATTTCAGATTATAATCAACCAATTTCAAACCATATGACT
    AGTGAAAATCTTGTTACTGCTCCTGTGGGTACGGATCTTGCAACGGCTGAGAGTATTCTT
    CAAGAGCATCGTATTGAAAAACTTCCGTTGGTCGATGAAGAAGGCAGTCTTTCTGGTTTG
    ATCACTATCAAAGATATTGAAAAAGTTATTGAGTTTCCAAATGCGGCTAAAGATGAATTT
    GGTCGTCTTCTAGTTGCAGGTGCAGTAGGTGTTACTTCAGATACATTTGAACGTGCAGAG
    GCTCTTTTTGAGGCAGGAGCGGATGCGATTGTTATTGATACTGCACATGGTCATTCTGCA
    GGTGTCTTGCGTAAAATTGCCGAGATTCGTGCTCATTTCCCAGATCGGACTTTGATTGCT
    GGAAATATTGCTACTGCTGAAGGTGCACGTGCCCTTTATGAAGCGGGTGTAGACGTTGTT
    AAGGTTGGTATTGGACCAGGTTCTATCTGTACTACTCGTGTGATTGCTGGTGTTGGTGTT
    CCGCAAGTAACAGCTATCTACGATGCTGCAGCTGTTGCGCGCGAATATGGTAAAACGATT
    ATTGCTGACGGTGGGATCAAGTATTCTGGAGATATTGTAAAAGCACTTGCTGCAGGTGGA
    AATGCTGTTATGCTTGGATCTATGTTTGCTGGAACTGATGAAGCTCCAGGCGAAACTGAA
    ATCTTCCAAGGACGTAAATTCAAGACTTACCGTGGTATGGGATCAATTGCTGCTATGAAG
    AAAGGTTCAAGCGACCGTTATTTCCAAGGTTCTGTCAATGAAGCAAACAAGCTCGTTCCA
    GAAGGAATTGAAGGTCGTGTTGCTTATAAAGGAGCGGCAGCTGATATTGTTTTCCAAATG
    ATTGGTGGTATTCGCTCTGGTATGGGTTACTGTGGTGCAGCTAACCTTAAAGAACTACAC
    GATAATGCTCAATTTATTGAAATGTCTGGTGCTGGTTTGAAAGAAAGCCATCCTCATGAT
    GTGCAAATTACTAATGAGGCACCAAAGTATTCTATGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1479

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: AT689_RS02750 [old locus tag: ERS445053_00542 ]
  • symbol: GuaB
  • description: IMP dehydrogenase
  • length: 492
  • theoretical pI: 5.05848
  • theoretical MW: 52458.4
  • GRAVY: -0.0132114

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.205?  ExPASy
    IMP dehydrogenase Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis inosine-5'-monophosphate dehydrogenase (TIGR01302; EC 1.1.1.205; HMM-score: 640.7)
    and 15 more
    Unknown function General IMP dehydrogenase family protein (TIGR01303; HMM-score: 310.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanosine monophosphate reductase (TIGR01305; EC 1.7.1.7; HMM-score: 195.6)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions guanosine monophosphate reductase (TIGR01306; EC 1.7.1.7; HMM-score: 156.3)
    Unknown function General IMP dehydrogenase family protein (TIGR01304; HMM-score: 111.9)
    putative enoyl-[acyl-carrier-protein] reductase II (TIGR03151; EC 1.3.1.-; HMM-score: 29.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium transporter (TIGR00400; HMM-score: 28)
    Metabolism Energy metabolism Sugars sugar isomerase, KpsF/GutQ family (TIGR00393; HMM-score: 22.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 21.3)
    heme/flavin dehydrogenase, mycofactocin system (TIGR03966; EC 1.-.-.-; HMM-score: 20.9)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 19.9)
    Metabolism Amino acid biosynthesis Serine family cystathionine beta-synthase (TIGR01137; EC 4.2.1.22; HMM-score: 16.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other isopentenyl-diphosphate delta-isomerase, type 2 (TIGR02151; EC 5.3.3.2; HMM-score: 16)
    phosphoenolpyruvate mutase (TIGR02320; EC 5.4.2.9; HMM-score: 15)
    geranylgeranylglyceryl phosphate synthase family protein (TIGR01768; EC 2.5.1.-; HMM-score: 10.1)
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 9.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    TIM_barrel (CL0036) IMPDH; IMP dehydrogenase / GMP reductase domain (PF00478; HMM-score: 530.4)
    and 7 more
    no clan defined CBS; CBS domain (PF00571; HMM-score: 60.6)
    TIM_barrel (CL0036) NMO; Nitronate monooxygenase (PF03060; HMM-score: 37.2)
    FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 28.6)
    PK_TIM (CL0151) PEP_mutase; Phosphoenolpyruvate phosphomutase (PF13714; HMM-score: 16.6)
    TIM_barrel (CL0036) His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 16.3)
    QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 16)
    Glu_synthase; Conserved region in glutamate synthase (PF01645; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8359
    • Cytoplasmic Membrane Score: 0.0098
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.154
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004571
    • TAT(Tat/SPI): 0.000214
    • LIPO(Sec/SPII): 0.000512
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000073427 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTLNIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMTSENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFIEMSGAGLKESHPHDVQITNEAPKYSM

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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