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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7465
  • locus tag: AT689_RS04190 [old locus tag: ERS445053_00813 ]
  • pan locus tag?: PNEUPAN003585000
  • symbol: AT689_RS04190
  • pan gene symbol?: lon
  • synonym:
  • product: SepM family pheromone-processing serine protease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: AT689_RS04190 [old locus tag: ERS445053_00813 ]
  • symbol: AT689_RS04190
  • product: SepM family pheromone-processing serine protease
  • replicon: chromosome
  • strand: +
  • coordinates: 781312..782820
  • length: 1509
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN831051 (781312..782820) NCBI
  • BioCyc: AT689_RS04190 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1765 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGTCAGATAAGATTGGCTTATTCACAGGCTCATTTGATCCGATGACAAATGGGCATCTG
    GATATCATTGAACGGGCGAGCAGACTCTTTGATAAGCTCTATGTCGGTATTTTTTTTAAT
    CCCCACAAACAAGGATTTCTTCCTATCGAAAATCGTAAACGGGGGCTAGAAAAGGCTTTG
    GGACATCTGGAAAATGTTGAAGTCGTGGCTTCTCATGATGAATTGGTGGTCGATGTTGCA
    AAAAGATTGGGTGCTACTTGTCTAGTGCGTGGTTTGAGGAATGCGTCGGATTTGCAATAT
    GAAGCCAGTTTTGATTACTACAATCATCAGCTGTCTTCTGATATAGAGACTATTTATTTA
    CATAGTCGACCTGAACATCTCTATATCAGTTCATCAGGCGTTAGAGAGCTTTTGAAGTTT
    GGTCAGGATATTGCCTGCTATGTTCCCGAGAGTATTTTGGAGGAAATAAGAAATGAAAAA
    AAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTA
    GTGCCCTTGCCTTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTT
    AAAGTAAATGACACAGAAGATAAGGAAGCTGGTGCCTATCAATTCGTTACGGTTGGTGTT
    CAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACAGATATTCGT
    AGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTC
    TACATGCAAACATCACAAAATATGGCCAAGTATCAAGGTCTAAAAACAGCTGGTAAGGAT
    ATCGAACTCAAGTACTTTGGGGTTTATGTCTTGAATGTGACGGATAATTCAACCTTTAAA
    GGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTTGATAGTTCC
    AAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTAT
    GAAGAGGATGGGCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAA
    AATGGAATTGGAATCGGCTTGATTGATCGTACAGAGGTAATCAGCAATGTCCCAATTAGC
    TTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTAGCTATCTAT
    ACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATT
    GACCGCGATGGTAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCT
    AGGGCAGGTGCTGCTATTTTCTTTGCTCCTGATAACCCTGTTAGCGAAGAAGAACAAAAG
    GCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAAACAATCAAG
    ACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAAC
    AATCCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1509

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: AT689_RS04190 [old locus tag: ERS445053_00813 ]
  • symbol: AT689_RS04190
  • description: SepM family pheromone-processing serine protease
  • length: 502
  • theoretical pI: 5.13793
  • theoretical MW: 55359.3
  • GRAVY: -0.195418

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.21.-?  ExPASy
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantetheine-phosphate adenylyltransferase (TIGR01510; EC 2.7.7.3; HMM-score: 178)
    and 15 more
    cytidyltransferase-like domain (TIGR00125; HMM-score: 55.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate (nicotinamide) nucleotide adenylyltransferase (TIGR00482; EC 2.7.7.18; HMM-score: 42.6)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 34.3)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 34.3)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 20.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 20.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 19.8)
    Genetic information processing Protein fate Protein folding and stabilization peptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 19.8)
    nicotinamide-nucleotide adenylyltransferase (TIGR01526; EC 2.7.7.1; HMM-score: 19.3)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides endopeptidase La (TIGR00763; EC 3.4.21.53; HMM-score: 18.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides RIP metalloprotease RseP (TIGR00054; EC 3.4.24.-; HMM-score: 17.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 16.9)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glycerol-3-phosphate cytidylyltransferase (TIGR01518; EC 2.7.7.39; HMM-score: 14.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain II (TIGR02199; EC 2.7.7.-; HMM-score: 14.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinamide-nucleotide adenylyltransferase (TIGR01527; EC 2.7.7.1; HMM-score: 13.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HUP (CL0039) CTP_transf_like; Cytidylyltransferase-like (PF01467; HMM-score: 53.8)
    and 6 more
    PDZ-like (CL0466) PDZ_2; PDZ domain (PF13180; HMM-score: 39.9)
    S5 (CL0329) Lon_C; Lon protease (S16) C-terminal proteolytic domain (PF05362; HMM-score: 28.4)
    Peptidase_MA (CL0126) Peptidase_M50; Peptidase family M50 (PF02163; HMM-score: 20.1)
    HUP (CL0039) Citrate_ly_lig; Citrate lyase ligase C-terminal domain (PF08218; HMM-score: 19.8)
    AOC_barrel (CL0650) AOC_like; Allene oxide cyclase barrel like domain (PF18678; HMM-score: 15.6)
    Cdc48_2-like (CL0402) UFD1; Ubiquitin fusion degradation protein UFD1 (PF03152; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0011
    • Cytoplasmic Membrane Score: 0.9885
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.01
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001095
    • TAT(Tat/SPI): 0.000221
    • LIPO(Sec/SPII): 0.000222
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001280730 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQGFLPIENRKRGLEKALGHLENVEVVASHDELVVDVAKRLGATCLVRGLRNASDLQYEASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFTDIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTFDSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAKTIKTDMKIVPVKTLQDAIDYLKNNP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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