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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-OCT-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7465
  • locus tag: AT689_RS04625 [old locus tag: ERS445053_00901 ]
  • pan locus tag?: PNEUPAN003418000
  • symbol: AT689_RS04625
  • pan gene symbol?: tacL
  • synonym:
  • product: O-antigen ligase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: AT689_RS04625 [old locus tag: ERS445053_00901 ]
  • symbol: AT689_RS04625
  • product: O-antigen ligase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 850138..851331
  • length: 1194
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LN831051 (850138..851331) NCBI
  • BioCyc: AT689_RS04625 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1672 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    TTGAAATCAATAGGCTTTATTGAAAAGCTGAAGGGGTTGTCTAGTAAAGAGCTGATTTTA
    TTGGGAATTATCCTAAGTATCTTTTTACCCTTTTATCTTTTTGTAGTTGTACTCTGTTTA
    TATATTATCAGTTTGATTTTTACAGGAGACATGAAAAGTATTCTTCAGAAAATGGGGGAG
    CATCCGATGCTGCTTCTTTTTCTTAGCTATAGTACTGTTATATCCATTCTTGCACAAAAT
    TGGATGGGTCTTGTGGCTTCAGTAGGAATGTTTCTATTTACTATTTTCTTTTTGCACTAT
    CAGTCGATTTTATCCCATAAATTCTTTCGATTGATTTTGCAGTTCGTCTTGTTTGGTAGT
    GTCTTGTCAGCTGCTTTTGCCAGTTTAGAACATTTCCAAATTGTGAAGAAATTTAACTAT
    GCTTTTCTTTCACCCAATATGCAGGTGTGGCATCAGAACCGGGCAGAAGTGACCTTCTTT
    AATCCTAATTATTATGGAATTATTTGTTGTTTCTGTATTATGATTGCTTTCTATCTGTTT
    ACAACGACCAAGTTGAATTGGTTGAAAGTATTCTGTGTGATTGCAGGCTTTGTTAATCTC
    TTTGGTTTGAACTTTACTCAAAATCGAACTGCCTTTCCTGCTATTATCGCTGGAGCAATT
    ATCTATCTCTTTACGACTATTAAAAACTGGAAGGCCTTTTGGCTTAGTATTGGGGTCTTC
    GCGATTGGTTTGAGTTTCCTCTTTTCTAGTGATTTGGGAGTTCGAATGGGTACTTTAGAC
    TCTTCTATGGAAGAACGCATTTCTATCTGGGATGCTGGGATGGCCTTGTTTAAGCAAAAT
    CCTTTTTGGGGTGAAGGGCCATTGACCTATATGCACTCTTATCCTCGGATACATGCTCCT
    TATCATGAACATGCCCACAGTCTTTATATTGATACGATTCTGAGTTACGGAATTGTGGGT
    ACCATTTTATTAGTTTTGTCTTCTGTTGCTCCTGTTCGCTTGATGATGGATATGAGTCAG
    GAGTCGGGGAAACGTCCGATTATCGGCCTTTATCTATCTTTCCTTACAGTGGTTGCTGTG
    CACGGAATTTTTGACTTGGCTCTCTTCTGGATTCAGTCAGGCTTTATTTTCTTGCTAGTT
    ATGTGCAGTATTCCATTGGAGCATCGAATGTTGGTATCGGACATGACGGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1194

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: AT689_RS04625 [old locus tag: ERS445053_00901 ]
  • symbol: AT689_RS04625
  • description: O-antigen ligase family protein
  • length: 397
  • theoretical pI: 8.54379
  • theoretical MW: 45207.7
  • GRAVY: 0.796977

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids putative bicarbonate transporter, IctB family (TIGR00947; HMM-score: 29.1)
    and 1 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides oligosaccharide repeat unit polymerase (TIGR04370; HMM-score: 12.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    O-anti_assembly (CL0499) Wzy_C; O-Antigen ligase (PF04932; HMM-score: 47.8)
    and 2 more
    no clan defined Mst1_SARAH; C terminal SARAH domain of Mst1 (PF11629; HMM-score: 12.7)
    DUF6703; Family of unknown function (DUF6703) (PF20444; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9986
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0013
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000624
    • TAT(Tat/SPI): 0.000132
    • LIPO(Sec/SPII): 0.003258
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000835622 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIISLIFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQSILSHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFFNPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAGAIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMALFKQNPFWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRLMMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLVSDMTD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Kaifeng Wu, Jian Huang, Yanqing Zhang, Wenchun Xu, Hongmei Xu, Libin Wang, Ju Cao, Xuemei Zhang, Yibing Yin
A novel protein, RafX, is important for common cell wall polysaccharide biosynthesis in Streptococcus pneumoniae: implications for bacterial virulence.
J Bacteriol: 2014, 196(18);3324-34
[PubMed:25002545] [WorldCat.org] [DOI] (I p)

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