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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SP49
  • locus tag: BMJ42_RS02980 [old locus tag: BMJ42_00562 ]
  • pan locus tag?: PNEUPAN001344000
  • symbol: BMJ42_RS02980
  • pan gene symbol?: cspR
  • synonym:
  • product: tRNA (cytidine(34)-2'-O)-methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: BMJ42_RS02980 [old locus tag: BMJ42_00562 ]
  • symbol: BMJ42_RS02980
  • product: tRNA (cytidine(34)-2'-O)-methyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 507894..508397
  • length: 504
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP018136 (507894..508397) NCBI
  • BioCyc: BMJ42_RS02980 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0436 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGACAAATCACATTGTATTATTTGAACCTCAAATTCCACAAAATACAGGCAATATCGCG
    CGTACTTGCGCTGCGACCAATTCTCCCCTCCACATCATCAAGCCTATGGGCTTTCCTATT
    GATGACCGCAAGATGAAGCGGGCTGGATTGGATTACTGGGATAAGCTAGAGATTTATTTT
    TACGAGAGTTTAGAAGATTTCATATCTCAGATGAAGGGAAAACTCTATCTGATTTCGAAA
    TTCGCGGAAAAAATCTATTCTGAGGTGGATTTATCGACTGACGAGGACCATTATTTTCTC
    TTTGGACGTGAAGACAAGGGCTTACCTGAAGATTTTATGCGAGAACATCCTGAGAAGGCT
    CTCCGTATTCCCATGAATGATGAACATGTCCGCAGTCTCAATGTGTCTAATACCGTCTGC
    ATGATTGTCTATGAGGCTCTTCGCCAGCAGAACTTTGCAGGTCTTGAGCTCGTCCATACC
    TATGAAGTGGATAAATTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    504

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: BMJ42_RS02980 [old locus tag: BMJ42_00562 ]
  • symbol: BMJ42_RS02980
  • description: tRNA (cytidine(34)-2'-O)-methyltransferase
  • length: 167
  • theoretical pI: 5.30297
  • theoretical MW: 19551.3
  • GRAVY: -0.442515

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.207?  ExPASy
    tRNA (cytidine34-2'-O)-methyltransferase S-adenosyl-L-methionine + cytidine34 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine34 in tRNA S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine34 in tRNA(Leu) = S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu)
  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA (cytidine(34)-2'-O)-methyltransferase (TIGR00185; EC 2.1.1.207; HMM-score: 186.9)
    and 2 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification RNA methyltransferase, TrmH family, group 1 (TIGR00050; EC 2.1.1.-; HMM-score: 36.3)
    Genetic information processing Protein synthesis tRNA and rRNA base modification RNA methyltransferase, TrmH family, group 3 (TIGR00186; HMM-score: 34.1)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    SPOUT (CL0098) SpoU_methylase; SpoU rRNA Methylase family (PF00588; HMM-score: 109.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9575
    • Cytoplasmic Membrane Score: 0.0012
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0412
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007537
    • TAT(Tat/SPI): 0.000792
    • LIPO(Sec/SPII): 0.003121
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000181373 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTNHIVLFEPQIPQNTGNIARTCAATNSPLHIIKPMGFPIDDRKMKRAGLDYWDKLEIYFYESLEDFISQMKGKLYLISKFAEKIYSEVDLSTDEDHYFLFGREDKGLPEDFMREHPEKALRIPMNDEHVRSLNVSNTVCMIVYEALRQQNFAGLELVHTYEVDKLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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