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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SP49
  • locus tag: BMJ42_RS03935 [old locus tag: BMJ42_00730 ]
  • pan locus tag?: PNEUPAN001597000
  • symbol: typA
  • pan gene symbol?: typA
  • synonym:
  • product: translational GTPase TypA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: BMJ42_RS03935 [old locus tag: BMJ42_00730 ]
  • symbol: typA
  • product: translational GTPase TypA
  • replicon: chromosome
  • strand: +
  • coordinates: 686969..688810
  • length: 1842
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP018136 (686969..688810) NCBI
  • BioCyc: BMJ42_RS03935 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0593 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATGACAAAATTAAGAGAAGATATCCGTAACATTGCGATTATCGCCCACGTTGACCACGGT
    AAAACAACCCTGGTTGACGAATTATTGAAACAATCAGAAACGCTTGATGCACGTACTGAA
    TTGGCAGAGCGTGCTATGGACTCAAACGATATCGAAAAAGAGCGTGGAATTACCATCCTT
    GCTAAAAATACTGCCGTTGCTTACAACGGAACTCGTATCAACATTATGGACACACCAGGA
    CACGCGGACTTCGGTGGAGAAGTTGAGCGTATCATGAAAATGGTTGACGGTGTTGTCTTG
    GTCGTAGATGCCTATGAAGGAACCATGCCACAAACTCGTTTCGTATTGAAAAAAGCCTTG
    GAACAAGACCTTGTCCCAATCGTGGTTGTTAACAAAATCGATAAGCCATCAGCTCGTCCA
    GCAGAAGTAGTGGATGAAGTCTTGGAACTTTTCATCGAGCTTGGTGCAGATGACGACCAG
    CTTGATTTCCCAGTGGTTTATGCTTCAGCGATCAACGGAACTTCTTCATTGTCAGATGAT
    CCAGCTGACCAAGAAGCGACTATGGCACCAATCTTTGACACGATTATCGACCATATCCCA
    GCTCCAGTAGATAACTCAGATGAGCCTTTGCAGTTCCAAGTGTCACTTTTGGACTACAAT
    GACTTCGTTGGACGTATCGGTATCGGTCGTGTCTTCCGTGGTACAGTTAAGGTTGGGGAC
    CAAGTTACCCTTTCTAAACTTGACGGTACAACTAAAAACTTCCGTGTTACAAAACTCTTC
    GGTTTCTTTGGTTTGGAACGTCGTGAAATCCAAGAAGCCAAAGCGGGTGACTTGATTGCC
    GTTTCAGGTATGGAAGACATCTTTGTCGGTGAAACCATCACTCCGACAGATGCAGTAGAA
    GCTCTTCCAATCCTACACATCGATGAGCCAACTCTTCAAATGACTTTCTTGGTCAACAAC
    TCACCATTTGCTGGTAAAGAAGGTAAATGGGTAACTTCTCGTAAGGTGGAAGAACGCTTG
    CAGGCAGAATTGCAAACAGACGTTTCCCTTCGTGTTGACCCAACTGATTCACCAGATAAA
    TGGACTGTTTCAGGACGTGGAGAATTGCACTTGTCAATCCTTATCGAAACAATGCGTCGT
    GAGGGCTATGAACTTCAAGTATCTCGTCCAGAAGTTATCGTAAAAGAAATCGACGGTGTT
    AAATGTGAACCATTTGAACGTGTACAAATCGACACTCCAGAAGAATACCAAGGGTCTGTT
    ATCCAAAGCCTTTCTGAACGTAAAGGTGAAATGTTGGATATGATTTCAACTGGTAATGGT
    CAAACTCGTTTGGTCTTCCTTGTTCCAGCGCGTGGTTTGATTGGATACTCAACTGAGTTC
    TTGTCAATGACTCGTGGTTACGGTATCATGAACCATACCTTCGACCAGTACTTGCCATTG
    ATTCCAGGGGAAATTGGTGGACGTCACCGTGGTGCCCTTGTTTCTATCGATGCTGGTAAG
    GCTACAACTTACTCAATCATGTCTATCGAAGAACGTGGTACGATCTTTGTCAACCCAGGT
    ACTGAGGTTTATGAAGGAATGATCATCGGCGAAAACTCTCGTGAAAATGACTTGACAGTT
    AACATCACGAAGGCAAAACAAATGACCAACGTTCGTTCAGCTACTAAGGACCAAACAGCT
    GTTATCAAGACGCCTCGTATCTTGACACTTGAAGAGTCTCTTGAGTTCTTGAACGACGAT
    GAGTACATGGAAGTAACGCCTGAGTCTATCCGTTTGCGTAAACAAATCCTTAACAAAGCA
    GAGCGTGAGAAAGCTAACAAGAAGAAAAAATCAGCTGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1842

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: BMJ42_RS03935 [old locus tag: BMJ42_00730 ]
  • symbol: TypA
  • description: translational GTPase TypA
  • length: 613
  • theoretical pI: 4.53014
  • theoretical MW: 68183
  • GRAVY: -0.288254

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 975.4)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 975.4)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 975.4)
    and 15 more
    Genetic information processing Protein synthesis Translation factors translation elongation factor G (TIGR00484; HMM-score: 215.6)
    Genetic information processing Protein synthesis Translation factors translation elongation factor aEF-2 (TIGR00490; HMM-score: 207.1)
    Unknown function General elongation factor 4 (TIGR01393; EC 3.6.5.-; HMM-score: 205.6)
    Genetic information processing Protein synthesis Translation factors translation elongation factor Tu (TIGR00485; HMM-score: 98.6)
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 3 (TIGR00503; HMM-score: 95.8)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 83)
    Genetic information processing Protein synthesis Translation factors translation elongation factor EF-1, subunit alpha (TIGR00483; HMM-score: 72.4)
    Genetic information processing Protein synthesis Translation factors selenocysteine-specific translation elongation factor (TIGR00475; HMM-score: 68.3)
    Genetic information processing Protein synthesis Translation factors translation initiation factor IF-2 (TIGR00487; HMM-score: 65.6)
    Metabolism Central intermediary metabolism Sulfur metabolism sulfate adenylyltransferase, large subunit (TIGR02034; EC 2.7.7.4; HMM-score: 49.5)
    Genetic information processing Protein synthesis Translation factors translation initiation factor aIF-2 (TIGR00491; HMM-score: 39.2)
    translation initiation factor 2, gamma subunit (TIGR03680; HMM-score: 31.3)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 24.3)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 14.5)
    exopolysaccharide/PEP-CTERM locus tyrosine autokinase (TIGR03018; EC 2.7.10.2; HMM-score: 13.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 184.4)
    and 11 more
    EF-G_C (CL0437) EFG_C; Elongation factor G C-terminus (PF00679; HMM-score: 85.7)
    EFTPs (CL0575) GTP_EFTU_D2; Elongation factor Tu domain 2 (PF03144; HMM-score: 52)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 30.8)
    EF-G_C (CL0437) EFG_III; Elongation Factor G, domain III (PF14492; HMM-score: 26.7)
    P-loop_NTPase (CL0023) Arf; ADP-ribosylation factor family (PF00025; HMM-score: 20.1)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 18.6)
    Septin; Septin (PF00735; HMM-score: 17.8)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 14.9)
    AIG1; AIG1 family (PF04548; HMM-score: 14.8)
    Dynamin_N; Dynamin family (PF00350; HMM-score: 13.3)
    no clan defined GTP_EFTU_D4; Elongation factor Tu domain 4 (PF14578; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.996
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0036
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004062
    • TAT(Tat/SPI): 0.000419
    • LIPO(Sec/SPII): 0.000523
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000164111 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAERAMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQLDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSRKVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPARGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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