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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 08-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SP49
  • locus tag: BMJ42_RS12190 [old locus tag: BMJ42_02316 ]
  • pan locus tag?: PNEUPAN003949000
  • symbol: BMJ42_RS12190
  • pan gene symbol?: htrA
  • synonym:
  • product: S1C family serine protease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: BMJ42_RS12190 [old locus tag: BMJ42_02316 ]
  • symbol: BMJ42_RS12190
  • product: S1C family serine protease
  • replicon: chromosome
  • strand: +
  • coordinates: 2204435..2205616
  • length: 1182
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP018136 (2204435..2205616) NCBI
  • BioCyc: BMJ42_RS12190 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2068 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATT
    AGCTTTTTTAGTGGAGCCTTGGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGT
    GTAAACAACTCTAACAACAATAGTACTATTACACAAACTGCCTATAAGAACGAAAATTCA
    ACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
    AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCT
    AGTGAAGGATCTGGAGTTATTTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAAC
    AATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGATTGTCAGATGGGACTAAAGTA
    CCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
    GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACT
    GCTATTGCCATCGGTAGCCCGTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATC
    GTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAGATGGACAAGCTATTTCTACA
    AAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
    ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCT
    GTAGAAGGTCTTGGTTTCGCAATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTA
    GAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCCAGATGGTTAATTTATCTAAT
    GTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
    GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATT
    ACAAAAGTAGATGACAAAGAGATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAAC
    CATTCTATCGGAGACACCATTAAGATAACCTACTATCGTAACGGGAAAGAAGAAACTACC
    TCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1182

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: BMJ42_RS12190 [old locus tag: BMJ42_02316 ]
  • symbol: BMJ42_RS12190
  • description: S1C family serine protease
  • length: 393
  • theoretical pI: 6.98004
  • theoretical MW: 41855.4
  • GRAVY: -0.260305

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.21.-?  ExPASy
  • TIGRFAM:
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 275.3)
    Genetic information processing Protein fate Protein folding and stabilization peptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 275.3)
    and 5 more
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides periplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 178.7)
    Signal transduction Regulatory functions Protein interactions periplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 178.7)
    Signal transduction Regulatory functions Other RNA chaperone Hfq (TIGR02383; HMM-score: 14.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides RIP metalloprotease RseP (TIGR00054; EC 3.4.24.-; HMM-score: 13.6)
    GLPGLI family protein (TIGR01200; HMM-score: 6)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Peptidase_PA (CL0124) Trypsin_2; Trypsin-like peptidase domain (PF13365; HMM-score: 106)
    PDZ-like (CL0466) PDZ_2; PDZ domain (PF13180; HMM-score: 90.3)
    and 6 more
    Peptidase_PA (CL0124) Trypsin; Trypsin (PF00089; HMM-score: 59.3)
    Peptidase_MA (CL0126) Peptidase_M50; Peptidase family M50 (PF02163; HMM-score: 27.4)
    PDZ-like (CL0466) PDZ; PDZ domain (PF00595; HMM-score: 21.2)
    Peptidase_PA (CL0124) Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease (PF00949; HMM-score: 15)
    PDZ-like (CL0466) PDZ_6; PDZ domain (PF17820; HMM-score: 14.1)
    no clan defined FPP; Filament-like plant protein, long coiled-coil (PF05911; HMM-score: 10.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0006
    • Cytoplasmic Membrane Score: 0.8191
    • Cell wall & surface Score: 0.0125
    • Extracellular Score: 0.1678
  • SignalP: Signal peptide SP(Sec/SPI) length 31 aa
    • SP(Sec/SPI): 0.773697
    • TAT(Tat/SPI): 0.010815
    • LIPO(Sec/SPII): 0.170382
    • Cleavage Site: CS pos: 31-32. SFS-IT. Pr: 0.1057
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000681601 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISSEKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Yasser Musa Ibrahim, Alison R Kerr, Jackie McCluskey, Tim J Mitchell
Role of HtrA in the virulence and competence of Streptococcus pneumoniae.
Infect Immun: 2004, 72(6);3584-91
[PubMed:15155668] [WorldCat.org] [DOI] (P p)Marco Cassone, Alyssa L Gagne, Lynn A Spruce, Steven H Seeholzer, Michael E Sebert
The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.
J Biol Chem: 2012, 287(46);38449-59
[PubMed:23012372] [WorldCat.org] [DOI] (I p)Sacha F de Stoppelaar, Hester J Bootsma, Aldert Zomer, Joris J T H Roelofs, Peter W M Hermans, Cornelis van 't Veer, Tom van der Poll
Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia.
PLoS One: 2013, 8(11);e80062
[PubMed:24244609] [WorldCat.org] [DOI] (I e)

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