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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-DEC-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Xen35
  • locus tag: CXP32_01570 [new locus tag: CXP32_RS01570 ]
  • pan locus tag?: PNEUPAN001105000
  • symbol: CXP32_01570
  • pan gene symbol?: spnHL
  • synonym:
  • product: hyaluronate lyase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: CXP32_01570 [new locus tag: CXP32_RS01570 ]
  • symbol: CXP32_01570
  • product: hyaluronate lyase
  • replicon: chromosome
  • strand: +
  • coordinates: 287449..290682
  • length: 3234
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP025256 (287449..290682) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0287 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    TTGATTTTACAATATGTTTATTGGAGTGTATACATGCAAACAAAAACAAAGAAGCTCATT
    GTGAGTTTGTCTTCACTTGTTTTATCAGGATTTTTATTAAACCATTATATGACAATTGGA
    GCGGAAGAAACGACTACGAATACCATTCAGCAAAGCCAGAAGGAAGTTCAGTATCAGCAA
    AGGGATACAAAAAATTTAGTTGAAAATGGTGATTTTGGTCAGACGGAGGACGGAAGCAGT
    CCGTGGACAGGAAGCAAAGCTCAGGGGTGGTCAGCTTGGGTAGACCAGAAGAATAGTGCA
    GATGCCTCAACTCGAGTCATTGAGGCTAAGGATGGGGCTATCACTATCTCAAGCCATGAG
    AAATTAAGGGCAGCGCTTCACCGTATGGTTCCTATTGAAGCTAAGAAAAAGTATAAACTG
    CGTTTCAAGATTAAAACAGATAATAAAATCGGGATTGCCAAAGTTCGTATCATTGAGGAA
    AGTGGTAAGGACAAGCGATTGTGGAATTCTGCAACGACGTCAGGAACAAAGGACTGGCAG
    ACCATTGAAGCAGACTATAGCCCGACTTTAGATGTTGATAAAATCAAGCTGGAGTTATTC
    TATGAAACAGGAACTGGGACTGTTTCCTTTAAGGATATTGAGCTGGTAGAGGTAGCAGAC
    CAGCTTTCTGAGGATTCTCAAACAGATAAACAGCTTGAGGAAAAGATTGATTTACCAATT
    GGAAAAAAACATGTTTTTTCTCTTGCGGACTATACTTATAAGGTAGAAAATCCTGACGTT
    GCTTCAGTCAAAAATGGAATTTTAGAACCTCTTAAGGAAGGGACAACCAATGTCATTGTC
    AGTAAAGATGGCAAGGAAGTGAAAAAGATTCCTTTGAAGATTCTGGCCTCTGTTAAGGAT
    GCATACACAGACCGTTTGGATGACTGGAATGGCATCATCGCTGGGAATCAATACTATGAT
    TCTAAAAATGAACAGATGGCCAAATTAAACCAGGAATTGGAAGGAAAGGTAGCTGATAGC
    CTATCCAGTATTTCAAGTCAGGCGGACCGCACCTATTTGTGGGAAAAATTTTCAAATTAT
    AAAACGTCTGCAAATCTGACTGCCACTTATCGGAAATTGGAGGAGATGGCCAAGCAAGTG
    ACCAATCCTTCTTCTCGTTATTATCAAGATGAAACTGTCGTTCGAACAGTCAGGGATTCC
    ATGGAATGGATGCATAAACATGTCTACAATAGTGAAAAGAGCATTGTTGGGAACTGGTGG
    GATTATGAAATCGGTACACCTCGTGCCATCAACAATACCTTGTCTCTGATGAAAGAATAC
    TTCTCTGATGAGGAAATTAAAAAATATACAGATGTGATTGAAAAATTTGTACCAGATCCC
    GAACATTTCCGAAAGACGACTGATAACCCATTCAAGGCTCTAGGTGGAAACTTAGTTGAT
    ATGGGAAGGGTAAAAGTAATAGCTGGTTTACTGCGTAAGGATGATCAAGAAATTTCTTCT
    ACCATTCGCTCGATTGAGCAAGTGTTCAAGTTGGTAGACCAAGGTGAAGGTTTTTATCAA
    GATGGATCCTATATCGACCACACCAATGTTGCCTATACGGGTGCTTATGGGAATGTTTTG
    ATTGATGGCCTGTCTCAACTGTTGCCAGTCATTCAAAAGACCAAGAATCCAATCGATAAA
    GATAAAATGCAAACCATGTACCACTGGATTGATAAATCGTTTGCTCCTTTGCTGGTGAAT
    GGAGAGTTGATGGATATGAGTCGTGGACGCTCGATCAGTCGTGCAAATAGCGAGGGGCAC
    GTGGCCGCAGTAGAAGTACTAAGAGGGATTCACCGAATAGCGGATATGTCTGAAGGAGAA
    ACCAAACAATGTTTGCAGAGTCTTGTGAAGACCATTGTTCAATCGGATAGTTATTATGAT
    GTCTTTAAGAATTTGAAGACTTATAAGGATATCAGTTTGATGCAATCCTTGTTAAGTGAT
    GCAGGAGTCGCAAGTGTTCCAAGACCAAGTTACCTATCTGCCTTTAACAAGATGGATAAA
    ACAGCCATGTACAATGCAGAGAAAGGGTTTGGATTTGGCTTGTCACTCTTTTCCAGTCGT
    ACCTTGAATTACGAACACATGAACAAGGAAAATAAACGTGGTTGGTATACGAGTGATGGG
    ATGTTCTATCTTTACAATGGCGATTTGAGTCACTATAGCGATGGCTACTGGCCAACAGTT
    AATCCATATAAGATGCCTGGTACAACAGAGACGGATGCTAAGAGAGCGGATAGCGATACA
    GGTAAAGTTTTACCGTCTGCTTTCGTTGGAACGAGCAAACTAGATGATGCCAATGCGACA
    GCAACCATGGATTTCACCAACTGGAATCAAACATTGACTGCTCATAAGAGCTGGTTTATG
    CTAAAGGATAAGATCGCCTTTTTAGGAAGCAATATCCAAAACACTTCAACAGATACTGCT
    GCAACTACAATTGACCAGAGAAAACTGGAATCAGGTAATCCATATAAAGTCTATGTCAAT
    GATAAAGAAGCCTCCCTTACAGAACAAGAAAAGGATTATCCTGAAACCCAAAGTGTCTTT
    TTAGAATCGTTCGATTCGAAAAAGAATATTGGTTACTTTTTCTTTAAGAAGAGTTCAATC
    AGTATGAGTAAGGCTTTGCAAAAGGGAGCCTGGAAGGATATCAATGAAGGACAGTCAGAC
    AAGGAAGTTGAAAATGAATTTCTTACGATTAGTCAGGCTCATAAGCAAAATAGAGATTCT
    TATGGCTATATGCTCATTCCTAACGTGGATCGTGCCACCTTCAATCAAATGATAAAAGAG
    TTAGAAAGTAGCCTCATCGAAAATAACGAAACCCTTCAGTCTGTTTATGATGCTAAACAA
    GGAGTTTGGGGCATTGTGAAATATGATGATTCTGTCTCTACTATTTCCAACCAATTCCAA
    GTTTTGAAACGTGGAGTCTATACCATTCGAAAAGAAGGGGATGAATATAAGATTGCCTAC
    TATAATCCTGAAACCCAGGAATCAGCTCCAGATCAGGAAGTCTTTAAAAAGCTAGAGCAA
    GCAGCTCAGCCACAAGTACAGAATTCAAAAGAAAAGGAAAAATCTGAAGAGGAAAAGAAC
    CATTCGGATCAAAAGAATCTCCCTCAGACAGGAGAAGGTCAGTCAATCTTGGCAAGTCTA
    GGGTTCTTGCTACTTGGGGCATTTTATCTATTCCGTAGAGGAAAGAACAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
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    720
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    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3234

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: CXP32_01570 [new locus tag: CXP32_RS01570 ]
  • symbol: CXP32_01570
  • description: hyaluronate lyase
  • length: 1077
  • theoretical pI: 5.96873
  • theoretical MW: 122217
  • GRAVY: -0.655432

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Hy-ly_N (CL0372) Lyase_8_N; Polysaccharide lyase family 8, N terminal alpha-helical domain (PF08124; HMM-score: 432.3)
    and 4 more
    Gal_mutarotase (CL0103) Lyase_8; Polysaccharide lyase family 8, super-sandwich domain (PF02278; HMM-score: 230.2)
    no clan defined Lyase_8_C; Polysaccharide lyase family 8, C-terminal beta-sandwich domain (PF02884; HMM-score: 45.8)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 18.4)
    DUF4449; Protein of unknown function (DUF4449) (PF14613; HMM-score: 16.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 9.49
    • Extracellular Score: 0.5
    • Internal Helices: 2
  • SignalP: Signal peptide SP(Sec/SPI) length 41 aa
    • SP(Sec/SPI): 0.711589
    • TAT(Tat/SPI): 0.002674
    • LIPO(Sec/SPII): 0.008358
    • Cleavage Site: CS pos: 41-42. IGA-EE. Pr: 0.5559
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AUF84202 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MILQYVYWSVYMQTKTKKLIVSLSSLVLSGFLLNHYMTIGAEETTTNTIQQSQKEVQYQQRDTKNLVENGDFGQTEDGSSPWTGSKAQGWSAWVDQKNSADASTRVIEAKDGAITISSHEKLRAALHRMVPIEAKKKYKLRFKIKTDNKIGIAKVRIIEESGKDKRLWNSATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQLSEDSQTDKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKEVKKIPLKILASVKDAYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSISSQADRTYLWEKFSNYKTSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSMEWMHKHVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDPEHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGFYQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAPLLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQCLQSLVKTIVQSDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRPSYLSAFNKMDKTAMYNAEKGFGFGLSLFSSRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTETDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFLGSNIQNTSTDTAATTIDQRKLESGNPYKVYVNDKEASLTEQEKDYPETQSVFLESFDSKKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNRDSYGYMLIPNVDRATFNQMIKELESSLIENNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVLKRGVYTIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQAAQPQVQNSKEKEKSEEEKNHSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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