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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS04735 [old locus tag: NCTC7466_00910 ]
  • pan locus tag?: PNEUPAN001993000
  • symbol: DQM66_RS04735
  • pan gene symbol?: dnaQ
  • synonym:
  • product: 3'-5' exonuclease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS04735 [old locus tag: NCTC7466_00910 ]
  • symbol: DQM66_RS04735
  • product: 3'-5' exonuclease
  • replicon: chromosome
  • strand: +
  • coordinates: 891990..892580
  • length: 591
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (891990..892580) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0879 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGGAACGATTAGAAGATTACATTGCTTTTGATTTAGAATTTAATCAGCACGAAGGACAA
    ACACACTTGATTCAAGTATCGGCAGTGCGTTTTAGAGATGGTCGGGAAATCGATGCCTAT
    GATTCCTATGTTCATACCAGCGTCCCTCTAAAAAGCTTTATCAATGGTTTGACCGGGATT
    ACAGCTGAGACCTTAAAAGATGCTCCTCCAGTTGAGAAAGTCTTAGAAGAATTCCAAGAG
    TTTGTGGGTTCTTTGCTGATGATAGGCTACAATGCTGCTAAAAGTGATTTACCTATTTTA
    GCAGAGCATGGTTTAGACTATAGCCAACAGTACAAGGTGGATTTGTATGATGAAGCTTTT
    GAACGTCGGAGTTCAGATTTACATGGTATTGCCAATCTCAAATTGCAAACTGTTGCCTCA
    TTTCTTGGATTTCAAGGTCAGTCTCATAATAGTTTAGAGGATGCTCGGATGACGGCGCGT
    GTTTACGAATCCTTCTTAGAGTCGGATCAAGCTAGGGAATTGTTAGAGACAGAAAGTAGC
    TTATCAAACAATCCTTTTGGTGGCTTGGACTTGTCTCAATTATTTGACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    591

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS04735 [old locus tag: NCTC7466_00910 ]
  • symbol: DQM66_RS04735
  • description: 3'-5' exonuclease
  • length: 196
  • theoretical pI: 4.2314
  • theoretical MW: 22135.4
  • GRAVY: -0.361225

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, alpha subunit, Gram-positive type (TIGR01405; EC 2.7.7.7; HMM-score: 61.6)
    and 3 more
    Genetic information processing DNA metabolism Degradation of DNA exonuclease, DNA polymerase III, epsilon subunit family (TIGR00573; EC 2.7.7.7; HMM-score: 48.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DnaQ family exonuclease/DinG family helicase (TIGR01407; HMM-score: 43)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, epsilon subunit (TIGR01406; EC 2.7.7.7; HMM-score: 27)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    RNase_H (CL0219) RNase_T; Exonuclease (PF00929; HMM-score: 55.2)
    and 2 more
    Rv2179c-like; 3'-5' exoribonuclease Rv2179c-like domain (PF16473; HMM-score: 29.2)
    RNase_H_2; RNase_H superfamily (PF13482; HMM-score: 23.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.982
    • Cytoplasmic Membrane Score: 0.0013
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0165
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003633
    • TAT(Tat/SPI): 0.000755
    • LIPO(Sec/SPII): 0.000349
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000440254 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MERLEDYIAFDLEFNQHEGQTHLIQVSAVRFRDGREIDAYDSYVHTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAEHGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTARVYESFLESDQARELLETESSLSNNPFGGLDLSQLFD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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