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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 12-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS07645 [old locus tag: NCTC7466_01473 ]
  • pan locus tag?: PNEUPAN003035000
  • symbol: DQM66_RS07645
  • pan gene symbol?: —
  • synonym:
  • product: NAD(P)-dependent oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS07645 [old locus tag: NCTC7466_01473 ]
  • symbol: DQM66_RS07645
  • product: NAD(P)-dependent oxidoreductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1457988..1458617
  • length: 630
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (1457988..1458617) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1440 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAACTAGCAGTTATTGCAGCAAATGGACAAGTGGGGAAAGCAATTGTTGAAGAAGCA
    GTCAAACGAGGACATGAAGTAACGGCTATTGTTCGTTCTGAAAACAAAAGTCAAGCTGAG
    TCTATTATTAAAAAAGATTTATTTGAGTTGACAAAAGATGATCTTACTGGATTTGATGCT
    GTTATTTCAGCGTTTGGTGCTTATACACCAGATACGCTACCGCTCCATAGCAAATCAATT
    GAACTATTTAATCAGCTTCTTGCTGGAACACAGACACGTTTTCTAGTTGTAGGGGGAGCA
    GGAAGTCTTTATATAGATGAAACAAAAACGACACGACTTTTAGATACGCCTGATTTTCCT
    GAAGAATTTAAGTCACTAGCAAAAGCTCAAGCGGATGAATTGGATCTTCTTCGTACAAAA
    AATAATCTCAACTGGACTTTTGTCAGTCCTGCTGTAGATTTTATTCCCGATGGTGAAAAA
    ACAGGAAACTACATTCTAGCAGGAGAAATTTTTACTACTAATGAAAAAGGAATAAGCCAG
    ATTAGTTATGCAGATTATGCTATTGGATTGGTAGATGAACTTGAAAAAGGTCATCATATA
    AAAGAACGTATCTCTTTACTTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    630

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS07645 [old locus tag: NCTC7466_01473 ]
  • symbol: DQM66_RS07645
  • description: NAD(P)-dependent oxidoreductase
  • length: 209
  • theoretical pI: 4.75211
  • theoretical MW: 22958.9
  • GRAVY: -0.177033

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.-?  ExPASy
  • TIGRFAM:
    Hypothetical proteins Conserved TIGR01777 family protein (TIGR01777; HMM-score: 23.9)
    and 3 more
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 13.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A phosphopantothenate--cysteine ligase (TIGR02114; EC 6.3.2.5; HMM-score: 13)
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 11.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 67.4)
    and 8 more
    NmrA; NmrA-like family (PF05368; HMM-score: 27.9)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 24.4)
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase (PF16363; HMM-score: 18.8)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 18.5)
    RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 15.8)
    PreATP-grasp (CL0483) Rimk_N; RimK PreATP-grasp domain (PF18030; HMM-score: 15.2)
    NADP_Rossmann (CL0063) DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 14.5)
    LpxI_N; LpxI N-terminal domain (PF17930; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9715
    • Cytoplasmic Membrane Score: 0.0035
    • Cell wall & surface Score: 0.0045
    • Extracellular Score: 0.0206
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012512
    • TAT(Tat/SPI): 0.000421
    • LIPO(Sec/SPII): 0.001543
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000762101 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLAVIAANGQVGKAIVEEAVKRGHEVTAIVRSENKSQAESIIKKDLFELTKDDLTGFDAVISAFGAYTPDTLPLHSKSIELFNQLLAGTQTRFLVVGGAGSLYIDETKTTRLLDTPDFPEEFKSLAKAQADELDLLRTKNNLNWTFVSPAVDFIPDGEKTGNYILAGEIFTTNEKGISQISYADYAIGLVDELEKGHHIKERISLLEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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