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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NCTC7466
  • locus tag: DQM66_RS08875 [old locus tag: NCTC7466_01703 ]
  • pan locus tag?: PNEUPAN003378000
  • symbol: treR
  • pan gene symbol?: treR
  • synonym:
  • product: trehalose operon repressor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: DQM66_RS08875 [old locus tag: NCTC7466_01703 ]
  • symbol: treR
  • product: trehalose operon repressor
  • replicon: chromosome
  • strand: +
  • coordinates: 1678234..1678944
  • length: 711
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_LS483374 (1678234..1678944) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1665 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAGAAATACCAACAATTATTTAAGCAAATCCAAGAAACCATTCAAAACGAGACTTAC
    GCTGTCGGAGATTTTCTTCCTAGCGAGCACGACCTTATGGAGCAATATCAAGTGAGTCGT
    GATACCGTCCGAAAGGCCCTGTCTCTCCTCCAAGAGGAAGGATTGATCAAAAAGATAAGA
    GGGCAAGGTTCTCAAGTCGTCAAAGAAGAAACCGTCAATTTCCCTGTATCCAACCTAACC
    AGCTACCAAGAACTAGTTAAAGAACTTGGACTGCGCTCTAAAACCAACGTGGTCAGTCTG
    GACAAGATTATTATTGATAAAAAATCCTCACTGATAACCGGTTTCCCAGAGTTTCGGATG
    GTTTGGAAGGTGGTCCGCCAGCGTGTGGTGGATGATCTGGTATCCGTTCTGGATACGGAC
    TATCTGGATATGGAACTAATCCCAAATCTCACTCGCCAAATCGCTGAGCAGTCTATCTAT
    TCTTATATAGAAAATGGCCTCAAACTCCTTATTGATTATGCTCAGAAGGAAATCACCATT
    GACCACTCAAGCGACCGAGACAAGATTCTCATGGACATTGGCAAAGACCCTTATGTCGTT
    TCGATTAAATCAAAAGTCTATCTCCAAGACGGACGCCAATTTCAGTTTACCGAAAGTCGC
    CATAAGTTAGAAAAATTTAGATTTGTAGATTTTGCAAAACGCAAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    711

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: DQM66_RS08875 [old locus tag: NCTC7466_01703 ]
  • symbol: TreR
  • description: trehalose operon repressor
  • length: 236
  • theoretical pI: 9.0589
  • theoretical MW: 27607.6
  • GRAVY: -0.461441

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02404; HMM-score: 290.5)
    and 11 more
    Signal transduction Regulatory functions DNA interactions phosphonate utilization transcriptional regulator PhnR (TIGR03337; HMM-score: 71.6)
    Metabolism Energy metabolism Amino acids and amines histidine utilization repressor (TIGR02018; HMM-score: 69)
    Signal transduction Regulatory functions DNA interactions histidine utilization repressor (TIGR02018; HMM-score: 69)
    Metabolism Transport and binding proteins Anions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 69)
    Signal transduction Regulatory functions DNA interactions phosphonate metabolism transcriptional regulator PhnF (TIGR02325; HMM-score: 69)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 23.9)
    Metabolism Fatty acid and phospholipid metabolism Degradation fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 23.9)
    Signal transduction Regulatory functions DNA interactions fatty acid metabolism transcriptional regulator FadR (TIGR02812; HMM-score: 23.9)
    phosphonate utilization associated transcriptional regulator (TIGR03338; HMM-score: 21.6)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions putative phage terminase, small subunit, P27 family (TIGR01558; HMM-score: 14)
    Signal transduction Regulatory functions DNA interactions biotin operon repressor (TIGR00122; HMM-score: 13)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    UTRA (CL0122) UTRA; UTRA domain (PF07702; HMM-score: 92.8)
    and 14 more
    HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 60.9)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 26.2)
    HTH_11; HTH domain (PF08279; HMM-score: 21.7)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 17.7)
    HTH_41; Helix-turn-helix domain (PF14502; HMM-score: 17.3)
    Rrf2; Iron-dependent Transcriptional regulator (PF02082; HMM-score: 17.2)
    HTH_29; Winged helix-turn helix (PF13551; HMM-score: 16.4)
    HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 15.8)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 15.6)
    TFIIE_alpha; TFIIE alpha subunit (PF02002; HMM-score: 13.7)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 13.3)
    DUF4423; Domain of unknown function (DUF4423) (PF14394; HMM-score: 13)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 12.1)
    UPF0122; Putative helix-turn-helix protein, YlxM / p13 like (PF04297; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by TreR, TF important in Trehalose utilization: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001981
    • TAT(Tat/SPI): 0.000406
    • LIPO(Sec/SPII): 0.000245
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000760673 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVRKALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDKIIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIYSYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTESRHKLEKFRFVDFAKRKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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