PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 06-JAN-2021

⊟Summary

• organism: Streptococcus pneumoniae EF3030
• locus tag: EF3030_RS00880 [old locus tag: EF3030_00880 ]
• pan locus tag^?: PNEUPAN000884000
• symbol: EF3030_RS00880
• pan gene symbol^?: —
• synonym:
• product: divalent metal cation transporter

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EF3030_RS00880 [old locus tag: EF3030_00880 ]
• symbol: EF3030_RS00880
• product: divalent metal cation transporter
• replicon: chromosome
• strand: -
• coordinates: 161591..162853
• length: 1263
• essential: unknown

⊟Accession numbers

• Location: NZ_CP035897 (161591..162853) NCBI
• BioCyc: EF3030_RS00880 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0161 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  
  ATGTCGCAAGCTATTTCCTTAAATCAATCAACCTGGGCAAGCAAGCTAAAAGCAATGGGA
  CCTGGAATCCTAATGGCAACTGCCGCTGTTGGAGGTTCCCACATTGTATCCTCAACTCAA
  GCTGGCGGTTCTTACGGTTGGTCTCTACTTCTCTTGGTCATCTTAGCCAATGTCTTTAAA
  TATCCATTTTTCCGTTTTGGTGCTGAATACACAGCTGATACTGGAAAGACTTTGGTTGAA
  GGTTATGCCGAAAAAGGAAAACTCTATCTCTGGATTTTCTTTATTCTCAATGTCTTTTCG
  GCTATGGTCAACACGGCTGGTGTTGCCATTCTGTGCTCAGCTATCATCGCCAGTGCCTTC
  CCAATGATTGGACTTAGCATTACTCAGTGGTCCCTCATTCTCGTTGCAATCATTTGGGCT
  ATGCTACTCTTTGGAGGCTACAAACTTTTAGACGGCATGGTCAAATGGATTATGTCTGCC
  TTAACCATTGCGACTGTTCTTGCAGTTATCATTGCGGCGGTCAAGCATCCAGAATACAGT
  TCTGATTTTGTCGAGAAGACACCTTGGCAAATGGCAGCTCTGCCCTTCATCGTCTCCCTC
  CTAGGATGGATGCCGGCTCCTATTGAAATTTCAGCCATCAATTCACTTTGGTCAGCTGAA
  AAGAGAAAGACCGTCAACTTTAACACAGAAGACGCTCTGTTTGACTTTAACACTGGTTAT
  ATTGGAACAGCTATCCTAGCCGTCTTCTTTGTGGCACTGGGAGCACTGATTCAGTATCCT
  ACAGGGCAGGCGGTTGAAGCTGCTTCAGCCAAATACATCTCTCAATTCGTGGGCATGTAT
  GCCTCTGTTCTTGGCGAATGGTCCCGTTACTTGATTACCTTTATTGCCTTCCTCTGTATC
  TTTGGAACAGTTATAACTGTTATCGATGGCTATTCTCGCGTTAATCAGGAATCTCTCCGA
  CTGCTAATCAGTCAAAAAGAGGACAATCGTAAATCTTTGAACATCTGGATGACCATCACT
  GCTATCATCGGTATCGTCATTATCAAGTTCTTCGCTGGTCAGGTTTCAACCATGCTCCGC
  TTTGCCATGATTGGATCTTTCCTGACAACACCTTTCTTTGCTCTTTTGAATTACGCCTTG
  GTAACGCGTGAAAACAAAAATCTTCCTTCTTGGCTCAAACACCTTGCCATTGCGGGATTG
  ATTTTCCTCTTTGGCTTCGCCATCTTCTTTATCTACGCACTCGCAATCGGAAAAGCAGGG
  TAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1263
  

⊟Protein

⊟General

• locus tag: EF3030_RS00880 [old locus tag: EF3030_00880 ]
• symbol: EF3030_RS00880
• description: divalent metal cation transporter
• length: 420
• theoretical pI: 9.54404
• theoretical MW: 45926.1
• GRAVY: 0.779762

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Cations and iron carrying compounds metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family (TIGR01197; HMM-score: 21.9)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  APC (CL0062) Nramp; Natural resistance-associated macrophage protein (PF01566; HMM-score: 39.1)
  and 3 more
  AA_permease_2; Amino acid permease (PF13520; HMM-score: 20.2)
  no clan defined Wzz; Chain length determinant protein (PF02706; HMM-score: 12.7)
  YobH; YobH-like protein (PF13996; HMM-score: 10.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 10
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 11
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.079229
  • TAT(Tat/SPI): 0.024126
  • LIPO(Sec/SPII): 0.0715
• predicted transmembrane helices (TMHMM): 11

⊟Accession numbers

• GI:
• RefSeq: WP_000075789 NCBI
• UniProt:

⊟Protein sequence

• MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGSYGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKLYLWIFFILNVFSAMVNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSALTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWSAEKRKTVNFNTEDALFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQFVGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLNIWMTITAIIGIVIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWLKHLAIAGLIFLFGFAIFFIYALAIGKAG

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_0161 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications