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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 49619
  • locus tag: EL263_RS03280 [old locus tag: SPAT_0612 ]
  • pan locus tag?: PNEUPAN001606000
  • symbol: EL263_RS03280
  • pan gene symbol?: zmpB
  • synonym:
  • product: G5 domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EL263_RS03280 [old locus tag: SPAT_0612 ]
  • symbol: EL263_RS03280
  • product: G5 domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 619870..625575
  • length: 5706
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_AP018938 (619870..625575) NCBI
  • BioCyc: EL263_RS03280 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0577 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
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    3721
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    3841
    3901
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    4021
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    4141
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    4261
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    4441
    4501
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    4621
    4681
    4741
    4801
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    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    5641
    5701
    GTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTT
    CTTGGAAGCCTTTTGATGGCTCCTTCTGTAGTGGACGCAGCTACCTATCACTATGTAAAT
    AAAGAGATTATTTCACAAGAAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAAT
    GAAGTTGTATATGGTTTGGTGTATCAAAAAGATCAGTTGCCTCAAACAGGGACAGAAGCA
    TCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGCTTGCTTTTAATCTACAAGAGA
    AAGAAAATTGCTAGCGTATTTCTAGTTGGAGCTATGGGATTGGTAGTTCTTCCTAGTGCA
    GGGGCTGTAGACCCAGTTGCGACCCTAGCACTGGCTAGTCGAGAGGGTGTTGTTGAAATG
    GAGGGCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGAC
    ACTGTTTTAGAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACT
    CCTCAATCAACAACAAATCAGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAG
    GAAGCTCCAAAAGAAGAAGCACCTAAAACAGAAGAAAGTCCAAAGGAAGAACCAAAATCG
    GAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGGGAAAGAAGATTCAGTA
    GAATCAGCTCCAGTTGAAGAAGTAAGTGGAGAAGTTGAGTCAAAACCAGAGGAAAAAGTA
    GCAGTTAAGCCAGAAAGTCAACCATCAGATAAACAAGCTGAGGAGCCAAACGTTGAACCA
    CCAGTAGAACAACCAAAAGTCCCAGAACAACCCGTGCAACCTACACAAGCTGAGCAACCA
    AGGATACCAAAAGATTCATCACAAGAAGACAATCCTAAAGAAGATAGGGGAGCGGAAGAG
    ACACCGAAACAAGAAGATACACAGCCAGCAGAAGCCCCAGAAATCAAGGTTGAAGAACCA
    GTAGAATCAAAAGAGGAGACTAAAACAGCTAAGGGGACGCAAGAAGAAGATTACGTGGGT
    GAGGCTCTTGTTCCAGAACAATTACCTGAGTATAAGGTGACTGAAGGAACACTCGTTGAA
    GAATCAACTACAGAACTTGACTATAAAACTGAAACGACTGAGGACCCAACCAAGTACACG
    GACGAAGAAACTGTCCTACGAAATGGTGAAAAAGGAAGTCAAGTTACAAAAACAACCTAT
    AAAACAATAGGAGGGGTTAAAACTGACCAAGTTCTTTCAACCAGTACGGAAGTCACCAAG
    GAGCCTGTAAATCAACAGGTAATCCGTGGTACAAAACCAATTGAAGGGACAACGGTTGAG
    ACAAGAGAAGAAATCATTTCTTTTGAAACAAAAGAACAAGAAGATGACACTTTAAAACGC
    GGAACAAGACAAGTAACTCAAGAAGGTGTAAACGATAAGAAACAAATTACTGAAACCTAT
    AAAACAATTCGCGGAGAAAAAACAAGTGACGCTCCTACTATCACAGAAACAGTGATTGAA
    AAACCTCAAGACAAAATTATTAAGAATGGCACAAAAGAGTTAGAGAAACCAACCTTGGAA
    TGGGCTAAAACAGATAAAGATGTCTTGAAGAAGAGTGCGACAGCTAGTTATACATTGACT
    AAACCAGCTGGAGTAGAAATTAAATCGATTAAAGTAGCTCTAAAAGATAATACTGGAACA
    GTTGTTAAAGAAGTAACGGTAGAAGAAAATAACTTACAAGCTACTTTAGATAAATTGAAA
    TATTATCAAGGTTACACCCTATCTACTACAATGGTTTATGATCGTGGAGAAGGTGAAGAA
    ACTGAGAAATTAGAAGATAAACAAATTCAATTAGACCTTAAAAAAGTTGAAATCAAAAAC
    ATTAAAGAAACAAGCTTAATGAATGTTGATGCTGAGGGTAACGAAACTGATAAGAGCTTA
    TTATCTGAAAAACCGACAGATGTTTCCCAATTGTATTTACGTGTGACAACTCATGACAAC
    AAAGTGACAAGACTTGCGGTAAGTTCAGTTGAAGAAGTTGTTGTTGATGGAAAAACATTG
    TACAAAGTTGTAGCCAAAGCTCCAGACTTAGTTCAACGTAGAGCTGATGATACACTGAGT
    GAAGAATATGTTCATTATTTTGAAAAACAATTACCAAAAGTAAATAATGTATACTACAAC
    TTCAATGAACTTGTAAAAGATATGCAAGCTAATCCAACGGGTGAGTTTAAACTTGGTGCA
    GACTTGAATGCAGCAAATGTAAAACCTAACGGGAAATCTTATGTAACGAAACCATTTAAA
    GGGAAATTACTAAGTAATGACGGCGGTAGATTTACAATCCATAATATAGAACGTCCATTA
    TTCGCTAATATTGAAGGTGGTAAAATCCACGATATTAATCTTGCTAATGTAAATATTAAT
    ATGCCTTGGGCTGATAAAGTTGCTCCTATTGCAAATGTAATCAAAAATAATGCAACCATT
    GAAAATGTCAAAGTTACTGGTAATGTCCTGGGTAAAGACTGGGTATCTGGATTTATAGAC
    AAAATTGACGGCAGTGGTAAATTAATTAATGTTGCATTTATCGGTAATGTTACATCTGTT
    GGTACTGGAGGCAACTTCTTAACAGGTATTGTGGGAGAAAACTGGAAAGGATACGTTGAA
    AGAGCATATGTTGATGCTCATATTAAAGGTAAGCGAGCTAAAGCTGCGGGTATAGCCTAC
    TGGTCACAAAACCAAGGGAATAACTTTACTATTGGATCTGAGGGGGCTATTAAAAAATCT
    GTTGTTAAAGGTACAATAGACGTTGAAAAACCAATTGAAGTTGGTGGCGCTGTTGGAAGT
    TTTACTTATCATGGTTCTATTGAAGATACTGTTTCTATGATGAAAGTTAAGAACGGTGAA
    ATTTTCTATGGTTCTAAAGATATTGATGATGATCCATATTACACAGGTAACCATGTTAAT
    CGAAACTACGTTGTTATAGGTGTTAGCGAAGGTACTTCTACATATAGATATTCTAATCAG
    CATAATCGTATTAAACCTATAACACAATCAGAAGCTGATGTTAAAATTGCAGAGACAGCT
    ATCACAGCAGATAAATTTACAATTACCGATCCAATTGTAAATAAACTTAACGACATTAAA
    CCAAAAGCTGACACTTATAAAAATACTCAAGATTACAAAGCTGAAAGAGAATTAGCGTAT
    CGTAATATTGAAAAACTTCAACCATTTTATAACAAAGACTGGATTGTAAATCAGGGTAAC
    AAGTTAGAGCAAGATTCAAATCTTGTGAAGAAAGAAGTTCTTTCTGTAATAGGTATGAAG
    AATGGTCAATTTGTTACAGATTTATCTGATATTGATAAGATTATGATTCACTACGCTGAT
    GGTACAAAGGAAGAAATGTCCGTGGCAGTTAATTCTGATTCTGGAGTAGCTCAAGTGAAA
    GAATATGATATAGTCGGTCAAAATATTGTTTATACACCAAACATGGTTGTTAAAGATCGT
    AGTGATTTGATGACTAAGGTTAGGGAAGCCTTGACTTCAGTGGAACTTGAGTCTGCGGGT
    GTCCGTTCGATCTTGGATAGACGTAATGACAGTAAAGATAAGAATGCAAACACAGAGCAA
    CGCCAAAATGGATATATTCGTGACTTCTATTTTGAGGAACATTTCCAAGAATTGAAGTCT
    AATATGGATACGATTGTCAAACATCTTGTGGAATCAGAAGATCATCAATTAAACATATCA
    GACGCAACTCAACGAGCTCTTGTTAAGAAAGTTCAAGACAATAGCGCAAAAATTATGTTA
    GGTCTTGCTTACCTAAATCGATATTATGGTATCAATTTTGATGGTAAAACCATTAAAGAC
    TTAATGATGTTTAAACCAGATTTTTATGGTAAAAATGTAGATGTCTTAGATAGACTGATT
    GAAATTGGTTCAAAAGAAAATACTTTAAAAGGTCATCGTACACATGATGCATTTAGAGAG
    GTATTGGCTAAGAACACGGTGTCTGGAAATCTTATTGACTTCTTACGATATAATATGAAG
    TTATTGACAGCCGACACAGATTTGAATGATTGGTTTATTCACTCCACTGAAGGTAAGGTT
    TATGTAGCAGAACGTCAGTCACGTGAAGAGGCTATTAAAACTGCTAAGTATCGTGCTTTT
    GACAATTTATCTCGCGGATACCATCAAAAGATGATTTTACCGCTCCTTAACCTCAAACAA
    ACCCAAGCATTCTTGATATCGACCTACAATACTATATCATTTGGGACTGCTAATAAATAC
    AATACCACACTGGATAAGTGGAAGGATAATATTAATTTGGCTGCAGACAGACAAATTAAC
    TATCTTGATTTCTGGTATCGTTTAGCAACAGATGCGGTAAAAAATAAGCTTGTCAAAGAT
    ATTGTAACTCCAGTATGGGAAGGTTACCAAGTTTGGGGTCATAAATGGGGGCAATGGATG
    GATAAATATGGTAAGTTTGAAGATGGAACAGGCATTTATCCACCTACTCGTGAGCTTTAC
    GGTCCTGTCGGTGAGCATTACGGTCCTAATGGAGCTGTTGCTGGGGCATATGCTACATAT
    TATGATGACAAGAATGATACTCGAGCTAAAGTTGTATTTGTTATGTCTGATATGATTAGT
    GAATATGGTGTGTCTGCATTTACGCATGAGACTACTCATATAAATGATCGCGTAGCTTAC
    TATGGAGGATACACGCATCGTGAAGGAACATTCTTGGAAGCCTTTGCTCAAGGAATGTTA
    CAGTCCCCAGCGGAACATGGACACCAAGGTGAATATGGTGCCCTTGGATTAAATATGGCA
    TTTGAACGTTCAAATGATGGTAATCAATGGTACAACTACAATCCTAATAAGCTTCAATCA
    CGAGAAGCTATTGATAAATATATGAAGAACTATAATGAAGCTCTTATGATGTTAGATTAT
    CTGGAAGCAGAATCTGTTTTACCTAAATTAAAAGGTAATAATGATAGATGGTTCAAGAAA
    ATGGATAAACAAATGCGTAAGGACGGACAACCTCACCAGTTTGACAAAATTCGCGATTTA
    AATAATGAAGAGAAGAAAATTCAATTAGCTTCTATTGAGGATTTAGTTGATAATAACTTT
    ATGACTAAACACGGTGCTCCTGGAAATGGTACATATAACCCATCAGATTTTAGTTCAGCA
    TATGTTAATATGAATATGATGACTGGTGTATACGGAGGTAACTCAAGTGATGGAGCTCCT
    GGCGCTGCTTCATTTAAACATAATACTTTCCGTATGTGGGGATACTTCGGATACGAAAAT
    GGATTCATCGGATATGCTTCTAATAAATATAAAGCCGAAGCCAATAAAGCAGGTCAAACT
    CTAAGTGATAAATATATCATCAATAAAGTTTCTGGTGGTACATTTAATACACTTGAAGCG
    TGGAAGAAAGAATGGTTTAAACAAATCAAAACTAAAGCTCAAAAAGGATTCACAGCAATT
    GAAATTGATGGTAAAACTATTGATTCATATGAAAAATTAAAAGACTTATTTGATAAAGCT
    GTTGAAGAAGATCTTAAAGGAACTGGAACGGATAAGACTGTGAAACTTAAAGAAAAAGTA
    TACAAACAACTCCTTAAAAACACAGACGGTTTCTCTGGTAATCTATTTACTGCACCACAA
    GCATAG
    60
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    3540
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    4140
    4200
    4260
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    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5460
    5520
    5580
    5640
    5700
    5706

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EL263_RS03280 [old locus tag: SPAT_0612 ]
  • symbol: EL263_RS03280
  • description: G5 domain-containing protein
  • length: 1901
  • theoretical pI: 5.1351
  • theoretical MW: 213004
  • GRAVY: -0.665913

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 703.8)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 313.9)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 67.6)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.9)
    E-set (CL0159) fn3; Fibronectin type III domain (PF00041; HMM-score: 14.1)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 10.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.98483
    • TAT(Tat/SPI): 0.008282
    • LIPO(Sec/SPII): 0.001095
    • Cleavage Site: CS pos: 33-34. VDA-AT. Pr: 0.9782
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_050245570 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSVESAPVEEVSGEVESKPEEKVAVKPESQPSDKQAEEPNVEPPVEQPKVPEQPVQPTQAEQPRIPKDSSQEDNPKEDRGAEETPKQEDTQPAEAPEIKVEEPVESKEETKTAKGTQEEDYVGEALVPEQLPEYKVTEGTLVEESTTELDYKTETTEDPTKYTDEETVLRNGEKGSQVTKTTYKTIGGVKTDQVLSTSTEVTKEPVNQQVIRGTKPIEGTTVETREEIISFETKEQEDDTLKRGTRQVTQEGVNDKKQITETYKTIRGEKTSDAPTITETVIEKPQDKIIKNGTKELEKPTLEWAKTDKDVLKKSATASYTLTKPAGVEIKSIKVALKDNTGTVVKEVTVEENNLQATLDKLKYYQGYTLSTTMVYDRGEGEETEKLEDKQIQLDLKKVEIKNIKETSLMNVDAEGNETDKSLLSEKPTDVSQLYLRVTTHDNKVTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRRADDTLSEEYVHYFEKQLPKVNNVYYNFNELVKDMQANPTGEFKLGADLNAANVKPNGKSYVTKPFKGKLLSNDGGRFTIHNIERPLFANIEGGKIHDINLANVNINMPWADKVAPIANVIKNNATIENVKVTGNVLGKDWVSGFIDKIDGSGKLINVAFIGNVTSVGTGGNFLTGIVGENWKGYVERAYVDAHIKGKRAKAAGIAYWSQNQGNNFTIGSEGAIKKSVVKGTIDVEKPIEVGGAVGSFTYHGSIEDTVSMMKVKNGEIFYGSKDIDDDPYYTGNHVNRNYVVIGVSEGTSTYRYSNQHNRIKPITQSEADVKIAETAITADKFTITDPIVNKLNDIKPKADTYKNTQDYKAERELAYRNIEKLQPFYNKDWIVNQGNKLEQDSNLVKKEVLSVIGMKNGQFVTDLSDIDKIMIHYADGTKEEMSVAVNSDSGVAQVKEYDIVGQNIVYTPNMVVKDRSDLMTKVREALTSVELESAGVRSILDRRNDSKDKNANTEQRQNGYIRDFYFEEHFQELKSNMDTIVKHLVESEDHQLNISDATQRALVKKVQDNSAKIMLGLAYLNRYYGINFDGKTIKDLMMFKPDFYGKNVDVLDRLIEIGSKENTLKGHRTHDAFREVLAKNTVSGNLIDFLRYNMKLLTADTDLNDWFIHSTEGKVYVAERQSREEAIKTAKYRAFDNLSRGYHQKMILPLLNLKQTQAFLISTYNTISFGTANKYNTTLDKWKDNINLAADRQINYLDFWYRLATDAVKNKLVKDIVTPVWEGYQVWGHKWGQWMDKYGKFEDGTGIYPPTRELYGPVGEHYGPNGAVAGAYATYYDDKNDTRAKVVFVMSDMISEYGVSAFTHETTHINDRVAYYGGYTHREGTFLEAFAQGMLQSPAEHGHQGEYGALGLNMAFERSNDGNQWYNYNPNKLQSREAIDKYMKNYNEALMMLDYLEAESVLPKLKGNNDRWFKKMDKQMRKDGQPHQFDKIRDLNNEEKKIQLASIEDLVDNNFMTKHGAPGNGTYNPSDFSSAYVNMNMMTGVYGGNSSDGAPGAASFKHNTFRMWGYFGYENGFIGYASNKYKAEANKAGQTLSDKYIINKVSGGTFNTLEAWKKEWFKQIKTKAQKGFTAIEIDGKTIDSYEKLKDLFDKAVEEDLKGTGTDKTVKLKEKVYKQLLKNTDGFSGNLFTAPQA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)C E Blue, G K Paterson, A R Kerr, M Bergé, J P Claverys, T J Mitchell
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract.
Infect Immun: 2003, 71(9);4925-35
[PubMed:12933834] [WorldCat.org] [DOI] (P p)

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