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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 12-FEB-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae ATCC 49619
- locus tag: EL263_RS03535 [old locus tag: SPAT_0659 ]
- pan locus tag?: PNEUPAN001646000
- symbol: EL263_RS03535
- pan gene symbol?: thiM-2
- synonym:
- product: hydroxyethylthiazole kinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: EL263_RS03535 [old locus tag: SPAT_0659 ]
- symbol: EL263_RS03535
- product: hydroxyethylthiazole kinase
- replicon: chromosome
- strand: +
- coordinates: 666357..667160
- length: 804
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NZ_AP018938 (666357..667160) NCBI
- BioCyc: EL263_RS03535 BioCyc
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0630 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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781ATGCAGGAATTTACAAATCCTTTTCCTATAGGCTCTAGTTCCCTCATTCACTGTATGACC
AATGAGATTTCTTGTGAGATGCTGGCAAATGGGATTTTGGCTCTGGGATGCAAACCTGTC
ATGGCAGATGATCCCCGTGAAGTTCTTGATTTTACTAAGCAAAGTCAGGCTCTCTTCATC
AATTTGGGGCATTTGTCAGCTGAGAAGGAAAAAGCAATCCGCATGGCAGCTTTGTATGCA
AACCAATCTTCTCTCCCGATGGTAGTAGATGCGGTTGGCGTAACGACTTCATCCATTCGT
AAGAGCTTAGTTAAAGACCTTTTAGACTATAGACCTACGGTCCTTAAAGGAAACATGTCA
GAAATTCGAAGTCTTGTTGGATTAAAGCACCACGGCGTTGGGGTCGATGCGAGTGCTAAA
GATCAAGAAACGGAGGATTTGCTTCAAGTCTTGAAAGACTGGTGTCAGACCTATCCTGGT
ATGTCTTTCTTAGTCACAGGTCCCAAGGACCTCGTCGTTTCGAAAAATCAGGTCGCTGTA
CTGGGAAATGGCTGTACTGAATTAGACTGGATAACAGGGACAGGAGACTTGGTTGGAGCC
TTAACAGCTGTTTTTCTCAGCCAAGGAAAGACTGGTTTTGAAGCTTCTTGCTTAGCAGTC
TCTTATCTCAATATCGCTGCTGAGAAAATAGTTGTTCAAGGAATGGGATTGGAAGAATTT
CGTTACCAAGTACTCAATCAGCTTTCGCTCCTAAGAAGAGATGAAAATTGGCTAGATACC
ATCAAAGGAGAGGTTTATGAATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: EL263_RS03535 [old locus tag: SPAT_0659 ]
- symbol: EL263_RS03535
- description: hydroxyethylthiazole kinase
- length: 267
- theoretical pI: 4.74606
- theoretical MW: 29135.4
- GRAVY: 0.0550562
⊟Function[edit | edit source]
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine hydroxyethylthiazole kinase (TIGR00694; EC 2.7.1.50; HMM-score: 164.2)and 2 moreUnknown function General YjeF family C-terminal domain (TIGR00196; HMM-score: 31.6)Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain I (TIGR02198; EC 2.7.1.-; HMM-score: 17.2)
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM: Ribokinase (CL0118) HK; Hydroxyethylthiazole kinase family (PF02110; HMM-score: 163.3)and 3 moreCarb_kinase; Carbohydrate kinase (PF01256; HMM-score: 28.3)Phos_pyr_kin; Phosphomethylpyrimidine kinase (PF08543; HMM-score: 20.3)Plasmid-antitox (CL0136) PHD_like; Antitoxin of toxin-antitoxin, RelE / RelB, TA system (PF12910; HMM-score: 12.6)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0.32
- Cytoplasmic Membrane Score: 9.55
- Cellwall Score: 0.12
- Extracellular Score: 0.01
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9894
- Cytoplasmic Membrane Score: 0.0021
- Cell wall & surface Score: 0.0005
- Extracellular Score: 0.0081
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.065471
- TAT(Tat/SPI): 0.008425
- LIPO(Sec/SPII): 0.029499
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: WP_001155189 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MQEFTNPFPIGSSSLIHCMTNEISCEMLANGILALGCKPVMADDPREVLDFTKQSQALFINLGHLSAEKEKAIRMAALYANQSSLPMVVDAVGVTTSSIRKSLVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPGMSFLVTGPKDLVVSKNQVAVLGNGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- data available for TIGR4
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0630 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]